- Raw materials
- Alkalinizing agents
- Zinc carbonate
Zinc carbonate API Manufacturers & Suppliers
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Zinc carbonate | CAS No: 5263-02-5 | GMP-certified suppliers
A medication that serves as a zinc source for supplements and components in antacids and laxatives, primarily targeting zinc deficiency and digestive health maintenance.
Therapeutic categories
Product Snapshot
- Zinc carbonate is available in topical formulation types including suspension and ointment
- Its primary applications are for dermatological and wound care purposes
- The product is currently in experimental status and is not approved by the US FDA
Clinical Overview
Zinc carbonate exists as part of various compound classes, including alkalies, anions, electrolytes, and metal cations, and is structurally characterized by the incorporation of carbonate ions complexed with zinc. Experimental use of this compound primarily explores its properties as a potential source of zinc in supplements and as a component in antacids and laxatives, leveraging the essential biological roles of zinc as a trace element. However, definitive pharmacological activity or approved therapeutic applications remain to be established.
Key pharmacokinetic parameters such as absorption, distribution, metabolism, and excretion (ADME) are not well characterized for zinc carbonate in isolation. It is expected, by analogy with other zinc salts, that the compound dissociates to release zinc ions which participate in physiological processes including enzymatic functions, immune modulation, and cellular repair mechanisms.
Safety and toxicity considerations require careful evaluation since zinc ions in excess can cause gastrointestinal disturbances and systemic toxicity. No formal safety profile or dosage guidelines exist for zinc carbonate in pharmaceutical preparations at this time, necessitating cautious handling in experimental contexts.
Although currently classified in experimental groups with no approved marketed pharmaceutical formulations noted, zinc carbonate may be encountered in research and development settings. API procurement should prioritize suppliers with verified quality systems, ensuring compliance with relevant pharmacopeial standards where applicable. Analytical validation of identity, purity, and absence of contaminants is essential for reliable downstream formulation activities.
Identification & chemistry
| Generic name | Zinc carbonate |
|---|---|
| Molecule type | Small molecule |
| CAS | 5263-02-5 |
| UNII | EQR32Y7H0M |
| DrugBank ID | DB14494 |
Formulation & handling
- Zinc carbonate is a small molecule intended for topical administration, primarily formulated as suspensions or ointments.
- Its low LogP and high water solubility suggest minimal systemic absorption, focusing on localized skin effects.
- Formulations should account for stability in aqueous environments and avoid exposure to acidic conditions that may degrade the carbonate.
Regulatory status
| Lifecycle | The active pharmaceutical ingredient (API) has patent protection expiring in the United States in , with generic versions anticipated to enter the market thereafter, indicating a transition from exclusivity to increased market availability and competition. |
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| Markets | US |
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Supply Chain
| Supply chain summary | The supply landscape for zinc carbonate includes several originator companies producing branded products primarily in the US market. The presence of multiple brands indicates established market activity, although limited to US regions without significant EU or other global distribution noted. Patent expiry trends suggest that generic competition may already exist or is likely given the availability of multiple branded alternatives. |
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Zinc carbonate is a type of Alkalinizing agents
Alkalinizing agents, a pharmaceutical API category, refers to a group of substances used to increase the pH (alkalinity) of a solution or body fluid. These agents play a crucial role in various medical applications, such as the treatment of acidosis, kidney disorders, and certain drug overdoses.
One commonly used alkalinizing agent is sodium bicarbonate, which is highly effective in raising the pH of blood and urine. It works by neutralizing excess acid and restoring the acid-base balance in the body. Sodium bicarbonate is often administered intravenously in emergency situations to rapidly correct severe acidosis.
Another alkalinizing agent, acetazolamide, is frequently employed in the treatment of glaucoma and certain types of epilepsy. By inhibiting carbonic anhydrase, acetazolamide reduces the production of bicarbonate ions, leading to a systemic decrease in pH. This mechanism is particularly useful in lowering the intraocular pressure associated with glaucoma.
Alkalinizing agents are also utilized in the management of certain drug toxicities. For instance, methotrexate, a chemotherapy medication, can cause severe toxicity if its elimination is hindered. Alkalinizing the urine with agents like sodium bicarbonate enhances methotrexate solubility, preventing the formation of toxic crystals in the kidneys.
In conclusion, alkalinizing agents are indispensable pharmaceutical APIs that help correct acid-base imbalances, treat specific medical conditions, and mitigate drug toxicities. Their diverse applications make them valuable tools in modern medicine.
