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Ergosterol | CAS No: 57-87-4 | GMP-certified suppliers
A medication that serves as a provitamin precursor supporting nutritional and bone health, with applications in antifungal research and pharmaceutical development.
Therapeutic categories
Product Snapshot
- Ergosterol is available as an oral tablet formulation
- It is primarily used in therapeutic applications related to fungal infections
- This product is approved or experimental for use in the Canadian market
Clinical Overview
Ergosterol's biological significance is largely associated with its function in fungi and its transformation under ultraviolet radiation. In fungi, ergosterol is a critical component of membrane integrity and fluidity. This property makes its biosynthetic pathway a prominent target for antifungal agents, particularly the azole class of drugs, which inhibit key enzymes involved in ergosterol synthesis, disrupting fungal cell membranes and inhibiting growth.
In animals, ergosterol can be converted via UV light exposure, particularly in the skin, into ergocalciferol (vitamin D2). This photochemical reaction involves the breaking of one of the steroid's bonds, producing a compound important in calcium homeostasis and bone health.
While ergosterol itself is not indicated as a therapeutic agent, it is notable as a provitamin and micronutrient precursor. Its presence and transformation underscore its relevance in dietary and nutritional contexts, as well as in studies related to fungal biology and antifungal drug development.
Pharmacokinetic data and specific mechanism of action beyond its role as a precursor and structural sterol are not well defined. Safety and toxicity profiles are generally considered in the context of its role in biological membranes and as a target of antifungal treatment rather than as an administered drug.
For sourcing and quality considerations relevant to active pharmaceutical ingredient procurement, ergosterol must meet stringent purity criteria due to its use in research, nutritional supplements, and as a reference standard in pharmaceutical development. Control of impurities, including related sterols, and compliance with regulatory standards is essential to ensure batch consistency and reliable performance in downstream applications.
Identification & chemistry
| Generic name | Ergosterol |
|---|---|
| Molecule type | Small molecule |
| CAS | 57-87-4 |
| UNII | Z30RAY509F |
| DrugBank ID | DB04038 |
Formulation & handling
- Ergosterol is a small molecule steroid suitable for oral administration, typically formulated as tablets. Due to its high lipophilicity (LogP 6.63), formulation approaches should consider solubility enhancement to improve bioavailability. The compound's low aqueous solubility necessitates careful handling to ensure consistent dosing and stability in solid dosage forms.
Regulatory status
| Lifecycle | The API's primary patent protection in Canada has expired, allowing for generic entries and increased market competition. The product is currently marketed in Canada, reflecting a mature market stage. |
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| Markets | Canada |
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Supply Chain
| Supply chain summary | The manufacturing and supply landscape for Ergosterol includes originator companies producing branded products primarily available in the Canadian market. The presence of branded samples such as Zoo Chews Plus Iron suggests established formulations targeting specific uses. Patent expiry information is not provided, so the extent of current or upcoming generic competition cannot be determined. |
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Ergosterol is a type of Antifungals
Antifungals are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) designed to combat fungal infections. These medications are developed to target and eliminate fungi, including yeasts and molds, which can cause a range of diseases in humans and animals.
Antifungals work by interfering with specific components or processes essential for fungal growth and reproduction. They may inhibit the synthesis of fungal cell walls or disrupt the production of ergosterol, a crucial component of fungal cell membranes. By targeting these key mechanisms, antifungal APIs effectively hinder the growth and spread of fungal infections.
The diversity within the antifungal category is reflected in the various classes of antifungal APIs available. Azoles, polyenes, echinocandins, and allylamines are common classes of antifungals. Each class exhibits unique mechanisms of action and targets specific types of fungi. This diversity enables healthcare professionals to tailor treatment plans to the specific fungal infection, optimizing therapeutic outcomes.
Antifungal APIs find application in various pharmaceutical formulations, including oral medications, topical creams, ointments, and intravenous solutions. They are crucial for the treatment of common fungal infections like athlete's foot, ringworm, vaginal yeast infections, and oral thrush. Additionally, antifungals play a crucial role in managing serious systemic fungal infections that can pose significant health risks, especially in immunocompromised individuals.
Overall, antifungal APIs are indispensable tools in the fight against fungal infections, offering effective treatment options and improving the quality of life for patients suffering from these conditions. With ongoing research and development, the antifungal category continues to evolve, providing innovative solutions to combat the ever-changing landscape of fungal pathogens.
Ergosterol API manufacturers & distributors
Compare qualified Ergosterol API suppliers worldwide. We currently have 2 companies offering Ergosterol API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Changzhou Comwin Fine Che... | Producer | China | China | CoA | 235 products |
| Sichuan Neijiang Huixin P... | Producer | China | China | CoA | 3 products |
When sending a request, specify which Ergosterol API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Ergosterol API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
