Poloxamer 188 API Manufacturers

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Here you will find a list of producers, manufacturers and distributors of Poloxamer 188. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Poloxamer 188 

Synonyms:

Kolliphor P188  

Poloxamer 188 is a type of Surfactants

Surfactants play a crucial role in the pharmaceutical industry as an essential subcategory of active pharmaceutical ingredients (APIs). These compounds, known as surface-active agents, are widely used for their unique properties in pharmaceutical formulations. Surfactants possess both hydrophilic (water-loving) and hydrophobic (water-repelling) regions, allowing them to reduce surface tension and enhance solubility.

In pharmaceutical applications, surfactants serve multiple purposes. They are utilized as emulsifiers, aiding in the creation of stable emulsions by dispersing immiscible substances such as oil and water. This property is particularly valuable in the production of oral suspensions and topical creams.

Surfactants also act as wetting agents, facilitating the uniform distribution of a liquid across solid surfaces. This property is beneficial for drug manufacturing processes, as it ensures consistent dissolution and optimal bioavailability of the active ingredient.

Furthermore, surfactants serve as foaming agents in various pharmaceutical products, such as liquid soaps and mouthwashes. They enhance foam formation and stability, improving the cleansing and emollient effects of these formulations.

Additionally, surfactants are used to modify the permeability of biological membranes, enabling the enhanced absorption of drugs through the skin or mucosal surfaces. This property is particularly valuable in transdermal drug delivery systems and nasal sprays.

The pharmaceutical industry relies on surfactants due to their versatile properties, including emulsification, wetting, foaming, and membrane permeability modification. Their incorporation in various formulations enhances the performance, stability, and therapeutic efficacy of pharmaceutical products.

Poloxamer 188 (Surfactants), classified under Additives

Additives in the pharmaceutical API category refer to a group of chemical substances that are incorporated into pharmaceutical products to enhance their stability, functionality, or performance. These additives play a crucial role in ensuring the quality, safety, and efficacy of medications.

One common type of additive used in pharmaceuticals is preservatives. Preservatives are added to prevent microbial growth and maintain the integrity of the product throughout its shelf life. They help to safeguard against contamination and maintain the potency of the active pharmaceutical ingredient (API). Some commonly used preservatives include benzyl alcohol, phenol, and parabens.

Another important group of additives is antioxidants. Antioxidants are added to pharmaceutical formulations to prevent or delay the oxidation of APIs, which can lead to degradation and loss of potency. Examples of antioxidants commonly used in pharmaceuticals include ascorbic acid (vitamin C) and tocopherols (vitamin E).

In addition to preservatives and antioxidants, other additives like flavorings, colorants, and sweeteners may be incorporated into pharmaceutical products to improve their palatability and patient acceptability.

It is crucial to note that the use of additives in pharmaceuticals is strictly regulated by health authorities to ensure their safety and efficacy. Manufacturers must comply with stringent quality control standards and guidelines to guarantee the proper use and appropriate levels of additives in pharmaceutical products.

Overall, additives play a vital role in the pharmaceutical industry by enhancing the stability, functionality, and patient acceptability of medications. Their careful selection and incorporation contribute to the overall quality and effectiveness of pharmaceutical products.