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Prostaglandin D2
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Looking for Prostaglandin D2 API 41598-07-6?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Prostaglandin D2. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Prostaglandin D2
- Synonyms:
- (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate , (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate , 11-Dehydroprostaglandin F2-alpha , PGD2
- Cas Number:
- 41598-07-6
- DrugBank number:
- DB02056
- Unique Ingredient Identifier:
- RXY07S6CZ2
General Description:
Prostaglandin D2, identified by CAS number 41598-07-6, is a notable compound with significant therapeutic applications. The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
Classification:
Prostaglandin D2 belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid, classified under the direct parent group Prostaglandins and related compounds. This compound is a part of the Organic compounds, falling under the Lipids and lipid-like molecules superclass, and categorized within the Fatty Acyls class, specifically within the Eicosanoids subclass.
Categories:
Prostaglandin D2 is categorized under the following therapeutic classes: Autacoids, Biological Factors, Eicosanoids, Fatty Acids, Fatty Acids, Unsaturated, Inflammation Mediators, Lipids, Prostaglandin D2, antagonists & inhibitors, Prostaglandins, Prostaglandins D. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Prostaglandin D2 is a type of Antimetabolites
Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.
One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.
Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.
Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.
In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.
