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Quercetin | CAS No: 117-39-5 | GMP-certified suppliers
A medication that is widely researched for its antioxidant and protective roles in managing oxidative stress across diverse experimental and preclinical health contexts.
Therapeutic categories
Product Snapshot
- Oral small-molecule flavonoid typically supplied in tablet form
- Investigated for antioxidant and anti-inflammatory applications across various research areas
- Classified as experimental with no FDA or EMA approvals
Clinical Overview
Pharmacologically, quercetin functions as an antioxidant capable of interacting with reactive oxygen species and metal ions. It also inhibits multiple metabolizing enzymes and transporters, including several cytochrome P450 isoforms, catechol‑O‑methyltransferase, P‑glycoprotein, BCRP/ABCG2, OATP1B1, and OATP2B1. These interactions can affect experimental drug disposition models and are relevant when evaluating potential pharmacokinetic interactions in preclinical studies.
The mechanism of action most clearly defined for quercetin is inhibition of quinone reductase 2. This enzyme participates in the metabolic handling of quinolines in humans and in Plasmodium species. Inhibition in parasitic systems may promote oxidative stress, a proposed pathway for antiplasmodial activity in vitro. These mechanistic observations remain investigational and are not linked to an approved therapeutic use.
Absorption, distribution, metabolism, and excretion characteristics vary due to glycosylation state, intestinal metabolism, and extensive phase II conjugation. Oral bioavailability is generally limited and influenced by transporter interactions. Metabolites include glucuronide, sulfate, and methylated conjugates, which dominate systemic exposure.
Safety assessments indicate that quercetin exhibits dose‑dependent gastrointestinal effects and potential interactions with xenobiotic‑metabolizing enzymes. High concentrations in vitro have been associated with pro‑oxidant behavior, highlighting the importance of controlled experimental conditions. No established clinical safety profile exists for approved therapeutic use.
For API procurement, sourcing should prioritize authenticated botanical or synthetic origins, control of flavonoid profile, and compliance with impurities testing, residual solvent limits, and validated analytical methods suitable for complex polyphenolic materials.
Identification & chemistry
| Generic name | Quercetin |
|---|---|
| Molecule type | Small molecule |
| CAS | 117-39-5 |
| UNII | 9IKM0I5T1E |
| DrugBank ID | DB04216 |
Pharmacology
| Summary | Quercetin acts primarily as a quinone reductase 2 inhibitor, disrupting detoxification of quinoline metabolites and promoting oxidative stress in plasmodium. It interacts with a broad set of cellular proteins, including mitochondrial ATP synthase subunits, kinases, nuclear receptors, and metabolic enzymes. These combined target effects reflect its influence on redox balance, energy metabolism, and regulatory signaling pathways. |
|---|---|
| Mechanism of action | Quercetin is a specific quinone reductase 2 (QR2) inhibitor, an enzyme (along with the human QR1 homolog) which catalyzes metabolism of toxic quinolines. Inhibition of QR2 in plasmodium may potentially cause lethal oxidative stress. The inhibition of antioxidant activity in plasmodium may contribute to killing the malaria causing parasites. |
Targets
| Target | Organism | Actions |
|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Humans | |
| UDP-glucuronosyltransferase 3A1 | Humans | |
| ATP synthase subunit alpha, mitochondrial | Humans |
Formulation & handling
- Low aqueous solubility may necessitate solubilization strategies such as solid dispersions or particle‑size reduction for oral formulations.
- As a polyphenolic flavonol with multiple hydroxyl groups, it is prone to oxidation and may require antioxidant protection and controlled processing environments.
- Solid‑state stability can be impacted by humidity, so low‑moisture excipients and protective packaging are typically preferred.
Regulatory status
Supply Chain
| Supply chain summary | Quercetin is a naturally occurring flavonoid rather than a patented pharmaceutical, so there is no originator company or branded prescription product driving its supply landscape. It is produced and distributed globally as a dietary or nutritional ingredient, with packagers such as V Sab Medical Labs Inc. handling finished‑form packaging. Because it has no active patents, the market already functions as an open, multi‑supplier environment with broad generic competition. |
|---|
Quercetin is a type of Herbal remedies
Herbal remedies, a subcategory of pharmaceutical active pharmaceutical ingredients (APIs), refer to medicinal products derived from plants. These remedies have been used for centuries in traditional medicine systems across various cultures worldwide. Herbal remedies harness the therapeutic properties of plant materials such as roots, leaves, flowers, and bark to treat a wide range of health conditions.
Herbal remedies are rich in bioactive compounds, including alkaloids, flavonoids, terpenes, and phenolic acids. These compounds exhibit diverse pharmacological activities and can provide benefits for various ailments. They may possess antioxidant, anti-inflammatory, antimicrobial, antiviral, or immunomodulatory properties, among others.
Pharmaceutical companies extensively research and develop herbal remedies to ensure their safety, efficacy, and standardization. The extraction and purification processes involve techniques such as solvent extraction, steam distillation, and chromatography. Quality control measures are implemented to maintain consistency and potency across batches.
Herbal remedies offer a natural alternative to conventional pharmaceutical drugs and are often preferred by individuals seeking holistic or complementary treatment options. They are commonly available in various forms, including capsules, tablets, tinctures, and topical formulations.
It is essential to note that while herbal remedies are generally considered safe, they can still have interactions with other medications and may not be suitable for everyone. Consulting with healthcare professionals or herbalists before starting any herbal treatment is recommended to ensure proper usage and avoid potential adverse effects.
Overall, herbal remedies within the pharmaceutical API subcategory provide a valuable option for individuals seeking natural alternatives and contribute to the growing field of plant-based medicine.
Quercetin (Herbal remedies), classified under Others
The others category refers to pharmaceutical APIs that do not fall under specific classifications such as antibiotics, antivirals, analgesics, or cardiovascular drugs. These APIs are diverse in nature and serve various therapeutic purposes, making them a crucial component of pharmaceutical formulations.
Pharmaceutical companies develop APIs in the others category to address specific medical conditions or target novel biological pathways. This category includes APIs used in oncology, neurology, immunology, and other specialized areas of medicine. The APIs in this category are often designed to interact with specific molecular targets or receptors, providing targeted therapeutic effects.
The development of APIs in the others category requires extensive research and testing to ensure their efficacy, safety, and compliance with regulatory standards. Pharmaceutical manufacturers employ advanced techniques such as chemical synthesis, biotechnology, and genetic engineering to produce these APIs.
Due to the broad range of applications and therapeutic uses, APIs in the others category contribute significantly to the advancement of medical treatments. Pharmaceutical companies constantly strive to innovate and discover new APIs within this category to address unmet medical needs and improve patient outcomes.
In conclusion, the others category of pharmaceutical APIs encompasses a diverse range of active ingredients used in drug formulation. These APIs play a crucial role in developing innovative therapies across various therapeutic areas, contributing to advancements in healthcare and patient well-being.
Quercetin API manufacturers & distributors
Compare qualified Quercetin API suppliers worldwide. We currently have 2 companies offering Quercetin API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Sichuan Benepure | Producer | China | China | CoA | 23 products |
| Sinoway industrial Co.,Lt... | Distributor | China | China | CoA, ISO9001 | 764 products |
When sending a request, specify which Quercetin API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Quercetin API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
Frequently asked questions about Quercetin API
Sourcing
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Technical
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