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Tiaprofenic acid | CAS No: 33005-95-7 | GMP-certified suppliers
A medication that provides analgesic and anti-inflammatory effects for managing arthritic and musculoskeletal pain with non-steroidal properties suitable for pharmaceutical API sourcing.
Therapeutic categories
Primary indications
- Tiaprofenic acid is used to treat pain, especially arthritic pain
Product Snapshot
- Tiaprofenic acid is available in multiple oral formulations including tablets, capsules (including extended release), granules, suppositories, and injectable powder for solution
- It is primarily indicated for the management of pain, with a focus on arthritic pain relief
- This API is approved for use in the Canadian pharmaceutical market
Clinical Overview
Pharmacologically, tiaprofenic acid exerts its effects by inhibiting the cyclooxygenase (COX) enzymes involved in converting arachidonic acid to prostaglandins. These prostaglandins mediate inflammatory responses such as pain, swelling, and fever. By suppressing prostaglandin production, tiaprofenic acid reduces the clinical symptoms associated with arthritis and other inflammatory conditions. The typical adult dosing regimen is 300 mg administered twice daily, while use in pediatric populations is generally not recommended due to insufficient safety data.
Key pharmacokinetic parameters include absorption, metabolism, and excretion, although specific details vary depending on formulation and patient factors. Tiaprofenic acid is metabolized primarily by the liver and eliminated via the kidneys. Like other NSAIDs, it has notable safety considerations, including the potential for nephrotoxicity, gastrointestinal irritation, and photosensitivity. It may also contribute to adverse cardiovascular effects such as hypertension and hyperkalemia, necessitating caution in vulnerable patient groups.
Tiaprofenic acid is classified chemically as an aryl-phenylketone, an organic compound characterized by an aromatic ketone structure substituted with aryl and phenyl groups. It is marketed under various brand names worldwide, primarily for managing musculoskeletal and inflammatory pain.
From a sourcing and quality perspective, procurement of tiaprofenic acid API requires adherence to strict regulatory standards to ensure purity, potency, and consistent pharmacological activity. Suppliers should provide comprehensive certificates of analysis, and material must conform to pharmacopeial specifications where applicable. Given the safety profile of NSAIDs, stringent control of impurities and stability is critical for manufacturing compliance and patient safety.
Identification & chemistry
| Generic name | Tiaprofenic acid |
|---|---|
| Molecule type | Small molecule |
| CAS | 33005-95-7 |
| UNII | 1LS1T6R34C |
| DrugBank ID | DB01600 |
Pharmacology
| Summary | Tiaprofenic acid is a non-steroidal anti-inflammatory drug (NSAID) of the arylpropionic acid class that exerts therapeutic effects by inhibiting prostaglandin G/H synthase 1 and 2 enzymes. This inhibition reduces prostaglandin synthesis, leading to decreased inflammation, pain, and swelling. It is primarily indicated for the management of pain associated with arthritic conditions. |
|---|---|
| Mechanism of action | Tiaprofenic acid belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of a chemical (prostaglandin) which the body produces in response to injury or certain diseases. This prostaglandin would otherwise go on to cause swelling, pain and inflammation. |
| Pharmacodynamics | Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. This drug is not recommended for use in the pediatric population. |
Targets
| Target | Organism | Actions |
|---|---|---|
| Prostaglandin G/H synthase 1 | Humans | inhibitor |
| Prostaglandin G/H synthase 2 | Humans | inhibitor |
ADME / PK
| Absorption | Bioavailability is 90% following oral administration. |
|---|---|
| Half-life | 1.5-2.5 hours |
| Metabolism | Hepatic (10%). Sparingly metabolised in the liver to two inactive metabolites. |
Formulation & handling
- Tiaprofenic acid is a small molecule available in various oral dosage forms and as an intramuscular injection.
- The API exhibits low water solubility and moderate lipophilicity (LogP 3.66), which may influence formulation strategies.
- Oral administration should consider food effects; formulations need to support administration with food and avoid alcohol interactions.
Regulatory status
| Lifecycle | The API’s primary patent protection in Canada has expired, allowing for generic entry and increased market competition. As a result, the product is in a mature phase with multiple approved generic formulations available. |
|---|
| Markets | Canada |
|---|
Supply Chain
| Supply chain summary | Tiaprofenic acid has several branded products available in the Canadian market, indicating presence by multiple originator companies or licensees. The market appears focused on immediate-release and sustained-release formulations at 200 mg and 300 mg dosages. Patent expiry status is not specified, but availability of multiple branded generics suggests existing generic competition in the region. |
|---|
Tiaprofenic acid is a type of NSAIDs
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are a widely used subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs). These medications are commonly prescribed for their analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties. NSAIDs work by inhibiting the production of certain enzymes called cyclooxygenases (COX), which play a crucial role in the synthesis of prostaglandins, substances that contribute to pain, inflammation, and fever.
These pharmaceutical APIs are available in various formulations, including tablets, capsules, creams, and gels, making them convenient for different administration routes. Some popular examples of NSAIDs include aspirin, ibuprofen, naproxen, and diclofenac.
NSAIDs are commonly used to treat a wide range of conditions such as arthritis, musculoskeletal injuries, dental pain, menstrual pain, and headaches. They are also effective in managing inflammatory conditions like rheumatoid arthritis and ankylosing spondylitis.
While NSAIDs are generally safe and effective when used as directed, they may have side effects. These can include gastrointestinal issues such as stomach ulcers or bleeding, cardiovascular risks, and kidney problems. Therefore, it is essential to follow the recommended dosage and consult with healthcare professionals to ensure proper and safe usage.
In conclusion, NSAIDs are a subcategory of pharmaceutical APIs that offer analgesic, anti-inflammatory, and antipyretic properties. Their versatility and effectiveness in treating various conditions make them widely prescribed medications. However, it is crucial to be aware of potential side effects and consult healthcare providers for appropriate usage.
Tiaprofenic acid (NSAIDs), classified under Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
Tiaprofenic acid API manufacturers & distributors
Compare qualified Tiaprofenic acid API suppliers worldwide. We currently have 3 companies offering Tiaprofenic acid API, with manufacturing taking place in 3 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Erregierre | Producer | Italy | Italy | CoA, GMP | 44 products |
| Mylan | Producer | India | India | CEP, CoA, WC | 201 products |
| Sanofi | Producer | France | Unknown | CEP, CoA, FDA, GMP | 93 products |
When sending a request, specify which Tiaprofenic acid API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Tiaprofenic acid API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
