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Here you will find a list of producers, manufacturers and traders of Grazoprevir. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
Shandong Octagon Chemicals Limited

MOQ: 1 g
Type: Trader
Origin: China
China

Looking for Grazoprevir 1350514-68-9?

API | Excipient name:
Grazoprevir 
Synonyms:
 
Cas Number:
1350514-68-9 
DrugBank number:
DB11575 
Unique Ingredient Identifier:
8YE81R1X1J

About Grazoprevir

So, what does it do? Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients Treatment options for chronic Hepatitis C have advanced significantly since 20 with the development of Direct Acting Antivirals (DAAs) such as Grazoprevir. Grazoprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 Synthesis. These enzymes are essential for viral replication and serve to cleave the virally encoded polyprotein into mature proteins like NS3, NS4A, NS4B, NS5A and NS5B.

The barrier for develoment of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors, another class of DAAs Subtitutions at amino acid positions 155, 156, or 168 are known to confer resistance. The substitutions of the enzyme's catalytic triad consisting of H58, D82, and S139 are also likely to alter the affinity of the drug for NS3/4A or the activity of the enzyme itself. Despite this disadvantage Grazoprevir is still effective against HCV particularly when paired with Elbasvir.

You can ask the supplier for more technical information about the product.

Grazoprevir manufacturers | traders | suppliers
We have 1 companies offering Grazoprevir from 1 different countries.

Get in contact with the supplier of your choice:

  • Shandong Octagon Chemicals Limited from China

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