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Clonixin | CAS No: 17737-65-4 | GMP-certified suppliers
A medication that manages pain and inflammation in chronic arthritic and soft tissue disorders, offering analgesic and anti-inflammatory effects within NSAID therapeutic classes.
Therapeutic categories
Primary indications
- Indicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation
Product Snapshot
- Clonixin is available in multiple formulation types including oral tablets, capsules, parenteral solutions, topical gels, and injectable forms
- It is primarily used for the management of chronic arthritic conditions and soft tissue disorders associated with pain and inflammation
- Clonixin is currently in the experimental stage and not yet approved by major regulatory agencies such as FDA or EMA
Clinical Overview
Pharmacodynamically, clonixin exerts vasodilatory and analgesic effects, aligning with the typical NSAID profile. Although its precise molecular mechanism has not been thoroughly investigated, it is generally presumed to inhibit cyclooxygenase enzymes COX-1 and COX-2. This inhibition leads to a decrease in prostaglandin synthesis, which in turn reduces inflammation and pain signaling.
Clonixin shares structural similarity with other NSAIDs, suggesting overlap in pharmacological activity. Key absorption, distribution, metabolism, and excretion (ADME) parameters specific to clonixin are not well-documented, limiting detailed pharmacokinetic characterization. Its use remains experimental and is not widely approved for clinical application under major regulatory authorities.
Safety considerations for clonixin should reflect those common to non-selective NSAIDs. These include potential risks of nephrotoxicity, hypertension, and disturbances in electrolyte balance such as hyperkalemia. Its classification also indicates it may affect peripheral sensory systems. Careful monitoring is advisable when considering therapy involving clonixin, especially in patients with preexisting renal, cardiovascular, or electrolyte disorders.
Currently, there are no notable marketed brand names for clonixin, and its clinical utilization is limited to experimental contexts. For formulation development and API sourcing, manufacturers should ensure compliance with pharmacopeial standards for purity, particle size, and stability. Rigorous quality control is essential to address the potential for nephrotoxic impurities and ensure batch-to-batch consistency in the absence of widespread regulatory guidance.
Identification & chemistry
| Generic name | Clonixin |
|---|---|
| Molecule type | Small molecule |
| CAS | 17737-65-4 |
| UNII | V7DXN0M42R |
| DrugBank ID | DB09218 |
Pharmacology
| Summary | Clonixin is a non-steroidal anti-inflammatory drug (NSAID) that exerts its effects primarily through the inhibition of cyclooxygenase enzymes COX-1 and COX-2, leading to reduced prostaglandin synthesis. Its pharmacodynamic profile includes analgesic and vasodilatory actions. Clonixin is utilized for managing chronic arthritic conditions and soft tissue disorders associated with pain and inflammation. |
|---|---|
| Mechanism of action | The mechanism of clonixin does not appear to have been investigated on a molecular level. It is presumed to function similarly to other NSAIDs by inhibiting cycloxygenase enzymes 1 and 2 resulting in a reduction in prostaglandin production. |
| Pharmacodynamics | Clonixin is a non-steroidal anti-inflammatory drug (NSAID) similar in structure to [DB00586]. It produces vasodilation and analgesia. |
Formulation & handling
- Clonixin is a small molecule drug suitable for multiple administration routes including oral, parenteral, and topical formulations.
- Its moderate lipophilicity (LogP 3.42) and low aqueous solubility may require formulation strategies to enhance bioavailability.
- Handling should consider its solid state and potential stability concerns in aqueous solutions for injectable use.
Regulatory status
Clonixin is a type of NSAIDs
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are a widely used subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs). These medications are commonly prescribed for their analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties. NSAIDs work by inhibiting the production of certain enzymes called cyclooxygenases (COX), which play a crucial role in the synthesis of prostaglandins, substances that contribute to pain, inflammation, and fever.
These pharmaceutical APIs are available in various formulations, including tablets, capsules, creams, and gels, making them convenient for different administration routes. Some popular examples of NSAIDs include aspirin, ibuprofen, naproxen, and diclofenac.
NSAIDs are commonly used to treat a wide range of conditions such as arthritis, musculoskeletal injuries, dental pain, menstrual pain, and headaches. They are also effective in managing inflammatory conditions like rheumatoid arthritis and ankylosing spondylitis.
While NSAIDs are generally safe and effective when used as directed, they may have side effects. These can include gastrointestinal issues such as stomach ulcers or bleeding, cardiovascular risks, and kidney problems. Therefore, it is essential to follow the recommended dosage and consult with healthcare professionals to ensure proper and safe usage.
In conclusion, NSAIDs are a subcategory of pharmaceutical APIs that offer analgesic, anti-inflammatory, and antipyretic properties. Their versatility and effectiveness in treating various conditions make them widely prescribed medications. However, it is crucial to be aware of potential side effects and consult healthcare providers for appropriate usage.
Clonixin (NSAIDs), classified under Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
Clonixin API manufacturers & distributors
Compare qualified Clonixin API suppliers worldwide. We currently have 3 companies offering Clonixin API, with manufacturing taking place in 3 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Pen Tsao Chemical Industr... | Producer | Germany | China | CoA | 18 products |
| Samhwa Biopharm co.,ltd | Producer | South Korea | South Korea | BSE/TSE, CoA, GMP, MSDS | 17 products |
| Triquim | Producer | Argentina | Argentina | CoA, GMP, ISO9001 | 16 products |
When sending a request, specify which Clonixin API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
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