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Pradofloxacin | CAS No: 195532-12-8 | GMP-certified suppliers
A medication that treats bacterial infections in companion animals by providing broad-spectrum antibacterial activity against Gram-positive and Gram-negative pathogens.
Therapeutic categories
Product Snapshot
- Pradofloxacin is an oral fluoroquinolone antibiotic formulated as small molecule tablets for veterinary use
- It is primarily indicated for bacterial infections in animals, including skin, respiratory, and urinary tract infections
- Pradofloxacin has received approval for veterinary use but is not approved for human therapeutic markets such as FDA or EMA
Clinical Overview
Chemically, pradofloxacin belongs to the quinoline carboxylic acid class, characterized by a quinoline ring system substituted with one or more carboxyl groups. This structural class is notable for its antimicrobial properties. As a fluoroquinolone, pradofloxacin exerts its antibacterial effect through inhibition of bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for DNA replication, transcription, and repair. This mechanism confers broad-spectrum activity against a range of Gram-positive and Gram-negative pathogens commonly implicated in veterinary infections.
While specific pharmacodynamic data are not provided here, fluoroquinolones typically exhibit concentration-dependent bactericidal activity with significant post-antibiotic effects. Key absorption, distribution, metabolism, and excretion (ADME) characteristics vital for clinical use include favorable oral bioavailability and extensive tissue penetration, though exact parameters for pradofloxacin in target species need to be confirmed through empirical data.
Safety and toxicity considerations for pradofloxacin align with those known for fluoroquinolones, including potential cartilage toxicity in immature animals and the risk of selecting resistant bacterial strains if used improperly. Veterinary regulatory approval underscores its use under specified conditions to mitigate such risks.
Notable commercial products containing pradofloxacin are used exclusively in veterinary medicine within the European market. Due to its classification as a veterinary antimicrobial agent, adherence to stringent quality standards for active pharmaceutical ingredient (API) procurement is critical. This includes verification of purity, enantiomeric composition, and compliance with veterinary pharmacopoeial monographs to ensure consistent efficacy and safety in clinical applications.
Identification & chemistry
| Generic name | Pradofloxacin |
|---|---|
| Molecule type | Small molecule |
| CAS | 195532-12-8 |
| UNII | 6O0T5E048I |
| DrugBank ID | DB11453 |
Formulation & handling
- Pradofloxacin is a small molecule quinoline carboxylic acid with low water solubility, requiring formulation considerations for oral dosage forms. Its logP of -0.49 suggests moderate hydrophilicity, potentially influencing absorption and distribution. Approved for veterinary use, handling should consider stability in aqueous environments due to limited solubility.
Regulatory status
Pradofloxacin is a type of Antibacterials
Antibacterials, a category of pharmaceutical active pharmaceutical ingredients (APIs), play a crucial role in combating bacterial infections. These APIs are chemical compounds that target and inhibit the growth or kill bacteria, helping to eliminate harmful bacterial pathogens from the body.
Antibacterials are essential for the treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and more. They are commonly prescribed by healthcare professionals to combat both mild and severe bacterial infections.
Within the category of antibacterials, there are different classes and subclasses of APIs, each with distinct mechanisms of action and target bacteria. Some commonly used antibacterials include penicillins, cephalosporins, tetracyclines, macrolides, and fluoroquinolones. These APIs work by interfering with various aspects of bacterial cellular processes, such as cell wall synthesis, protein synthesis, DNA replication, or enzyme activity.
The development and production of antibacterial APIs require stringent quality control measures to ensure their safety, efficacy, and purity. Pharmaceutical manufacturers must adhere to Good Manufacturing Practices (GMP) and follow rigorous testing protocols to guarantee the quality and consistency of these APIs.
As bacterial resistance to antibiotics continues to be a significant concern, ongoing research and development efforts aim to discover and develop new antibacterial APIs. The evolution of antibacterials plays a crucial role in combating emerging bacterial strains and ensuring effective treatment options for infectious diseases.
In summary, antibacterials are a vital category of pharmaceutical APIs used to treat bacterial infections. They are designed to inhibit or kill bacteria, and their development requires strict adherence to quality control standards. By continually advancing research in this field, scientists and pharmaceutical companies can contribute to the ongoing battle against bacterial infections.
Pradofloxacin API manufacturers & distributors
Compare qualified Pradofloxacin API suppliers worldwide. We currently have 2 companies offering Pradofloxacin API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Changzhou Comwin Fine Che... | Producer | China | China | CoA | 235 products |
| Shandong Chenghui Shuangd... | Producer | China | China | CoA | 98 products |
When sending a request, specify which Pradofloxacin API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Pradofloxacin API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
