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Tacalcitol | CAS No: 57333-96-7 | GMP-certified suppliers
A medication that offers anti-inflammatory and antipsoriatic effects for topical management of psoriasis and related inflammatory skin conditions.
Therapeutic categories
Product Snapshot
- Tacalcitol is available as topical ointment and emulsion formulations
- It is primarily utilized for dermatological indications requiring topical vitamin D analogs
- The product is currently in experimental and investigational stages without approved regulatory status
Clinical Overview
Clinically, tacalcitol is classified as an investigational compound with potential applications in dermatology, particularly as an anti-inflammatory agent and antipsoriatic. Although specific approved indications are not established, its chemical and pharmacological profile suggests utility in the management of psoriasis and related inflammatory skin disorders. It is primarily formulated for topical use, given its action on epidermal cells.
Mechanistically, as a vitamin D analogue, tacalcitol is presumed to exert effects by modulating vitamin D receptors (VDRs) in keratinocytes. This interaction influences cell proliferation and differentiation pathways, which may contribute to the normalization of hyperproliferative epidermal tissue seen in psoriatic lesions. However, explicit mechanistic details and pharmacodynamics data remain unspecified.
ADME (absorption, distribution, metabolism, and excretion) parameters for tacalcitol have not been comprehensively characterized in public domain sources. Given its topical application, systemic exposure is expected to be limited, which may mitigate systemic toxicity concerns. Safety and toxicity profiles are not fully established, though typical considerations for vitamin D analogues include monitoring for hypercalcemia and related effects with systemic absorption.
Tacalcitol is recognized within multiple categories including anti-inflammatory agents, antipsoriatics for topical use, and dermatological preparations. It is a sterol derivative with roles in membrane lipid biology and fat-soluble vitamin function. Currently, tacalcitol remains under experimental and investigational status, with no widely recognized branded formulations marketed globally.
For API procurement, sourcing should prioritize manufacturers adhering to stringent quality controls and Good Manufacturing Practices (GMP), ensuring purity and stability of the secosteroid compound. Given its investigational status, regulatory compliance and detailed specification assessments are essential to support research or formulation development activities.
Identification & chemistry
| Generic name | Tacalcitol |
|---|---|
| Molecule type | Small molecule |
| CAS | 57333-96-7 |
| UNII | C2W72OJ5ZU |
| DrugBank ID | DB13689 |
Formulation & handling
- Tacalcitol is a small molecule vitamin D derivative formulated primarily for topical application.
- Low water solubility (1.05e-02 g/L) requires consideration of suitable solvents or emulsions for formulation.
- Stability and handling should account for potential light sensitivity typical of secosteroid compounds.
Regulatory status
Tacalcitol is a type of Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
Tacalcitol API manufacturers & distributors
Compare qualified Tacalcitol API suppliers worldwide. We currently have 2 companies offering Tacalcitol API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| ChemExpress | Producer | United States | China | CoA, ISO9001, MSDS, WC | 197 products |
| Heron (Shanghai) Pharmace... | Producer | China | China | CoA, GMP | 9 products |
When sending a request, specify which Tacalcitol API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Tacalcitol API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
