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Magnesium lactate | CAS No: 18917-93-6 | GMP-certified suppliers
A medication that provides bioavailable magnesium to support management of magnesium deficiency and related neuromuscular and cardiac functions in mineral supplement formulations.
Therapeutic categories
Product Snapshot
- Magnesium lactate is available as oral tablets and capsules
- It is primarily used for nutritional supplementation to address magnesium deficiency
- The product is approved as a nutraceutical in the Canadian market
Clinical Overview
Although specific clinical indications for magnesium lactate are not uniformly established, magnesium salts, in general, play a role in the management of magnesium deficiency states. Magnesium is a critical cofactor in enzymatic reactions related to energy metabolism, nucleic acid synthesis, and ion transport. As such, magnesium lactate can be included in formulations targeting supportive care for conditions associated with hypomagnesemia.
The pharmacological activity of magnesium lactate centers on the delivery of bioavailable magnesium ions upon dissociation in the gastrointestinal tract. Magnesium ions contribute to neuromuscular transmission, muscle contraction modulation, and cardiac rhythm stabilization. The mechanism of action reflects the physiological roles of magnesium rather than a specific receptor-mediated process.
Data on absorption, distribution, metabolism, and excretion (ADME) specific to magnesium lactate are limited; however, magnesium salts are generally absorbed in the small intestine via passive and active transport mechanisms. Renal excretion regulates systemic magnesium levels, with excess magnesium eliminated primarily through urine, maintaining homeostasis.
Safety considerations for magnesium lactate include the risk of hypermagnesemia, particularly in patients with impaired renal function. Symptoms of magnesium excess may include hypotension, bradycardia, and neuromuscular blockade in severe cases. Appropriate dosing and monitoring are crucial within pharmaceutical and nutraceutical applications.
Magnesium lactate is utilized in various formulations, including mineral supplements and alkalinizing agents. Notable brand names and marketed products may vary regionally, reflecting local regulatory approvals.
When sourcing magnesium lactate APIs, attention should be paid to purity specifications, microbial limits, residual solvents, and compliance with pharmacopeial standards such as USP or EP. Consistency in quality and adherence to Good Manufacturing Practices (GMP) facilitate safe and effective use in formulation development and regulatory submissions.
Identification & chemistry
| Generic name | Magnesium lactate |
|---|---|
| Molecule type | Small molecule |
| CAS | 18917-93-6 |
| UNII | MT6QI8324A |
| DrugBank ID | DB14515 |
Pharmacology
Targets
| Target | Organism | Actions |
|---|---|---|
| Sodium/potassium-transporting ATPase subunit alpha-1 | Humans |
Formulation & handling
- Magnesium lactate is a small molecule suitable for oral administration primarily in tablet or capsule form.
- It exhibits high water solubility, facilitating formulation in immediate or controlled-release oral dosage forms.
- Handling considerations include protection from moisture due to its hygroscopic nature to maintain stability.
Regulatory status
| Lifecycle | The API is currently marketed in Canada with patent protection set to expire within the next 12 months, indicating an impending transition toward increased generic competition and market maturity. Post-patent expiry, market dynamics are expected to evolve as additional manufacturers enter the market. |
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| Markets | Canada |
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Supply Chain
| Supply chain summary | The manufacturing landscape for magnesium lactate in Canada includes originator companies producing branded products such as Magnesium Lactate Cap 70mg. The product has presence primarily in the Canadian market, with limited information on broader US or EU distribution. Patent expiry status suggests that generic competition may already be present or forthcoming in this segment. |
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Magnesium Lactate is a type of Magnesium Salts
Magnesium salts are a crucial subcategory of active pharmaceutical ingredients (APIs) widely used in the pharmaceutical industry. These salts are compounds formed by combining magnesium with other chemical elements or groups. Magnesium salts are highly valued for their therapeutic properties and play a significant role in various medical applications.
One of the most well-known magnesium salts is magnesium oxide, which is commonly used as a supplement to treat magnesium deficiency in the body. This salt is known for its high bioavailability, making it an effective option for oral administration.
Another important magnesium salt is magnesium sulfate, which finds extensive use in both pharmaceutical and medical settings. It is often utilized in the treatment of conditions such as eclampsia, pre-eclampsia, and magnesium deficiency in pregnant women. Magnesium sulfate can be administered intravenously or orally, depending on the specific medical requirements.
Furthermore, magnesium citrate, a salt formed by combining magnesium with citric acid, is renowned for its laxative properties. It is frequently employed in the formulation of bowel preparations to facilitate bowel movements before medical procedures or surgeries.
The versatility of magnesium salts extends beyond medical applications. They are also utilized in the manufacturing of antacids, laxatives, and various over-the-counter products.
In conclusion, magnesium salts form a significant subcategory of pharmaceutical APIs, offering a wide range of therapeutic benefits. These salts, including magnesium oxide, magnesium sulfate, and magnesium citrate, play vital roles in treating magnesium deficiencies, supporting pregnancy-related conditions, and aiding bowel movements. Their extensive usage and efficacy make them indispensable components in the pharmaceutical industry.
Magnesium Lactate (Magnesium Salts), classified under Therapeutic Nutrients/Minerals/Electrolyte
Therapeutic Nutrients/Minerals/Electrolytes: A Comprehensive Technical DescriptionTherapeutic nutrients, minerals, and electrolytes are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used to support and enhance overall health and well-being. These compounds play a crucial role in maintaining the body's physiological balance, aiding in various metabolic processes, and addressing specific deficiencies.
Therapeutic nutrients encompass a broad range of substances, including vitamins, minerals, and electrolytes. Vitamins are organic compounds required in small quantities for proper bodily functions and are essential for growth, development, and disease prevention. Minerals, on the other hand, are inorganic substances that support numerous physiological processes, such as bone formation, nerve function, and energy production.
Electrolytes are minerals that carry an electric charge when dissolved in bodily fluids, including sodium, potassium, calcium, magnesium, and chloride. They play a crucial role in maintaining proper hydration, nerve impulses, muscle contractions, and pH balance.
Pharmaceutical APIs in the Therapeutic Nutrients/Minerals/Electrolyte category are designed to address specific deficiencies or imbalances in the body. These APIs are often used in the formulation of dietary supplements, nutritional products, and therapeutic treatments. They are manufactured under stringent quality control guidelines to ensure purity, potency, and bioavailability.
Therapeutic nutrients/minerals/electrolytes APIs are available in various forms, including tablets, capsules, powders, and liquid formulations. They are formulated to meet specific dosage requirements and can be combined with other ingredients for targeted health benefits.
Overall, therapeutic nutrients, minerals, and electrolytes APIs are essential components in maintaining optimal health. Their use helps address deficiencies, support bodily functions, and promote overall well-being. Pharmaceutical companies and healthcare professionals rely on these high-quality APIs to develop effective and safe products that contribute to a healthier population.
Magnesium Lactate API manufacturers & distributors
Compare qualified Magnesium Lactate API suppliers worldwide. We currently have 4 companies offering Magnesium Lactate API, with manufacturing taking place in 4 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Acta minerals | Producer | Netherlands | Netherlands | BSE/TSE, CoA, GMP, MSDS | 67 products |
| Farmak | Producer | Czech Republic | Czech Republic | CoA, GMP | 19 products |
| Jost Chemical | Producer | United States | United States | CoA, USDMF | 14 products |
| Moehs | Producer | Spain | Spain | CoA, EDMF/ASMF, GMP | 50 products |
When sending a request, specify which Magnesium Lactate API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Magnesium Lactate API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
