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Myristic acid | CAS No: 544-63-8 | GMP-certified suppliers
A medication that serves as a saturated long-chain fatty acid for incorporation into lipid-based formulations, supporting research and development in lipid metabolism and membrane biology.
Therapeutic categories
Product Snapshot
- Myristic acid is available as a topical liquid and injectable foam formulation
- It is primarily used in experimental applications without established therapeutic indications
- This compound is currently in experimental status with no formal FDA approval in the US market
Clinical Overview
Clinical indications for myristic acid have not been established, and it remains classified as an experimental compound without approved pharmaceutical applications. Its pharmacological activity, mechanism of action, and pharmacodynamics have not been clearly defined in the scientific literature. However, long-chain fatty acids like myristic acid are known to be involved in various biological processes including cellular membrane composition and post-translational protein modification through myristoylation.
Regarding absorption, distribution, metabolism, and excretion (ADME), myristic acid is typically absorbed in the gastrointestinal tract when ingested as part of dietary lipids. It undergoes metabolic degradation primarily via beta-oxidation in mitochondria to yield energy, and it can be incorporated into complex lipids and biological membranes. The compound exhibits typical physicochemical properties of saturated fatty acids which influence its bioavailability and metabolism.
Safety and toxicity data specific to isolated myristic acid are limited. As a naturally occurring fatty acid found in various animal and plant fats, it is generally considered to have low acute toxicity. However, its impact on lipid metabolism and cardiovascular health in the context of pharmaceutical or supplemental use has not been fully elucidated, necessitating cautious interpretation for any potential applications.
Myristic acid does not correspond to any established pharmaceutical products or marketed brands. In formulation and API sourcing, attention should be given to purity standards consistent with fatty acid pharmacopoeial monographs. Potential impurities such as peroxides or residual solvents should be controlled to ensure quality and compliance with regulatory requirements. Reliable supply chains and certificate of analysis verification are recommended for consistent procurement.
Identification & chemistry
| Generic name | Myristic acid |
|---|---|
| Molecule type | Small molecule |
| CAS | 544-63-8 |
| UNII | 0I3V7S25AW |
| DrugBank ID | DB08231 |
Pharmacology
Targets
| Target | Organism | Actions |
|---|---|---|
| Genome polyprotein | Poliovirus type 1 (strain Mahoney) | |
| Genome polyprotein | HRV-16 | |
| Genome polyprotein | HRV-1A |
Formulation & handling
- Myristic acid is a small molecule long-chain fatty acid primarily intended for topical application, not suitable for oral or injectable systemic use.
- Due to its low water solubility and high lipophilicity (LogP 5.37), formulation strategies should focus on enhancing dermal penetration and stability in lipid-based vehicles.
- Handle under standard laboratory conditions, as it is a stable solid with no special sensitivity to food or moisture reported.
Regulatory status
| Lifecycle | The active pharmaceutical ingredient (API) is currently off-patent in the US, allowing for generic competition and widespread market availability. Market maturity is established with multiple manufacturers supplying the API. |
|---|
| Markets | US |
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Supply Chain
| Supply chain summary | The supply landscape for Myristic acid includes several originator companies producing branded products primarily in the US market. The presence of branded formulations such as Jayjun Real Water masks indicates active brand participation. Patent expiry status is not specified, so the extent of generic competition cannot be determined from the available data. |
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MYRISTIC ACID is a type of Surfactants
Surfactants play a crucial role in the pharmaceutical industry as an essential subcategory of active pharmaceutical ingredients (APIs). These compounds, known as surface-active agents, are widely used for their unique properties in pharmaceutical formulations. Surfactants possess both hydrophilic (water-loving) and hydrophobic (water-repelling) regions, allowing them to reduce surface tension and enhance solubility.
In pharmaceutical applications, surfactants serve multiple purposes. They are utilized as emulsifiers, aiding in the creation of stable emulsions by dispersing immiscible substances such as oil and water. This property is particularly valuable in the production of oral suspensions and topical creams.
Surfactants also act as wetting agents, facilitating the uniform distribution of a liquid across solid surfaces. This property is beneficial for drug manufacturing processes, as it ensures consistent dissolution and optimal bioavailability of the active ingredient.
Furthermore, surfactants serve as foaming agents in various pharmaceutical products, such as liquid soaps and mouthwashes. They enhance foam formation and stability, improving the cleansing and emollient effects of these formulations.
Additionally, surfactants are used to modify the permeability of biological membranes, enabling the enhanced absorption of drugs through the skin or mucosal surfaces. This property is particularly valuable in transdermal drug delivery systems and nasal sprays.
The pharmaceutical industry relies on surfactants due to their versatile properties, including emulsification, wetting, foaming, and membrane permeability modification. Their incorporation in various formulations enhances the performance, stability, and therapeutic efficacy of pharmaceutical products.
MYRISTIC ACID (Surfactants), classified under Additives
Additives in the pharmaceutical API category refer to a group of chemical substances that are incorporated into pharmaceutical products to enhance their stability, functionality, or performance. These additives play a crucial role in ensuring the quality, safety, and efficacy of medications.
One common type of additive used in pharmaceuticals is preservatives. Preservatives are added to prevent microbial growth and maintain the integrity of the product throughout its shelf life. They help to safeguard against contamination and maintain the potency of the active pharmaceutical ingredient (API). Some commonly used preservatives include benzyl alcohol, phenol, and parabens.
Another important group of additives is antioxidants. Antioxidants are added to pharmaceutical formulations to prevent or delay the oxidation of APIs, which can lead to degradation and loss of potency. Examples of antioxidants commonly used in pharmaceuticals include ascorbic acid (vitamin C) and tocopherols (vitamin E).
In addition to preservatives and antioxidants, other additives like flavorings, colorants, and sweeteners may be incorporated into pharmaceutical products to improve their palatability and patient acceptability.
It is crucial to note that the use of additives in pharmaceuticals is strictly regulated by health authorities to ensure their safety and efficacy. Manufacturers must comply with stringent quality control standards and guidelines to guarantee the proper use and appropriate levels of additives in pharmaceutical products.
Overall, additives play a vital role in the pharmaceutical industry by enhancing the stability, functionality, and patient acceptability of medications. Their careful selection and incorporation contribute to the overall quality and effectiveness of pharmaceutical products.
