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- Ethyl loflazepate
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Ethyl loflazepate | CAS No: 29177-84-2 | GMP-certified suppliers
A medication that provides anxiolytic and sedative effects for central nervous system disorders, primarily used in managing anxiety and related conditions.
Therapeutic categories
Product Snapshot
- Ethyl loflazepate is an oral small molecule available in tablet and film-coated tablet formulations
- It is primarily investigated for anxiolytic and sedative applications
- The compound is currently experimental and not approved by major regulatory agencies
Clinical Overview
Although specific indications and pharmacodynamic data for ethyl loflazepate are not detailed in the available sources, benzodiazepine derivatives are generally utilized for their anxiolytic, muscle relaxant, anticonvulsant, and sedative effects, mediated predominantly through potentiation of gamma-aminobutyric acid (GABA) neurotransmission. This class of compounds typically acts as positive allosteric modulators of the GABA-A receptor, enhancing inhibitory neurotransmission in the CNS. It is reasonable to infer that ethyl loflazepate shares a similar mechanism of action, consistent with its classification, though explicit mechanistic studies are lacking.
Key pharmacokinetic and metabolic profiles for ethyl loflazepate, such as absorption, distribution, metabolism, and excretion (ADME) parameters, have not been well characterized in publicly available data. Benzodiazepines commonly undergo hepatic metabolism via cytochrome P450 enzymes with variable half-lives and active metabolites, factors that influence dosing and safety considerations.
Safety and toxicity information specific to ethyl loflazepate is limited. Benzodiazepines as a class carry risks including sedation, dependence, withdrawal phenomena, respiratory depression, and cognitive impairment, warranting cautious use particularly in vulnerable populations. Given its experimental and illicit status, ethyl loflazepate is not approved by major regulatory agencies, and its clinical use is not established.
From an API procurement perspective, sourcing ethyl loflazepate requires adherence to stringent quality controls given its controlled and investigational nature. Procurement should ensure compliance with applicable legal and regulatory frameworks and prioritize manufacturers employing current good manufacturing practices (cGMP) to ensure batch consistency, purity, and absence of contaminants.
Identification & chemistry
| Generic name | Ethyl loflazepate |
|---|---|
| Molecule type | Small molecule |
| CAS | 29177-84-2 |
| UNII | VJB5FW9W9J |
| DrugBank ID | DB01545 |
Pharmacology
Targets
| Target | Organism | Actions |
|---|---|---|
| GABA(A) Receptor | Humans | positive allosteric modulator |
| GABA(A) Receptor Benzodiazepine Binding Site | Humans | ligand |
Formulation & handling
- Ethyl loflazepate is a small molecule oral drug formulated primarily as tablets, including film-coated forms.
- It exhibits low water solubility and moderate lipophilicity (LogP 3.85), indicating the need for formulation strategies to enhance bioavailability.
- No specific peptide or biologic stability concerns apply, but handling should account for its chemical nature as an alpha amino acid ester derivative.
Regulatory status
Ethyl loflazepate is a type of Hypnotics and sedatives
Hypnotics and sedatives belong to the pharmaceutical API category that plays a crucial role in the field of medicine. These compounds are specifically designed to induce sleep, reduce anxiety, and promote relaxation in patients. With their sedative properties, hypnotics and sedatives are commonly prescribed to treat sleep disorders, insomnia, and certain psychiatric conditions.
Pharmaceutical companies produce hypnotics and sedatives as active pharmaceutical ingredients (APIs), which are the key components responsible for the desired therapeutic effects. These APIs are carefully synthesized and formulated to ensure optimal efficacy and safety in patients. Common examples of hypnotics and sedatives include benzodiazepines, barbiturates, and non-benzodiazepine sedative-hypnotics.
The development of hypnotics and sedatives involves rigorous research and testing to ensure their effectiveness and minimize potential side effects. These APIs work by targeting specific receptors in the central nervous system (CNS), such as GABA receptors, which help regulate neuronal activity and promote sedation. By modulating these receptors, hypnotics and sedatives can produce a calming effect, induce sleep, and alleviate symptoms of anxiety and restlessness.
It is important to note that the use of hypnotics and sedatives should be carefully monitored by healthcare professionals, as they can have potential side effects, such as drowsiness, impaired coordination, and dependence. Additionally, these medications may interact with other drugs, necessitating caution and proper dosage adjustments.
In summary, hypnotics and sedatives are a vital category of pharmaceutical APIs used to promote sleep, reduce anxiety, and induce relaxation. Their precise mechanisms of action on the CNS receptors contribute to their therapeutic effects, making them valuable tools in managing sleep disorders and certain psychiatric conditions.
Ethyl loflazepate API manufacturers & distributors
Compare qualified Ethyl loflazepate API suppliers worldwide. We currently have 1 companies offering Ethyl loflazepate API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Sanofi | Producer | France | France | CoA, GMP | 93 products |
When sending a request, specify which Ethyl loflazepate API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Ethyl loflazepate API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
