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Arachidonic Acid | CAS No: 506-32-1 | GMP-certified suppliers
A medication that supports research into inflammatory and lipid-related conditions by providing a key fatty acid relevant to studies of cellular regulation and signaling pathways.
Therapeutic categories
Arachidonic AcidsCytochrome P-450 CYP2C9 SubstratesCytochrome P-450 SubstratesEicosanoidsFatty AcidsFatty Acids, Essential
Generic name
Arachidonic Acid
Molecule type
small molecule
CAS number
506-32-1
DrugBank ID
DB04557
Approval status
Experimental drug
Product Snapshot
- This product is an oral small‑molecule lipid available in capsule and liquid‑filled capsule formats
- It is primarily used in research settings related to inflammatory pathway modulation and lipid metabolism
- It is classified as experimental with no major market approvals
Clinical Overview
Arachidonic acid (CAS 506-32-1) is a long‑chain polyunsaturated fatty acid naturally present in animal tissues, particularly in phospholipid fractions of the liver, brain, and glandular organs. It is endogenously synthesized from dietary linoleic acid and serves as a key structural component of membrane phosphatides. Although not associated with an approved therapeutic indication, it remains relevant in research settings examining lipid signaling, inflammation, and cellular regulatory pathways.
Pharmacologically, arachidonic acid is the principal precursor for a wide range of eicosanoids, including prostaglandins, thromboxanes, and leukotrienes. These lipid mediators modulate vascular tone, platelet aggregation, immune cell function, and other homeostatic and inflammatory processes. The compound is metabolized through cyclooxygenase, lipoxygenase, and cytochrome P450 epoxygenase pathways, generating bioactive metabolites with diverse physiological effects.
The mechanism of action is not defined in a conventional drug context, but the compound’s biological activity arises from its controlled release from membrane phospholipids and subsequent enzymatic oxygenation. Its interactions with several cytochrome P450 isoforms, including CYP2C9, reflect its role as a substrate within endogenous oxidative metabolic systems.
Absorption, distribution, metabolism, and excretion parameters are primarily derived from nutritional and biochemical studies rather than clinical pharmacokinetics. Arachidonic acid is efficiently incorporated into cell membranes, undergoes rapid turnover during inflammatory responses, and is ultimately degraded via beta‑oxidation.
Safety considerations focus on its biochemical reactivity and potential to influence inflammatory pathways. Excessive or unregulated exposure in experimental systems may alter platelet activity, vascular responses, or immune signaling. No established therapeutic dose ranges exist due to its classification as an experimental compound.
From an API sourcing perspective, procurement should prioritize identity and purity verification, control of oxidative degradation, and appropriate stabilization against peroxidation. Specifications should address fatty acid profile consistency and limits on related lipid impurities to ensure suitability for research or formulation development contexts.
Pharmacologically, arachidonic acid is the principal precursor for a wide range of eicosanoids, including prostaglandins, thromboxanes, and leukotrienes. These lipid mediators modulate vascular tone, platelet aggregation, immune cell function, and other homeostatic and inflammatory processes. The compound is metabolized through cyclooxygenase, lipoxygenase, and cytochrome P450 epoxygenase pathways, generating bioactive metabolites with diverse physiological effects.
The mechanism of action is not defined in a conventional drug context, but the compound’s biological activity arises from its controlled release from membrane phospholipids and subsequent enzymatic oxygenation. Its interactions with several cytochrome P450 isoforms, including CYP2C9, reflect its role as a substrate within endogenous oxidative metabolic systems.
Absorption, distribution, metabolism, and excretion parameters are primarily derived from nutritional and biochemical studies rather than clinical pharmacokinetics. Arachidonic acid is efficiently incorporated into cell membranes, undergoes rapid turnover during inflammatory responses, and is ultimately degraded via beta‑oxidation.
Safety considerations focus on its biochemical reactivity and potential to influence inflammatory pathways. Excessive or unregulated exposure in experimental systems may alter platelet activity, vascular responses, or immune signaling. No established therapeutic dose ranges exist due to its classification as an experimental compound.
From an API sourcing perspective, procurement should prioritize identity and purity verification, control of oxidative degradation, and appropriate stabilization against peroxidation. Specifications should address fatty acid profile consistency and limits on related lipid impurities to ensure suitability for research or formulation development contexts.
Identification & chemistry
| Generic name | Arachidonic Acid |
|---|---|
| Molecule type | Small molecule |
| CAS | 506-32-1 |
| UNII | 27YG812J1I |
| DrugBank ID | DB04557 |
Pharmacology
Targets
| Target | Organism | Actions |
|---|---|---|
| Peroxisome proliferator-activated receptor alpha | Humans | |
| Bile acid receptor | Humans | ligand |
| Retinoic acid receptor RXR-alpha | Humans |
Formulation & handling
- Highly lipophilic long‑chain fatty acid requiring lipid‑based or liquid‑filled oral capsule formulations due to extremely low aqueous solubility.
- Prone to oxidative degradation; requires antioxidant protection and oxygen‑limited handling during manufacturing and storage.
- Oily, waxy solid at room temperature that may need controlled softening or dissolution in suitable excipients for uniform capsule filling.
Regulatory status
Arachidonic Acid API manufacturers & distributors
Compare qualified Arachidonic Acid API suppliers worldwide. We currently have 1 companies offering Arachidonic Acid API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| LGM Pharma | Distributor | United States | World | BSE/TSE, CEP, CoA, GMP, MSDS, USDMF | 441 products |
When sending a request, specify which Arachidonic Acid API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Arachidonic Acid API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
Frequently asked questions about Arachidonic Acid API
Sourcing
Which documents are typically required when sourcing Arachidonic Acid API?
Request the core API documentation set: USDMF (1 company), CEP (1 company), GMP (1 company), CoA (1 company), MSDS (1 company). Confirm versions and validity dates match the destination market to avoid delays in qualification.
Which manufacturers are known to produce Arachidonic Acid API?
Known or reported manufacturers for Arachidonic Acid: LGM Pharma. Evaluate their GMP history, scale, and regional coverage before requesting dossiers or allocating demand.
How can I request quotes for Arachidonic Acid API from GMP suppliers?
Submit quote requests through the supplier listings with your specs and required documents (specifications, target volume, delivery timeline, and destination). Providing consistent details upfront speeds comparable offers and clarifies technical feasibility.
Is a GMP audit report available for Arachidonic Acid manufacturers?
Audit reports may be requested for Arachidonic Acid: 0 GMP audit reports available. Confirm the scope and recency of any audit before relying on it for qualification decisions.
How many suppliers offer Arachidonic Acid API on Pharmaoffer?
Reported supplier count for Arachidonic Acid: 1 verified suppliers. Filter listings by certifications, regions, and delivery options to match your qualification plan.
Which countries are known to manufacture Arachidonic Acid API?
Production countries reported for Arachidonic Acid: . Knowing the manufacturing geography helps anticipate logistics lead times and import compliance needs.
Which certifications do suppliers of Arachidonic Acid usually hold?
Common certifications for Arachidonic Acid suppliers: USDMF (1 company), CEP (1 company), GMP (1 company), CoA (1 company), MSDS (1 company). Always verify issuing authorities and expiry dates when reviewing audit packages.
Technical
What is Arachidonic Acid (CAS 506-32-1) used for?
Arachidonic Acid is used in research settings to study lipid signaling, inflammatory pathways, and the enzymatic formation of eicosanoids such as prostaglandins, thromboxanes, and leukotrienes. It also supports investigations into membrane phospholipid dynamics and cellular regulatory processes involving COX, LOX, and CYP450 pathways. It has no approved therapeutic use and is applied only for experimental or development purposes.
Which therapeutic class does Arachidonic Acid fall into?
Arachidonic Acid belongs to the following therapeutic categories: Arachidonic Acids, Cytochrome P-450 CYP2C9 Substrates, Cytochrome P-450 Substrates, Eicosanoids, Fatty Acids. This positioning helps teams compare alternative APIs, anticipate pharmacology expectations, and align early research priorities.
What should someone know about the safety or toxicity profile of Arachidonic Acid?
Arachidonic Acid participates in inflammatory and vascular signaling, so excessive or unregulated exposure in experimental settings may modify platelet function, vascular tone, or immune responses. Its polyunsaturated structure makes it susceptible to oxidative degradation, and peroxidation products may contribute to biochemical reactivity. No therapeutic safety thresholds are defined, but maintaining controlled concentrations and preventing oxidation are important for research use.
What are important formulation and handling considerations for Arachidonic Acid as an API?
Arachidonic Acid’s extremely low aqueous solubility requires lipid‑based or liquid‑filled capsule formulations to ensure uniform dosing. Its high susceptibility to oxidative degradation necessitates inclusion of antioxidants and processing under oxygen‑limited conditions. The oily, waxy consistency at room temperature may require controlled softening or dissolution in compatible excipients to achieve consistent capsule filling and stability.
Is Arachidonic Acid a small molecule?
Arachidonic Acid is classified as a small molecule. That classification shapes process design, impurity profiling, and analytical control strategies.
Are there special stability concerns for oral Arachidonic Acid?
Oral Arachidonic Acid is prone to oxidative degradation, so it requires antioxidant protection and oxygen‑limited handling during manufacturing and storage. Its highly lipophilic, oily–waxy nature also necessitates lipid‑based or liquid‑filled capsule systems to maintain physical stability. Controlled softening or dissolution in suitable excipients is needed to ensure uniform capsule filling and minimize variability.
Pharmaoffer
How does Pharmaoffer’s Smart Sourcing Service help with Arachidonic Acid procurement?
Pharmaoffer's Smart Sourcing Service coordinates compliant suppliers, documentation, and competitive quotes for Arachidonic Acid. It centralizes outreach, follow-ups, and document validation to shorten procurement timelines.
Is Arachidonic Acid included in the PRO Data Insights coverage?
PRO Data Insights coverage for Arachidonic Acid: 228 verified transactions across 59 suppliers and 61 buyers worldwide. Use the dataset to benchmark suppliers and monitor regulatory activity where available.
Where can I access the API market report for Arachidonic Acid?
Market report availability for Arachidonic Acid: Report Available. The report highlights demand trends, pricing drivers, and supplier landscape insights for procurement planning.
