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Desipramine | compare suppliers & send inquiries for free

Here you will find a list of producers, manufacturers and traders of Desipramine. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
France PCAS
Type: Producer
Produced in: France
France
India R. L. Fine Chem
Type: Producer
Produced in: India
India
Italy Lundbeck Pharma
Type: Producer
Produced in: Italy
Italy

Looking for Desipramine 50-47-5?

API | Excipient name:
Desipramine 
Synonyms:
Desipramin, Desipramina, Desipramine, Desipraminum, Desmethylimipramine, DMI, Monodemethylimipramine, Norimipramine  
Cas Number:
50-47-5 
DrugBank number:
DB01151 
Unique Ingredient Identifier:
TG537D343B

About Desipramine

It's time for some technical information for the ones who understand chemistry: Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation.

In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, Alpha-1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).

You can ask the supplier for more technical information about the product.

Desipramine manufacturers | traders | suppliers
We have 3 companies offering Desipramine from 3 different countries.

Get in contact with the supplier of your choice:

  • R. L. Fine Chem from India
  • PCAS from France
  • Lundbeck Pharma from Italy

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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