Dexmedetomidine

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API | Excipient name:

Dexmedetomidine 

Synonyms:

Dexmedetomidin , Dexmedetomidina , Dexmedetomidinum  

Cas Number:

113775-47-6 

DrugBank number:

DB00633 

Unique Ingredient Identifier:

67VB76HONO

Dexmedetomidine is a type of Alpha-2 adrenergic agonist

Alpha-2 adrenergic agonists are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) commonly used in the field of medicine. These compounds specifically target and activate alpha-2 adrenergic receptors in the body, which are found primarily in the central nervous system.

Alpha-2 adrenergic agonists exhibit a wide range of pharmacological effects due to their interaction with these receptors. One of their main applications is in the management of hypertension (high blood pressure). By stimulating the alpha-2 adrenergic receptors in the brain, these agonists inhibit the release of norepinephrine, a neurotransmitter that constricts blood vessels. This action leads to vasodilation, resulting in a decrease in blood pressure.

Furthermore, alpha-2 adrenergic agonists are also utilized in ophthalmology to treat conditions such as glaucoma. By reducing the production of aqueous humor, the fluid responsible for intraocular pressure, these compounds help alleviate the symptoms of this eye disorder.

In addition to their cardiovascular and ophthalmological applications, alpha-2 adrenergic agonists have been investigated for their potential role in pain management, sedation, and even in the treatment of attention deficit hyperactivity disorder (ADHD). Research into these areas is ongoing, highlighting the versatility and potential of this API subcategory.

Overall, alpha-2 adrenergic agonists are valuable pharmaceutical compounds that play a crucial role in the treatment of hypertension, glaucoma, and other related disorders. Through their selective interaction with alpha-2 adrenergic receptors, these APIs offer a targeted approach to achieving desired therapeutic outcomes.

Dexmedetomidine (Alpha-2 adrenergic agonist), classified under Antihypertensive agents

Antihypertensive agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat high blood pressure, also known as hypertension. These medications are designed to lower blood pressure and reduce the risk of associated cardiovascular complications.

Antihypertensive agents function by targeting various mechanisms involved in blood pressure regulation. Some common classes of antihypertensive agents include angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta-blockers, calcium channel blockers (CCBs), and diuretics.

ACE inhibitors work by inhibiting the enzyme responsible for converting angiotensin I to angiotensin II, a hormone that constricts blood vessels. ARBs, on the other hand, block the receptors to which angiotensin II binds, thereby preventing its vasoconstrictive effects.

Beta-blockers reduce blood pressure by blocking the effects of adrenaline and noradrenaline, which are responsible for increasing heart rate and constricting blood vessels. CCBs inhibit calcium from entering the smooth muscles of blood vessels, resulting in relaxation and vasodilation. Diuretics promote the elimination of excess fluid and sodium from the body, reducing blood volume and thereby lowering blood pressure.

Antihypertensive agents are typically prescribed based on the individual patient's condition and specific needs. They can be used alone or in combination to achieve optimal blood pressure control. It is important to note that antihypertensive agents should be taken regularly as prescribed by a healthcare professional and may require periodic monitoring to ensure their effectiveness and manage any potential side effects.

In summary, antihypertensive agents play a vital role in the management of hypertension by targeting various mechanisms involved in blood pressure regulation. These medications offer significant benefits in reducing the risk of cardiovascular complications associated with high blood pressure.

• Shandong Chenghui Shuangda Pharmaceutical Co. Ltd. from China
• TIEFENBACHER API + Ingredients from Germany
• J.S.C. Grindeks from Latvia
• Asymchem from China
• Sichuan Benepure from China
• Reliable Biopharm from United States
• Gland Pharma from India
• Norchim from France
• Jiangsu Hengrui from China
• ALCAMI from United States
• Triquim from Argentina
• Moehs from Spain
• Edmond Pharma (Recipharm) from Italy
• Emcure Pharma from India
• Fermion from Finland

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