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Thymol | CAS No: 89-83-8 | GMP-certified suppliers
A medication that provides antiseptic, antibacterial, and antifungal benefits for local use, supporting infection control and product stability in pharmaceutical formulations.
Therapeutic categories
Product Snapshot
- Thymol is available in multiple formulation types including oils, liquids, sprays, gels, patches, and soaps for oral, buccal, topical, transdermal, dental, nasal, and respiratory routes
- Its primary therapeutic uses include antiseptic, antimicrobial, and oral care applications
- Thymol products are approved for use in key regulatory markets such as the US and Canada
Clinical Overview
Clinically, thymol has historically been utilized for its antiseptic, antibacterial, and antifungal properties. It was also previously applied as a vermifuge. While it is approved for use, specific contemporary clinical indications and detailed pharmacodynamic profiles are not well-established or explicitly defined in current pharmacopeial sources.
The mechanism of action of thymol, though not fully elucidated in clinical terms, is generally attributed to disruption of microbial cell membranes leading to compromised integrity and function, which underpins its antimicrobial effects. The compound's antiseptic action supports its use as a stabilizer and preservative component in certain pharmaceutical formulations, contributing to product integrity by inhibiting microbial contamination.
Absorption, distribution, metabolism, and excretion (ADME) parameters for thymol have not been comprehensively characterized according to publicly available data. Its lipophilic monoterpenoid structure suggests potential for rapid absorption and tissue distribution, though systemic exposure and metabolic pathways remain to be further detailed.
Safety and toxicity data indicate thymol should be used with caution; phenolic compounds may cause irritation and sensitization upon prolonged exposure or at higher concentrations. Toxicological profiling supports controlled usage levels to minimize risk of adverse effects, particularly in topical or oral pharmaceutical applications.
Thymol is present in various antifungal and antiseptic formulations globally, recognized within anti-infective agent categories, including local use antifungal agents. It is registered under multiple regulatory jurisdictions, supporting its inclusion in pharmaceutical manufacturing as an active or stabilizing component.
From a sourcing perspective, pharmaceutical-grade thymol must comply with stringent purity and quality standards to ensure batch-to-batch consistency and safety. Consideration of origin, extraction methods, and supplier certification is critical to meet regulatory and formulation requirements for advanced pharmaceutical production.
Identification & chemistry
| Generic name | Thymol |
|---|---|
| Molecule type | Small molecule |
| CAS | 89-83-8 |
| UNII | 3J50XA376E |
| DrugBank ID | DB02513 |
Formulation & handling
- Thymol is a small molecule aromatic monoterpenoid primarily formulated for topical, oral, and transdermal delivery.
- It exhibits limited water solubility (0.643 g/L) and moderate lipophilicity (logP 3.43), influencing formulation strategies for solvent and vehicle selection.
- Handling considerations include its solid state at room temperature and use in various forms such as oils, sprays, and mouthwashes without noted peptide or biologic instability concerns.
Regulatory status
| Lifecycle | The API's primary patent protection in the US and Canada expired recently, leading to the introduction of generic equivalents and increased market competition. As a result, the product is transitioning into the mature phase of its lifecycle in these regions. |
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| Markets | US, Canada |
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Supply Chain
| Supply chain summary | The manufacturing and supply landscape for Thymol includes several originator companies producing branded products primarily in the US and Canadian markets. The presence of multiple branded formulations indicates established market penetration in North America, with no current data on EU or other regions. Patent expiry status is not provided, so the extent of existing or upcoming generic competition cannot be determined from the available information. |
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Thymol is a type of Aromatase inhibitors
Aromatase inhibitors (AIs) are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) commonly used in the treatment of hormone-sensitive conditions, including breast cancer and endometriosis. These compounds work by blocking the enzyme aromatase, which is responsible for the conversion of androgens into estrogens in peripheral tissues.
AIs are classified into two main types: steroidal and non-steroidal inhibitors. Steroidal AIs, such as exemestane, bind irreversibly to aromatase, while non-steroidal AIs, such as anastrozole and letrozole, inhibit aromatase activity reversibly. Both types effectively reduce estrogen levels, which is beneficial in hormone-driven cancers where estrogen promotes tumor growth.
The use of AIs in breast cancer treatment has significantly improved patient outcomes, particularly in postmenopausal women. By suppressing estrogen production, AIs prevent estrogen from fueling the growth of estrogen receptor-positive breast cancer cells. They are often prescribed as adjuvant therapy after surgery or as a first-line treatment for metastatic breast cancer.
Apart from their application in breast cancer, AIs have also shown efficacy in managing endometriosis, a painful condition where endometrial tissue grows outside the uterus. By reducing estrogen levels, AIs help alleviate symptoms and inhibit the growth of endometrial lesions.
Overall, aromatase inhibitors are vital components of modern pharmaceutical therapies targeting hormone-related diseases. Their ability to modulate estrogen levels through enzymatic inhibition has revolutionized the treatment landscape for breast cancer and endometriosis, improving patient prognosis and quality of life.
Thymol (Aromatase inhibitors), classified under Hormonal Agents
Hormonal agents are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) widely used in the medical field. These substances play a crucial role in regulating and modulating hormonal functions within the body. Hormonal agents are designed to mimic or manipulate the effects of naturally occurring hormones, allowing healthcare professionals to treat various endocrine disorders and hormonal imbalances.
Hormonal agents are commonly employed in the treatment of conditions such as hypothyroidism, hyperthyroidism, diabetes, and hormonal cancers. These APIs work by interacting with specific hormone receptors, either by stimulating or inhibiting their activity, to restore the balance of hormones in the body. They can be administered orally, intravenously, or through other routes depending on the specific medication and patient needs.
Pharmaceutical companies employ rigorous manufacturing processes and quality control measures to ensure the purity, potency, and safety of hormonal agent APIs. These APIs are synthesized using chemical or biotechnological methods, often starting from natural hormone sources or through recombinant DNA technology. Stringent regulatory guidelines are in place to guarantee the efficacy and safety of hormonal agent APIs, ensuring that patients receive high-quality medications.
As the demand for hormone-related therapies continues to grow, ongoing research and development efforts focus on enhancing the effectiveness and reducing the side effects of hormonal agent APIs. This includes the exploration of novel delivery systems, advanced formulations, and targeted drug delivery methods. By continuously advancing our understanding and capabilities in hormonal agents, the medical community can improve patient outcomes and quality of life for individuals with hormonal disorders.
Thymol API manufacturers & distributors
Compare qualified Thymol API suppliers worldwide. We currently have 3 companies offering Thymol API, with manufacturing taking place in 2 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Caesar & Loretz GmbH (CAE... | Distributor | Germany | Unknown | BSE/TSE, CoA, GMP, ISO9001, MSDS | 211 products |
| Frey & Lau GmbH | Producer | Germany | Unknown | CoA | 5 products |
| Pharm Rx Chemical Corp | Distributor | United States | India | BSE/TSE, CoA, GMP, MSDS, USDMF | 166 products |
When sending a request, specify which Thymol API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Thymol API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
