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Phenacetin API from Chinese Manufacturers & Suppliers
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Phenacetin | CAS No: 62-44-2 | GMP-certified suppliers
A medication that provides non‑narcotic relief for mild to moderate pain and fever, supporting sourcing needs for analgesic formulations in relevant therapeutic applications.
Therapeutic categories
Primary indications
- Used principally as an analgesic
Product Snapshot
- Phenacetin is an oral small‑molecule analgesic compound
- Its primary historical use was for pain relief
- It is withdrawn from major regulatory markets and is not FDA or EMA approved
Clinical Overview
Pharmacologically, phenacetin exerts central analgesic effects and has been described as acting at the spinal cord level to modulate nociceptive processing. It also demonstrates negative inotropic activity, although this effect did not constitute its therapeutic intent. Reported historical uses included symptomatic treatment of subacute rheumatoid arthritis, intercostal neuralgia, and certain ataxic conditions. Phenacetin is a substrate for several cytochrome P450 isoenzymes, including CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, and CYP3A4, indicating extensive hepatic biotransformation. A portion of its activity is attributable to metabolic conversion to acetaminophen.
The mechanism of action has not been fully defined. Available evidence indicates involvement of central prostaglandin synthesis modulation via its metabolite, but phenacetin itself shows distinct pharmacodynamic characteristics compared with acetaminophen.
ADME characteristics include oral absorption with hepatic metabolism through multiple oxidative pathways, followed by renal elimination of metabolites. The compound is also reported to inhibit OAT1/SLC22A6, which may influence renal handling of coadministered substrates.
Safety concerns have centered on cumulative renal toxicity, including papillary necrosis and chronic interstitial nephritis associated with long‑term use. Epidemiological data also link prolonged exposure to increased risks of urothelial malignancy when used in certain combination analgesic formulations. These findings prompted global regulatory withdrawal. Residual use today is limited to historical context and analytical reference applications.
Phenacetin was previously incorporated into branded combination analgesic products, though no therapeutic products remain authorized. For API procurement, sourcing should focus on verified analytical‑grade material, ensuring full compliance with regional controls due to its withdrawn status and safety profile.
Identification & chemistry
| Generic name | Phenacetin |
|---|---|
| Molecule type | Small molecule |
| CAS | 62-44-2 |
| UNII | ER0CTH01H9 |
| DrugBank ID | DB03783 |
Pharmacology
| Summary | Phenacetin exerts analgesic and antipyretic effects primarily through inhibition of prostaglandin G/H synthase 1, reducing prostaglandin‑mediated pain and fever signaling. Its activity includes central analgesic actions at the spinal cord and negative inotropic effects on cardiac tissue. Therapeutically, it has been used for pain relief in conditions such as subacute rheumatoid arthritis and certain neuralgias. |
|---|---|
| Pharmacodynamics | Phenacetin was the first NSAID and fever reducer to go on the market. It acts as an analgesic at the spinal cord as well as a negative inotrope at the heart. It can be used to treat subacute rheumatoid arthritis, intercostal neuralgia, and ataxias. |
Targets
| Target | Organism | Actions |
|---|---|---|
| Prostaglandin G/H synthase 1 | Humans |
ADME / PK
| Metabolism | Metabolised in the body to paracetamol. |
|---|
Formulation & handling
- Moderate aqueous solubility and small‑molecule properties support conventional oral solid‑dose formulations, though dissolution enhancement may be required for consistent performance.
- Solid-state stability is generally good, but control of particle size and avoidance of moisture uptake are useful for ensuring uniformity in bulk handling.
- Withdrawn status limits therapeutic use, but material may still be handled in R&D settings with standard controls for aromatic acetanilides.
Regulatory status
Safety
| Toxicity | Acute oral toxicity (LD50): 866 mg/kg [Mouse]. |
|---|
- Exhibits moderate acute oral toxicity (mouse LD50 ~866 mg/kg), indicating the need for controlled exposure in manufacturing environments
- High-dose exposure may be associated with CNS and hepatic stress responses typical of small‑molecule analgesics
- Dust or concentrated material may pose irritation or systemic toxicity risks if accidentally ingested or inhaled during handling
Phenacetin is a type of Non-opioid analgesics
Non-opioid analgesics are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that are widely used for the management of pain. Unlike opioids, which are known to have addictive properties, non-opioid analgesics offer pain relief without the risk of dependence or addiction.
These APIs work by inhibiting the production of prostaglandins, which are substances in the body that contribute to pain and inflammation. Non-opioid analgesics are typically available over-the-counter (OTC) and come in various forms such as tablets, capsules, creams, and gels.
One of the most common non-opioid analgesics is acetaminophen, which is highly effective in relieving mild to moderate pain. It is commonly used to alleviate headaches, toothaches, and musculoskeletal pain. Another popular non-opioid analgesic is non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen. These medications not only reduce pain but also have anti-inflammatory properties, making them particularly useful for conditions such as arthritis.
Non-opioid analgesics are generally well-tolerated but can have potential side effects, including gastrointestinal disturbances and, in rare cases, liver or kidney damage. It is important to follow recommended dosages and consult a healthcare professional if there are any concerns or underlying medical conditions.
In conclusion, non-opioid analgesics are a vital category of pharmaceutical APIs that offer effective pain relief without the risk of addiction. Their accessibility, diverse formulations, and relatively favorable safety profile make them a popular choice for individuals seeking relief from various types of pain.
Phenacetin (Non-opioid analgesics), classified under Analgesics
Analgesics are a category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that are commonly used to relieve pain. They are designed to alleviate discomfort by targeting the body's pain receptors or by reducing inflammation. Analgesics are widely utilized in the medical field to manage various types of pain, ranging from mild to severe.
One of the primary classes of analgesics is nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by inhibiting the production of prostaglandins, substances that contribute to pain and inflammation. This class includes well-known drugs like ibuprofen and naproxen. Another class of analgesics is opioids, which are derived from opium or synthetic compounds that mimic the effects of opium. Opioids act on the central nervous system to reduce pain perception and provide potent pain relief. Examples of opioids include morphine, codeine, and oxycodone.
Analgesics are available in various forms, such as tablets, capsules, creams, and injections, allowing for different routes of administration based on the patient's needs. They are commonly used to manage pain associated with conditions like arthritis, headaches, dental procedures, and post-operative recovery.
It is important to note that analgesics should be used under medical supervision, as improper use or overuse can lead to adverse effects, including gastrointestinal complications, addiction, and respiratory depression in the case of opioids. Therefore, it is crucial for healthcare professionals to assess each patient's individual needs and prescribe the appropriate analgesic and dosage.
In summary, analgesics are a vital category of pharmaceutical APIs used to alleviate pain by targeting pain receptors or reducing inflammation. With various classes and forms available, they provide valuable options for pain management when used responsibly and under medical guidance.
Phenacetin API manufacturers & distributors
Compare qualified Phenacetin API suppliers worldwide. We currently have 2 companies offering Phenacetin API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Aurora Industry Co., Ltd | Distributor | China | China | BSE/TSE, CEP, CoA, FDA, GMP, ISO9001, MSDS, USDMF, WC | 250 products |
| Nantong Jinghua | Producer | China | China | CoA, GMP | 12 products |
When sending a request, specify which Phenacetin API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Phenacetin API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
Frequently asked questions about Phenacetin API
Sourcing
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Technical
What is Phenacetin (CAS 62-44-2) used for?
Which therapeutic class does Phenacetin fall into?
What conditions is Phenacetin mainly prescribed for?
How does Phenacetin work?
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What are important formulation and handling considerations for Phenacetin as an API?
Is Phenacetin a small molecule?
Are there special stability concerns for oral Phenacetin?
Pharmaoffer
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