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- Anti-infective Agents
- Asiaticoside
Asiaticoside API Manufacturers & Suppliers
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Asiaticoside | CAS No: 16830-15-2 | GMP-certified suppliers
A medication that supports tissue repair and exhibits potential anti-infective and anti-inflammatory effects for dermatological and wound healing applications.
Therapeutic categories
Product Snapshot
- Asiaticoside is available as topical formulations including ointment, liquid, and cream
- It is primarily used for skin-related therapeutic applications
- Asiaticoside is currently experimental and not approved for commercial use in the US market
Clinical Overview
Pharmacologically, asiaticoside is under experimental evaluation with limited detailed data on its exact mechanism of action. It is suggested to modulate inflammatory pathways and promote collagen synthesis, which may contribute to tissue repair processes. However, comprehensive pharmacodynamic profiles and validated clinical efficacy data remain unavailable.
Absorption, distribution, metabolism, and excretion (ADME) characteristics of asiaticoside are not fully elucidated. Preclinical studies indicate low oral bioavailability due to poor absorption and extensive metabolism, primarily involving hydrolysis to asiatic acid and other aglycones, followed by phase I and phase II biotransformation. The compound demonstrates moderate tissue distribution, but extensive pharmacokinetic characterization in humans is lacking.
Safety and toxicity profiles of asiaticoside are currently not well defined in controlled human studies. Experimental and in vitro data suggest a low toxicity potential, but rigorous safety assessments including genotoxicity, carcinogenicity, and long-term exposure effects are not yet established. This underscores the need for cautious evaluation in drug development contexts.
Asiaticoside is not marketed under any globally recognized pharmaceutical brand and remains an investigational compound. Its use is primarily confined to research settings and experimental formulations, particularly within dermatological and wound care domains.
When sourcing asiaticoside as an active pharmaceutical ingredient (API), quality considerations include ensuring botanical origin verification, absence of impurities and contaminants, and compliance with pharmacopeial standards where applicable. Reliable supply chain documentation supporting batch-to-batch consistency and traceability is essential to meet regulatory and formulation requirements.
Identification & chemistry
| Generic name | Asiaticoside |
|---|---|
| Molecule type | Small molecule |
| CAS | 16830-15-2 |
| UNII | PKO39VY215 |
| DrugBank ID | DB14081 |
Formulation & handling
- Asiaticoside is a small molecule API primarily formulated for topical applications such as ointments, creams, and liquids.
- Its moderate water solubility and low logP indicate a relatively balanced hydrophilic-lipophilic profile suitable for dermal absorption.
- Handling considerations include ensuring stability in topical formulations to prevent degradation and maintain efficacy during storage.
Regulatory status
| Lifecycle | The API is currently available in the US market, with primary patents having expired, allowing for generic manufacturing and increased market competition. Ongoing lifecycle management strategies may focus on formulation enhancements and regulatory updates. |
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| Markets | US |
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Supply Chain
| Supply chain summary | The manufacturing and supply landscape for Asiaticoside includes multiple originator companies providing branded products primarily in the US market, with notable brands such as Centella Scar Ylang Ylang and Dr.Different CICA Metal. These branded products indicate an established presence in the US, with potential extensions into other regions through diverse formulations. Patent status is not specified, but the presence of multiple branded versions suggests that either patents have expired or generic competition may be emerging. |
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Asiaticoside is a type of Anti-infective Agents
Anti-infective agents are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used in the treatment of various infectious diseases. These agents play a crucial role in combating bacterial, viral, fungal, and parasitic infections. The demand for effective anti-infective APIs has grown significantly due to the increasing prevalence of drug-resistant microorganisms.
Anti-infective APIs encompass a wide range of substances, including antibiotics, antivirals, antifungals, and antiparasitics. Antibiotics are particularly important in fighting bacterial infections and are further categorized into different classes based on their mode of action and target bacteria. Antivirals are designed to inhibit viral replication and are essential in the treatment of viral infections such as influenza and HIV. Antifungals combat fungal infections, while antiparasitics are used to eliminate parasites that cause diseases like malaria and helminthiasis.
The development and production of high-quality anti-infective APIs require stringent manufacturing processes and adherence to regulatory standards. Pharmaceutical companies invest heavily in research and development to discover new and more effective anti-infective agents. Additionally, ensuring the safety, efficacy, and stability of these APIs is of utmost importance.
The global market for anti-infective APIs is driven by factors such as the rising incidence of infectious diseases, the emergence of new and drug-resistant pathogens, and the growing demand for improved healthcare infrastructure. Continuous advancements in pharmaceutical technology and the development of innovative drug delivery systems further contribute to the expansion of this market.
In conclusion, anti-infective agents are a critical category of pharmaceutical APIs that play a pivotal role in treating infectious diseases. Their effectiveness in combating various types of infections makes them essential components in the arsenal of modern medicine.
