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Alfaxalone | CAS No: 23930-19-0 | GMP-certified suppliers
A medication that provides general anesthesia for veterinary use, primarily in dogs and cats, facilitating safe and controlled CNS depression during clinical procedures.
Therapeutic categories
Product Snapshot
- Alfaxalone is an injectable veterinary anesthetic agent
- It is primarily utilized for anesthesia and sedation in animals
- The compound is approved for veterinary use but does not hold human regulatory approvals such as FDA or EMA
Clinical Overview
Chemically, alfaxalone belongs to the class of steroid compounds characterized by a hydroxylated prostane core, categorizing it among glucocorticoids, mineralocorticoids, and progestogen derivatives. This structural classification aligns with its pharmacological activity influencing central nervous system function.
Alfaxalone exerts its anesthetic effects as a central nervous system depressant, modulating neurotransmitter activity consistent with general anesthetics. While detailed pharmacodynamics and mechanism of action data for alfaxalone are not specified, as a neuroactive steroid, it is understood to act through modulation of gamma-aminobutyric acid (GABA) receptors, enhancing inhibitory neurotransmission which results in sedation and anesthesia.
Key ADME parameters remain unspecified in the available data; however, veterinary usage implies a pharmacokinetic profile suitable for inducing anesthesia with manageable onset and duration favorable to clinical procedures in companion animals.
Safety considerations include monitoring for CNS depression effects inherent to general anesthetics. Toxicological profiles in routine veterinary use support its safety when administered under veterinary supervision following approved dosing guidelines.
From an API procurement and quality perspective, sourcing of alfaxalone requires adherence to stringent purity standards and regulatory compliance pertinent to veterinary pharmaceuticals. Analytical verification of identity, potency, and impurity profiles ensures safe integration into finished formulations intended for animal anesthesia.
Identification & chemistry
| Generic name | Alfaxalone |
|---|---|
| Molecule type | Small molecule |
| CAS | 23930-19-0 |
| UNII | BD07M97B2A |
| DrugBank ID | DB11371 |
Formulation & handling
- Alfaxalone is a small molecule steroid with limited water solubility, requiring formulation strategies to enhance bioavailability for oral or injectable use.
- Due to its steroid structure, alfaxalone may require protection from light and oxidation during storage and handling.
- Its moderate lipophilicity (LogP 3.06) suggests compatibility with lipid-based formulations or micellar systems for improved delivery.
Regulatory status
Alfaxalone is a type of Anesthetics
Anesthetics are a crucial category of pharmaceutical Active Pharmaceutical Ingredients (APIs) widely used in the field of medicine. These substances play a vital role in inducing a temporary loss of sensation or consciousness, enabling medical procedures to be performed without pain or discomfort. Anesthetics can be classified into two primary types: general anesthetics and local anesthetics.
General anesthetics act on the central nervous system, producing a reversible loss of consciousness. They are administered through inhalation or injection routes and are commonly employed for major surgeries or procedures that require deep sedation. Examples of general anesthetics include sevoflurane, propofol, and isoflurane.
On the other hand, local anesthetics primarily target a specific region or part of the body, temporarily numbing the area and blocking pain signals. These APIs are frequently used in dental procedures, minor surgeries, and childbirth. Common local anesthetics include lidocaine, bupivacaine, and ropivacaine.
Anesthetics work by interfering with the transmission of nerve signals or by altering the activity of certain receptors in the nervous system. They offer precise control over pain management, allowing medical professionals to perform complex procedures with reduced patient discomfort and anxiety.
The development and manufacturing of anesthetics APIs require stringent quality control measures to ensure safety and efficacy. Pharmaceutical companies adhere to strict regulatory guidelines to produce high-quality APIs. The demand for anesthetics remains consistently high, making this category of APIs a critical component of the pharmaceutical industry.
In conclusion, anesthetics are indispensable pharmaceutical APIs used to induce temporary loss of sensation or consciousness. They can be classified into general and local anesthetics, each serving distinct purposes in medical procedures. The proper development and manufacturing of anesthetics APIs are essential to ensure safe and effective pain management in various healthcare settings.
Alfaxalone API manufacturers & distributors
Compare qualified Alfaxalone API suppliers worldwide. We currently have 1 companies offering Alfaxalone API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Changzhou Comwin Fine Che... | Producer | China | China | CoA | 235 products |
When sending a request, specify which Alfaxalone API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
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