Dornase alfa | compare suppliers & send inquiries for free
Origin: United States
Speranza Chemical Co.,Ltd
MOQ: 1 kg
Origin: South Africa
Looking for Dornase alfa 143831-71-4?
About Dornase alfa
Why are professionals looking for Dornase alfa? Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products without affecting intracellular DNA.
In individuals with cystic fibrosis, extracellular DNA, which is an extremely viscous anion, is released by degenerating leukocytes that accumulate during inflammatory responses to infections. Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity.
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Dornase alfa manufacturers | traders | suppliers
We have 3 companies offering Dornase alfa from 3 different countries.
Get in contact with the supplier of your choice:
- Speranza Chemical Co.,Ltd from China
- Sigma-Aldrich from United States
- Bbi Enzymes from South Africa
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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