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Date | Seller | Exporter country | Buyer | Importer country | Product | Quantity (KG) | Price per KG | Latest transactions |
---|---|---|---|---|---|---|---|---|
25-Sep-2024 | (Hidden) | India | ALLPHAMED ... | Germany | MIGLUSTAT | 12.40 | $ @36$-7! | Check all data |
25-Sep-2024 | (Hidden) | India | ALLPHAMED ... | Germany | MIGLUSTAT | 0.77 | $ @36$-7! | |
25-Sep-2024 | (Hidden) | India | ALLPHAMED ... | Germany | MIGLUSTAT | 3.20 | $ @36$-7! |
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Looking for Miglustat API 72599-27-0?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Miglustat. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Miglustat
- Synonyms:
- BuDNJ , Butyldeoxynojirimycin , Miglustatum , N-Butylmoranoline , NB-dnj , Zavesca
- Cas Number:
- 72599-27-0
- DrugBank number:
- DB00419
- Unique Ingredient Identifier:
- ADN3S497AZ
About Miglustat
More information about the use of: Miglustat. Miglustat, commonly marketed under the trade name Zavesca, is a drug used to treat Gaucher disease. It inhibits the enzyme glucosylceramide synthase, an essential enzyme for the synthesis of most glycosphingolipids. It is only used for patients who cannot be treated with enzyme replacement therapy with imiglucerase.
Miglustat is now the first and only approved therapy for patients with Niemann-Pick disease type C (NP-C). It has recently been approved for treatment of progressive neurological symptoms in adult and pediatric patients in the European Union, Brazil, and South Korea. Miglustat was first developed as an anti-HIV agent in the 1990s. However, clinical experience with miglustat showed that therapeutic levels of the drug could not be achieved in patients without a high incidence of adverse effect.
Check who is selling Miglustat in the overview above.
Miglustat is a type of Glycosides
Glycosides are a prominent subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in the development of various drugs and medicines. These compounds are characterized by the presence of a glycosidic bond, which connects a sugar molecule (glycone) to a non-sugar component (aglycone). Glycosides have gained significant attention in the pharmaceutical industry due to their diverse biological activities and therapeutic potential. They are widely used as natural sources for drug discovery and development. Many plants produce glycosides, and these natural compounds exhibit a wide range of pharmacological effects, such as anti-inflammatory, anticancer, antimicrobial, and antioxidant properties.
The extraction and isolation of glycosides from natural sources require specialized techniques like chromatography, solvent extraction, and purification methods. Once isolated, glycosides undergo rigorous testing and evaluation to determine their safety, efficacy, and dosage requirements.
Pharmaceutical companies utilize glycosides in the formulation of various medications, including cardiovascular drugs, anticancer agents, and anti-diabetic medications. Glycosides also serve as precursors for the synthesis of other pharmaceutical compounds, contributing to the development of new drugs and therapies.
As research in the field of glycosides continues to advance, scientists are exploring their potential applications in drug delivery systems, bioavailability enhancement, and targeted drug delivery. These innovative approaches aim to optimize the therapeutic benefits of glycosides and improve patient outcomes.
In conclusion, glycosides are a vital subcategory of pharmaceutical APIs, offering immense potential for drug development and therapeutic applications. Continued research and exploration of glycosides are crucial for expanding our understanding of their properties and unlocking their full pharmaceutical potential.
Miglustat (Glycosides), classified under Cardiac stimulants
Cardiac stimulants are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used in the treatment of cardiac disorders. These medications are designed to enhance the functioning of the heart by stimulating its electrical impulses and increasing its contractility.
Cardiac stimulants work by targeting specific receptors in the heart, promoting the release of neurotransmitters such as norepinephrine and epinephrine. These neurotransmitters bind to adrenergic receptors, leading to an increased heart rate and force of contraction, which helps improve cardiac output.
One commonly used cardiac stimulant API is Dobutamine. Dobutamine acts primarily on beta-1 adrenergic receptors in the heart, increasing the strength of cardiac contractions while minimizing the impact on heart rate. This makes it a valuable medication in cases of acute heart failure or during cardiac stress testing.
Another well-known cardiac stimulant API is Isoproterenol. Isoproterenol acts on both beta-1 and beta-2 adrenergic receptors, resulting in increased heart rate, contractility, and relaxation of the smooth muscles in the bronchi. It is commonly used in the treatment of bradycardia, heart block, and certain types of asthma.
Cardiac stimulant APIs play a vital role in cardiovascular medicine and are often used in emergency situations or as temporary measures to improve heart function. However, it is important to note that their use requires careful monitoring and should be administered under medical supervision due to potential side effects such as increased blood pressure, arrhythmias, and myocardial ischemia.
In conclusion, cardiac stimulant APIs are a critical category of pharmaceutical ingredients used to enhance heart function. Medications like Dobutamine and Isoproterenol act on specific receptors in the heart, leading to increased contractility and heart rate. While these medications provide important therapeutic benefits, their use should be closely monitored by medical professionals due to potential side effects.
Miglustat manufacturers | traders | suppliers
We have 2 companies offering Miglustat produced in 2 different countries.
Get in contact with the supplier of your choice:
- TIEFENBACHER API + Ingredients from Germany, product country of origin Unknown
- Amino Chemicals from Malta, product country of origin Malta
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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