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Erythritol | CAS No: 149-32-6 | GMP-certified suppliers
A medication that serves as a sugar alcohol investigated for coronary vasodilation, potentially improving cardiovascular circulation with low toxicity and high purity requirements for pharmaceutical use.
Therapeutic categories
AlcoholsCarbohydratesCardiovascular AgentsSugar AlcoholsVasodilating Agents
Generic name
Erythritol
Molecule type
small molecule
CAS number
149-32-6
DrugBank ID
DB04481
Approval status
Experimental drug
Product Snapshot
- Erythritol is an oral small molecule formulation primarily used as a sugar substitute in food and pharmaceutical products
- Its main applications focus on diabetic and weight management support due to its low-calorie properties
- Currently, erythritol has experimental status with no formal approvals from major regulatory agencies such as the FDA or EMA
Clinical Overview
Erythritol (CAS Number 149-32-6) is a four-carbon sugar alcohol naturally occurring in various organisms including algae, fungi, and lichens. Structurally, it belongs to the class of sugar alcohols—hydrogenated carbohydrates characterized by the reduction of carbonyl groups to hydroxyl groups. It is chemically related to other polyols used in both food and pharmaceutical applications.
Although erythritol’s clinical indications are not formally defined, it has been investigated as a coronary vasodilator. This potential cardiovascular effect suggests utility in modulating blood vessel tone to improve coronary circulation. Its sweetness is approximately twice that of sucrose, which also underpins its use as a non-caloric sweetener in nutritional formulations.
Pharmacological data specific to erythritol’s mechanism of action in vasodilation are limited and remain experimental. The available evidence does not establish definitive pharmacodynamics or pharmacokinetic parameters essential for therapeutic application. As such, erythritol is not currently approved for any formal medicinal use.
Regarding absorption, distribution, metabolism, and excretion (ADME), erythritol exhibits high gastrointestinal absorption but is largely excreted unchanged in urine, indicating minimal metabolism. This profile is generally associated with low systemic toxicity and limited metabolic interaction.
Safety considerations primarily relate to its sugar alcohol class, which can cause gastrointestinal discomfort at high doses due to osmotic effects. No significant toxicity has been reported at typical exposure levels in food or investigational settings. Because erythritol is classified as experimental, rigorous clinical data supporting safety and efficacy for vasodilation are lacking.
In the context of pharmaceutical API sourcing, erythritol requires pharmaceutical-grade quality with stringent control of purity and residual solvents to ensure suitability for cardiovascular research or formulation. Suppliers should provide comprehensive certificates of analysis and comply with relevant pharmacopeial standards to guarantee batch-to-batch consistency.
Although erythritol’s clinical indications are not formally defined, it has been investigated as a coronary vasodilator. This potential cardiovascular effect suggests utility in modulating blood vessel tone to improve coronary circulation. Its sweetness is approximately twice that of sucrose, which also underpins its use as a non-caloric sweetener in nutritional formulations.
Pharmacological data specific to erythritol’s mechanism of action in vasodilation are limited and remain experimental. The available evidence does not establish definitive pharmacodynamics or pharmacokinetic parameters essential for therapeutic application. As such, erythritol is not currently approved for any formal medicinal use.
Regarding absorption, distribution, metabolism, and excretion (ADME), erythritol exhibits high gastrointestinal absorption but is largely excreted unchanged in urine, indicating minimal metabolism. This profile is generally associated with low systemic toxicity and limited metabolic interaction.
Safety considerations primarily relate to its sugar alcohol class, which can cause gastrointestinal discomfort at high doses due to osmotic effects. No significant toxicity has been reported at typical exposure levels in food or investigational settings. Because erythritol is classified as experimental, rigorous clinical data supporting safety and efficacy for vasodilation are lacking.
In the context of pharmaceutical API sourcing, erythritol requires pharmaceutical-grade quality with stringent control of purity and residual solvents to ensure suitability for cardiovascular research or formulation. Suppliers should provide comprehensive certificates of analysis and comply with relevant pharmacopeial standards to guarantee batch-to-batch consistency.
Identification & chemistry
| Generic name | Erythritol |
|---|---|
| Molecule type | Small molecule |
| CAS | 149-32-6 |
| UNII | RA96B954X6 |
| DrugBank ID | DB04481 |
Pharmacology
Targets
| Target | Organism | Actions |
|---|---|---|
| 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) |
Formulation & handling
- Erythritol is a small molecule sugar alcohol intended primarily for oral formulations due to its high water solubility and low logP.
- As a chemically stable solid with high aqueous solubility, erythritol requires standard handling without special moisture protection.
- Its classification as a sugar alcohol suggests minimal sensitivity to food or enzymatic degradation, supporting flexible administration conditions.
Regulatory status
Erythritol API manufacturers & distributors
Compare qualified Erythritol API suppliers worldwide. We currently have 1 companies offering Erythritol API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Changzhou Comwin Fine Che... | Producer | China | China | BSE/TSE, CoA, ISO9001, MSDS | 235 products |
When sending a request, specify which Erythritol API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Erythritol API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
