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Indirubin-5-sulphonate | CAS No: 244021-67-8 | GMP-certified suppliers

A medication that serves as an experimental compound for research in indole-related biological mechanisms without established therapeutic applications or clinical indications.

Generic name
Indirubin-5-sulphonate
Molecule type
small molecule
CAS number
244021-67-8
DrugBank ID
DB02519
Approval status
Experimental drug

Product Snapshot

  • Indirubin-5-sulphonate is an oral small molecule compound
  • It is primarily investigated for its potential use in oncology and inflammatory conditions
  • The compound is currently in the experimental stage and has not received FDA or EMA approval

Clinical Overview

Indirubin-5-sulphonate (CAS number 244021-67-8) is a chemical compound classified within the indolines, a group of organic molecules characterized by the presence of an indole moiety. The indole structure comprises a pyrrolidine ring fused to a benzene ring, forming 2,3-dihydroindole. This structural class is notable for its relevance in various bioactive molecules.

Currently, Indirubin-5-sulphonate remains an experimental compound with no established clinical indications or approved therapeutic uses. As such, its pharmacodynamics and mechanism of action have not been comprehensively characterized in the literature or regulatory databases. The absence of detailed pharmacological data limits the ability to define its potential clinical application or target pathways.

Information regarding absorption, distribution, metabolism, and excretion (ADME) of Indirubin-5-sulphonate is not readily available. Without such data, predicting its bioavailability, metabolic transformations, or clearance pathways remains speculative. Safety and toxicity profiles have similarly not been established through clinical or preclinical studies, necessitating caution in experimental use and further investigation to determine any adverse effects or risk parameters.

As an experimental compound, Indirubin-5-sulphonate may be utilized primarily within research contexts, such as structure-activity relationship studies or as a chemical probe to explore indole-related biological mechanisms.

For API sourcing and procurement, considerations should include verification of chemical purity, batch consistency, and compliance with relevant pharmacopoeial or regulatory standards where applicable. Suppliers should provide complete characterization data, including impurity profiles and stability information, to support quality assurance in research or development settings. Given the lack of clinical application, sourcing is typically limited to specialized chemical manufacturers or research-grade suppliers.

Identification & chemistry

Generic name Indirubin-5-sulphonate
Molecule type Small molecule
CAS 244021-67-8
DrugBank ID DB02519

Pharmacology

Targets
TargetOrganismActions
Glycogen phosphorylase, muscle formHumans
Cell division control protein 2 homologPlasmodium falciparum (isolate K1 / Thailand)

Formulation & handling

  • Indirubin-5-sulphonate is a small molecule with low water solubility, indicating potential challenges in aqueous formulation development for oral or injectable routes.
  • Its moderate molecular weight and LogP suggest limited lipophilicity, which may impact membrane permeability and formulation strategies for bioavailability enhancement.
  • Due to its classification as an experimental compound, stability and handling protocols should be carefully evaluated under controlled conditions to ensure compound integrity.

Regulatory status