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- Sodium aurotiosulfate
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Sodium aurotiosulfate | CAS No: 33614-49-2 | GMP-certified suppliers
A medication that supports management of inflammatory and autoimmune musculoskeletal conditions through antiinflammatory and antirheumatic effects within gold-based therapeutic agents.
Therapeutic categories
Product Snapshot
- Sodium aurotiosulfate is supplied as a cutaneous administration kit
- It is primarily indicated for use in experimental applications
- The product is approved for use in the US market
Clinical Overview
The pharmacological profile and mechanism of action of sodium aurotiosulfate remain incompletely characterized in publicly accessible literature. However, gold-based compounds commonly demonstrate anti-inflammatory properties through modulation of immune response pathways, potentially influencing macrophage activity and cytokine production. The agent is believed to interact with sulfhydryl groups, contributing to its biological effects within connective tissue diseases.
Key absorption, distribution, metabolism, and elimination (ADME) parameters are not comprehensively described for sodium aurotiosulfate. As a gold complex, it may exhibit complex pharmacokinetics involving slow release of gold ions, tissue accumulation, and renal excretion. Close monitoring of plasma levels and organ function is typically advised in related gold therapies due to potential toxicity.
Safety considerations for gold-containing APIs include risks of nephrotoxicity, dermatologic reactions, and hematologic effects such as cytopenias. Long-term administration requires vigilance for cumulative toxicity and hypersensitivity. Regulatory approval statuses indicate sodium aurotiosulfate is both approved and experimental in various jurisdictions, reflecting ongoing evaluation of its benefit-risk profile.
Notable branded formulations and detailed clinical usage contexts are not specified. For formulation scientists and sourcing professionals, quality control of sodium aurotiosulfate APIs should prioritize rigorous purity assessment to limit metal contaminants and ensure batch consistency. Compliance with pharmacopeial standards and thorough characterization of physical and chemical properties is essential to support safe and effective final drug product manufacture.
Identification & chemistry
| Generic name | Sodium aurotiosulfate |
|---|---|
| Molecule type | Small molecule |
| CAS | 33614-49-2 |
| UNII | CKS1YQ9W1J |
| DrugBank ID | DB13743 |
Formulation & handling
- Sodium aurotiosulfate is a small molecule intended for cutaneous application, not suitable for oral or injectable routes.
- The molecule is water-soluble with a near-neutral LogP, indicating moderate skin penetration potential.
- Formulations should maintain stability in aqueous environments and avoid exposure to light and air to preserve activity.
Regulatory status
| Lifecycle | The active pharmaceutical ingredient is currently available in the US market with patent protection having expired, allowing for generic competition and indicating a mature market stage. Ongoing presence in the market is supported by established manufacturing and distribution channels. |
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| Markets | US |
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Supply Chain
| Supply chain summary | The manufacturing landscape for Sodium aurotiosulfate involves originator companies supplying branded products primarily in the US market, exemplified by offerings such as the T.R.U.E. Test Thin-Layer Rapid Use Patch Test. The presence of branded products appears concentrated in the US, with limited information on EU or other global markets. Patent expirations, if applicable, could lead to existing or anticipated generic competition, although specific patent status for this compound is not detailed. |
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Sodium aurotiosulfate is a type of Antidotes, Deterrents, and Toxicologic Agents
Antidotes, Deterrents, and Toxicologic Agents are an important category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that play a critical role in healthcare and toxicology. These substances are designed to counteract the effects of poisons, toxins, and overdoses, thereby saving lives and preventing severe health consequences.
Antidotes are substances that neutralize the toxic effects of certain drugs, chemicals, or poisons. They work by either directly binding to the toxic substance or by blocking its harmful actions on the body. Antidotes are administered in emergency situations to quickly reverse the effects of poisoning and restore normal physiological functions.
Deterrents, on the other hand, are pharmaceutical agents used to discourage or prevent harmful behaviors, such as substance abuse. They are designed to make the ingestion or misuse of certain substances unpleasant or less desirable. Deterrents can be formulated to cause unpleasant side effects, such as nausea or vomiting, when a particular substance is consumed in excessive amounts.
Toxicologic agents encompass a broad range of pharmaceutical APIs used in toxicology studies and research. These substances are employed to investigate the toxicity, metabolism, and mechanisms of action of various chemicals and compounds. Toxicologic agents are vital for understanding the potential hazards and risks associated with certain substances, ensuring the safety of drugs, and developing effective treatments for poisoning cases.
In conclusion, Antidotes, Deterrents, and Toxicologic Agents are essential categories of pharmaceutical APIs that address poisoning emergencies, deter harmful behaviors, and enable toxicological research. Their development and availability are crucial for safeguarding public health, enhancing patient care, and advancing our understanding of toxicology.
