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Aprindine | CAS No: 37640-71-4 | GMP-certified suppliers
A medication that manages cardiac arrhythmias by modulating sodium channels to stabilize abnormal heart rhythms in cardiovascular therapy.
Therapeutic categories
Product Snapshot
- Aprindine is an oral small molecule antiarrhythmic agent
- It is primarily used for the management of cardiac arrhythmias
- Aprindine currently holds experimental status and is not approved by major regulatory authorities such as the FDA or EMA
Clinical Overview
Primarily investigated as a cardiac depressant, aprindine is utilized experimentally in the management of cardiac arrhythmias. Its pharmacological action involves inhibition of sodium influx during the cardiac action potential, leading to a decrease in cardiac excitability and conduction velocity. This mechanism targets the normalization of aberrant electrical impulses within myocardial tissue, although detailed pharmacodynamic profiles specific to aprindine remain limited.
Pharmacokinetic data for aprindine are sparse but it is known to be a substrate of cytochrome P450 enzymes, notably CYP2D6. This metabolic pathway indicates potential for clinically relevant drug-drug interactions and variable metabolism among individuals with different CYP2D6 genotypes. Absorption, distribution, metabolism, and excretion parameters have not been fully characterized, and no definitive dosing or bioavailability profiles have been established in the literature.
Safety and toxicity information is insufficient, and aprindine's regulatory status remains experimental. There are no widely recognized branded formulations currently approved for routine clinical use. Caution is advised due to the lack of comprehensive safety data and the potential proarrhythmic risks inherent to class I antiarrhythmics.
From a sourcing perspective, procurement of aprindine active pharmaceutical ingredient (API) should consider compliance with Good Manufacturing Practice (GMP) standards, given its experimental status. Quality assessments must focus on purity, polymorphic form, and stability to ensure reproducibility in formula development. Verification of supplier regulatory certification and thorough impurity profiling are recommended to mitigate risks in manufacturing and clinical application.
Identification & chemistry
| Generic name | Aprindine |
|---|---|
| Molecule type | Small molecule |
| CAS | 37640-71-4 |
| UNII | 5Y48085P9Q |
| DrugBank ID | DB01429 |
Pharmacology
Targets
| Target | Organism | Actions |
|---|---|---|
| Sodium channel protein type 5 subunit alpha | Humans | inhibitor |
| Calmodulin | Humans | inhibitor |
Formulation & handling
- Aprindine is a small molecule with low water solubility, indicating the need for solubilization strategies in oral or injectable formulations.
- The high LogP value suggests significant lipophilicity, requiring consideration of lipid-based delivery systems or appropriate excipients to enhance bioavailability.
- As a stable solid with no peptide or biologic elements, Aprindine does not present inherent sensitivity to food or enzymatic degradation.
Regulatory status
Aprindine is a type of Other anti-arrhythmics
Others
Aprindine (Other anti-arrhythmics), classified under Anti-arrhythmics
Anti-arrhythmics belong to the pharmaceutical API category designed to treat irregular heart rhythms, also known as arrhythmias. These medications work by targeting the electrical signals in the heart, helping to regulate the heart's rhythm and restore it to a normal, steady beat.
Anti-arrhythmics are crucial in managing various types of arrhythmias, such as atrial fibrillation, ventricular tachycardia, and supraventricular tachycardia. These conditions can pose serious risks, including an increased likelihood of stroke or heart failure. Hence, anti-arrhythmics play a vital role in improving patient outcomes and reducing these associated risks.
Pharmaceutical companies develop anti-arrhythmic APIs, which are the active ingredients used to formulate the final medications. These APIs undergo rigorous testing and quality control measures to ensure their safety, efficacy, and consistent performance. They are manufactured in accordance with Good Manufacturing Practices (GMP) guidelines to meet the highest quality standards.
Healthcare professionals prescribe anti-arrhythmics based on the specific arrhythmia type, severity, and individual patient factors. These APIs can be formulated into different dosage forms, including tablets, capsules, or intravenous solutions, depending on the desired route of administration and patient requirements.
It is important to note that anti-arrhythmics are prescription-only medications and should only be used under medical supervision. Patients using these medications must follow their healthcare provider's instructions and regularly monitor their heart rhythm to ensure optimal treatment effectiveness and minimize potential side effects.
In conclusion, anti-arrhythmics are a crucial category of pharmaceutical APIs used to treat various types of irregular heart rhythms. They are formulated into medications that help regulate the heart's electrical signals, reduce associated risks, and improve patient outcomes.
Aprindine API manufacturers & distributors
Compare qualified Aprindine API suppliers worldwide. We currently have 1 companies offering Aprindine API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Zydus Takeda Healthcare | Producer | India | India | CoA, WC | 7 products |
When sending a request, specify which Aprindine API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Aprindine API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
