Sodium oxybate API Manufacturers
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Looking for Sodium oxybate API 502-85-2?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Sodium oxybate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Sodium oxybate
- Synonyms:
- Natrii oxybas , natrium oxybas
- Cas Number:
- 502-85-2
- DrugBank number:
- DB09072
- Unique Ingredient Identifier:
- 7G33012534
About Sodium oxybate
Do you want to know more about Sodium oxybate? You can find a small explanation about it here. Sodium oxybate (Xyrem) is a central nervous system depressant used for the treatment of cataplexy and extreme daytime sleepiness (EDS) associated with narcolepsy. It is the sodium salt of gamma hydroxybutyric acid (GHB) which is an endogenous compound and a metabolite of the neurotransmitter GABA. The exact mechanism of action for treating EDS and cataplexy is not known but is is hypothesised that its therapeutic effects are due to GABA(B) effects on noradrenergic, dopaminaergic and thalamocorticol neurons.
The drug follows non-linear pharmacokinetics. As it has been associated with misuse/abuse it is strictly controlled and all patients and prescribers must enroll in the sodium oxybate REMs program in order to gain access to the medication.
You can ask the supplier about all relevant certificates for the product such as CoA, Safety Data Sheet and DMF.
Sodium oxybate is a type of Hypnotics
Hypnotics belong to the pharmaceutical API category, which refers to a class of drugs primarily used to induce sleep or alleviate insomnia. These substances act on the central nervous system (CNS) to promote sedation and relaxation, aiding individuals in falling asleep and maintaining a healthy sleep pattern.
Hypnotics work through various mechanisms, targeting receptors and neurotransmitters involved in regulating sleep-wake cycles. They can enhance the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that reduces brain activity and induces sedation. By increasing GABAergic signaling, hypnotics help reduce anxiety, calm the mind, and facilitate sleep onset.
Commonly prescribed hypnotics include benzodiazepines, non-benzodiazepine receptor agonists, and melatonin receptor agonists. Benzodiazepines, such as diazepam and temazepam, bind to GABA receptors, intensifying the inhibitory effects of GABA. Non-benzodiazepine receptor agonists like zolpidem and zopiclone act selectively on certain GABA receptors, inducing sleep without causing significant muscle relaxation or antianxiety effects. Melatonin receptor agonists like ramelteon mimic the effects of melatonin, a hormone that regulates the sleep-wake cycle.
Hypnotics are widely prescribed for individuals experiencing sleep disturbances due to various conditions, including insomnia, jet lag, shift work disorder, or other sleep-related disorders. These APIs are manufactured by pharmaceutical companies and can be formulated into different dosage forms, including tablets, capsules, or liquid preparations.
It's essential to note that the use of hypnotics should be carefully monitored, as prolonged or excessive use may lead to dependence, tolerance, or adverse effects. Therefore, consultation with a healthcare professional is necessary to ensure safe and appropriate use of hypnotics for optimal sleep management.
