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Sodium arsenite | CAS No: 7784-46-5 | GMP-certified suppliers
A medication that serves as an investigational arsenical reagent used primarily in experimental research on enzyme inhibition, oxidative stress, and cellular protein interactions in molecular biology.
Therapeutic categories
Product Snapshot
- Sodium arsenite is an inorganic compound primarily considered for injectable formulation
- It is mainly investigated for oncology applications as an antineoplastic agent
- The compound currently holds investigational status and lacks full approval from regulatory authorities such as the FDA or EMA
Clinical Overview
The compound’s mechanism of action is not fully characterized in clinical contexts. However, as an arsenical and sulfhydryl reagent, sodium arsenite is known to interact with cellular proteins by binding to thiol groups, potentially modulating enzymatic activity. This property underpins its use in research settings to study oxidative stress, apoptosis pathways, and enzyme inhibition.
Absorption, distribution, metabolism, and excretion (ADME) parameters of sodium arsenite have been investigated in preclinical models. When administered, arsenite ions are absorbed and widely distributed in the body, with a particular affinity for thiol-containing biomolecules. Metabolism involves biotransformation into methylated arsenic species, which may influence toxicity profiles. Renal excretion is a primary elimination route. The compound’s pharmacokinetic profile contributes to its biological activity and toxicity.
Safety and toxicity considerations are critical due to the inherent toxic potential of arsenic compounds. Sodium arsenite exhibits cytotoxicity and genotoxicity at certain concentrations, with risks including oxidative damage and interference with cellular respiration. Its use is restricted to controlled experimental environments, and exposure guidelines must strictly adhere to regulatory standards to minimize occupational and environmental hazards.
Sodium arsenite is investigational and not marketed under any pharmaceutical brand names. It is predominantly utilized in research laboratories focusing on molecular and cellular biology.
For sourcing and quality assurance, procurement of sodium arsenite API requires stringent compliance with purity specifications and regulatory standards pertinent to arsenical substances. Suppliers should provide certificates of analysis detailing heavy metal content, purity levels, and absence of contaminating species. Due to its toxic profile, handling and storage protocols must conform to safety regulations to ensure user protection and product integrity.
Identification & chemistry
| Generic name | Sodium arsenite |
|---|---|
| Molecule type | Small molecule |
| CAS | 7784-46-5 |
| UNII | 48OVY2OC72 |
| DrugBank ID | DB18508 |
Formulation & handling
- Sodium arsenite is a small molecule suitable for injectable formulations due to its hydrophilic nature and low LogP.
- Its stability profile requires careful handling under controlled conditions to prevent degradation and ensure safety.
- The compound does not exhibit peptide or biologic characteristics, indicating standard storage and handling protocols apply.
Regulatory status
Sodium arsenite is a type of Electrolytes
Electrolytes are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) that play a vital role in maintaining the balance of essential ions in the body. These ions include sodium, potassium, calcium, magnesium, and chloride, among others. Electrolytes are responsible for maintaining proper hydration, regulating nerve and muscle function, and supporting various physiological processes.
In the pharmaceutical industry, electrolytes are widely utilized in the formulation of oral rehydration solutions, intravenous fluids, and dialysis solutions. These medications are employed to treat conditions such as dehydration, electrolyte imbalances, and renal dysfunction.
The availability of high-quality electrolyte APIs is of utmost importance to ensure the efficacy and safety of these pharmaceutical products. Pharmaceutical manufacturers rely on reputable suppliers who adhere to stringent quality control measures and comply with Good Manufacturing Practices (GMP) to produce electrolyte APIs of consistent quality.
To meet regulatory requirements, electrolyte APIs undergo rigorous testing to confirm their identity, purity, and potency. This includes analysis using advanced techniques such as high-performance liquid chromatography (HPLC), mass spectrometry (MS), and atomic absorption spectroscopy (AAS).
In conclusion, electrolytes are a vital category of pharmaceutical APIs used to maintain the balance of essential ions in the body. They are extensively employed in various medications aimed at treating dehydration, electrolyte imbalances, and renal dysfunction. Pharmaceutical manufacturers prioritize the use of high-quality electrolyte APIs to ensure the safety and efficacy of their products, and adherence to stringent regulatory standards is crucial in their production and testing processes.
Sodium arsenite API manufacturers & distributors
Compare qualified Sodium arsenite API suppliers worldwide. We currently have 1 companies offering Sodium arsenite API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| ChemCon GmbH | Producer | Germany | Germany | CoA, GMP, MSDS | 36 products |
When sending a request, specify which Sodium arsenite API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Sodium arsenite API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
