- Raw materials
- Insecticides
- Thiacloprid
Thiacloprid API Manufacturers & Suppliers
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Thiacloprid | CAS No: 111988-49-9 | GMP-certified suppliers
A medication that serves as an insecticide and pesticide for agricultural and industrial use, targeting pest control through neurotoxic effects on insects.
Therapeutic categories
Product Snapshot
- Thiacloprid is an oral small molecule formulation
- Its primary use is as an experimental compound with pesticidal applications
- Thiacloprid does not currently hold FDA or EMA approval for pharmaceutical use
Clinical Overview
From a pharmacological perspective, thiacloprid functions primarily as an agonist at insect nicotinic acetylcholine receptors (nAChRs). It disrupts nerve signal transmission in target insect species, leading to paralysis and death. This mechanism underpins its efficacy as an insecticidal agent, though its relevance to human pharmacology is limited.
Key ADME (absorption, distribution, metabolism, and excretion) parameters relevant to thiacloprid pertain mainly to environmental and toxicological assessments rather than clinical pharmacokinetics. The compound exhibits moderate persistence in environmental matrices, with metabolic biotransformation occurring in various organisms primarily through oxidative pathways. Data on mammalian metabolism and excretion are limited but highlight potential accumulation and toxicity concerns in non-target species.
Thiacloprid carries safety and toxicity considerations primarily related to its neurotoxic effects on insects and potential hazards to non-target organisms, including aquatic life and beneficial insects such as pollinators. Human exposure risks necessitate careful handling and adherence to regulatory guidelines to mitigate toxic actions. Its classification involves sulfur compound chemistry, contributing to its biological activity and environmental behavior.
The compound is found under various brand names and formulations globally as an agricultural pesticide, though regulatory approval status varies by region due to evolving environmental and toxicological data.
For API procurement, sourcing thiacloprid requires stringent quality controls to ensure purity and consistency, given its use in agrochemical formulations. Suppliers should comply with relevant industrial standards and regulatory frameworks governing pesticide manufacture and distribution. Analytical verification of chemical identity and absence of impurities is critical to maintain product safety and efficacy.
Identification & chemistry
| Generic name | Thiacloprid |
|---|---|
| Molecule type | Small molecule |
| CAS | 111988-49-9 |
| UNII | DSV3A944A4 |
| DrugBank ID | DB08620 |
Pharmacology
Targets
| Target | Organism | Actions |
|---|---|---|
| CHRNA7-FAM7A fusion protein | Humans |
Formulation & handling
- Thiacloprid is a small molecule suitable for oral formulation due to its moderate water solubility and LogP.
- Handling of Thiacloprid should consider its solid state and potential sensitivity to moisture to maintain stability.
- Its chemical classification as a 2-halopyridine suggests potential sensitivity to hydrolysis or photodegradation, requiring controlled storage conditions.
Regulatory status
Thiacloprid is a type of Insecticides
Insecticides are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used to control and eradicate insects that pose a threat to human health, agricultural crops, and livestock. These potent chemicals play a crucial role in protecting our environment, ensuring food security, and preventing the spread of insect-borne diseases.
Pharmaceutical APIs in the insecticide category are designed to target specific insects, disrupting their nervous systems, inhibiting their growth, or interfering with their reproductive capabilities. These APIs are formulated into various insecticide formulations, including sprays, baits, powders, and granules, to suit different application methods and target pests.
Insecticides APIs are developed through rigorous research and development processes, adhering to stringent safety and efficacy standards set by regulatory authorities. These APIs undergo extensive testing to ensure their effectiveness, environmental impact, and potential risks to non-target organisms, such as humans and beneficial insects.
The pharmaceutical industry continually strives to enhance insecticide formulations by developing novel APIs with improved efficacy and reduced environmental toxicity. This includes exploring eco-friendly alternatives, such as biopesticides derived from natural sources like bacteria, fungi, or botanical extracts.
The demand for insecticide APIs is driven by the need to protect public health, agricultural productivity, and the global food supply chain. These APIs play a crucial role in controlling harmful insects, preventing economic losses, and mitigating the transmission of insect-borne diseases. Through ongoing research and innovation, the pharmaceutical industry aims to develop safer and more efficient insecticides that minimize environmental impact while effectively combating insect pests.
