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Selenium Sulfide API Manufacturers & Suppliers

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Commercial-scale Suppliers

United States

Distributor
Produced in  World
|

Employees: 200+

|
Audit Report: Currently Eurofins has no report for this supplier. Contact them to let them know you're interested!
Certifications: GMP
|
CEP
|
USDMF
|
MSDS
|
BSE/TSE

All certificates

GMP
CEP
USDMF
MSDS
BSE/TSE
CoA
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India

Producer
Produced in  India
|
Audit Report: Currently Eurofins has no report for this supplier. Contact them to let them know you're interested!
Certifications: USDMF
|
CoA

All certificates

USDMF
CoA
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Selenium Sulfide | CAS No: 7488-56-4 | GMP-certified suppliers

A medication that supports topical management of tinea versicolor, tinea capitis, dandruff, and seborrheic dermatitis for reliable dermatological API sourcing.

Therapeutic categories

Antifungals for Dermatological UseAntifungals for Topical UseDermatologicalsSelenium Compounds
Generic name
Selenium Sulfide
Molecule type
small molecule
CAS number
7488-56-4
DrugBank ID
DB00971
Approval status
Approved drug
ATC code
D01AE13

Primary indications

  • For treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp

Product Snapshot

  • Topical dermatologic preparations supplied as shampoos, lotions, suspensions, foams, and other liquid vehicles
  • Used for management of tinea versicolor, tinea capitis, dandruff, and seborrheic dermatitis
  • Approved in the US and Canada for topical use

Clinical Overview

Selenium sulfide (CAS 7488-56-4) is an inorganic non‑metal sulfide used topically for the management of tinea versicolor, tinea capitis, dandruff, and seborrheic dermatitis. Its primary clinical applications involve conditions characterized by excess colonization with Malassezia species or accelerated epidermal turnover. Formulations are typically delivered as shampoos, suspensions, or lotions for scalp and skin use.

Pharmacologically, selenium sulfide functions as both an antifungal and a cytostatic agent. It demonstrates pronounced activity against Malassezia furfur and other organisms associated with superficial mycoses, including Microsporum species and Trichophyton species. Activity has also been documented against Pityrosporon species. A micronized 0.6 percent form has been shown to be effective for dandruff in clinical use contexts. Its sporicidal effect on Trichophyton tonsurans supports its role in adjunctive management of tinea capitis, particularly in pediatric populations.

The mechanism of action is primarily antimitotic. Selenium sulfide reduces epidermal cell turnover by decreasing thymidine incorporation into DNA of dermal epithelial cells. This reduction in proliferation helps normalize scaling and flaking associated with seborrheic dermatitis and dandruff. Additional local irritant, mild antibacterial, and antifungal effects may contribute to overall clinical benefit, especially in polymicrobial scalp conditions.

Systemic absorption following topical use is generally low when applied as directed and rinsed off after short contact periods. Therefore, pharmacokinetic parameters such as distribution, metabolism, and elimination are not well defined. Safety considerations mainly involve local effects, including irritation, oiliness or dryness of hair and scalp, and potential discoloration of hair or certain cosmetic treatments. Prolonged contact with skin or occlusive application can increase irritation risk.

Common usage contexts include medicated shampoos and dermatological preparations marketed in multiple regions. For API procurement, sourcing should focus on material identity, particle size control, and impurity profiling appropriate for topical formulations, with compliance to regional pharmacopeial or quality standards.

Identification & chemistry

Generic name Selenium Sulfide
Molecule type Small molecule
CAS 7488-56-4
UNII Z69D9E381Q
DrugBank ID DB00971

Pharmacology

SummarySelenium sulfide reduces epidermal cell turnover through antimitotic activity and exerts local antifungal, antibacterial, and irritant effects. It targets organisms such as Malassezia and various dermatophytes, including sporicidal action against Trichophyton species. These pharmacologic actions support its use in scalp and skin conditions characterized by fungal overgrowth and hyperproliferation.
Mechanism of actionTopical selenium sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that selenium sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to selenium sulfide in vitro: <i>Malassezia furfur</i>, <i>Microsporum sp.</i> including <i>Microsporum audouinii</i> and <i>Microsporum canis</i>, <i>Pityrosporon sp.</i>, <i>Trichophyton sp.</i> including <i>Trichophyton schoenleinii</i> and <i>Trichophyton tonsurans</i>. Selenium sulfide has been shown to be sporicidal to <i>T. tonsurans</i>, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% selenium sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione.
PharmacodynamicsSelenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of <i>P. ovale</i>. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff.

ADME / PK

AbsorptionThere is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 &mu;g/ml in her urine.

Formulation & handling

  • Topical-only inorganic solid typically formulated as suspensions or dispersions due to poor aqueous solubility, requiring surfactants and particle-size control for uniformity.
  • Suspension-based shampoos and lotions may need rheology modifiers to prevent settling and ensure even delivery during use.
  • Material can discolor and may be sensitive to oxidation or pH shifts, so formulations generally use stabilizing excipients and protected packaging.

Regulatory status

LifecyclePatent‑expiry information was not provided, so only a location‑based assessment can be offered. With products marketed in the US and Canada, the API is positioned in two mature, highly regulated markets, suggesting a late‑stage or post‑patent‑expiry lifecycle unless protected by additional exclusivities.
MarketsUS, Canada
Supply Chain
Supply chain summaryThe supply landscape for selenium sulfide includes an originator group with multiple established pharmaceutical manufacturers, supported by a broad network of U.S. and Canadian packagers. Branded products appear primarily in North American markets, with no clear indicators of wider EU commercialization. Patent expiry for this mature active ingredient suggests that generic competition is already well established.

Safety

ToxicityNo documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity.
High Level Warnings:
  • Acute toxicity studies in animals indicate systemic toxicity at high oral doses
  • While serious human cases are undocumented, large‑quantity ingestion is considered a potential hazard
  • Selenium sulfide can cause irritation to skin, eyes, and respiratory pathways upon direct contact or aerosolization

Selenium Sulfide is a type of Antimycotics


Antimycotics, a subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs), are essential in the treatment of various fungal infections. These powerful medications target and eliminate harmful fungi that can cause infections in humans.

Antimycotics are classified into two main types: systemic and topical. Systemic antimycotics are administered orally or intravenously and work by circulating throughout the body, treating systemic fungal infections that affect internal organs or spread throughout the bloodstream. On the other hand, topical antimycotics are applied externally to treat localized fungal infections such as athlete's foot or yeast infections.

The efficacy of antimycotics lies in their ability to disrupt fungal cell membranes, inhibit the synthesis of fungal DNA or proteins, or interfere with essential metabolic processes specific to fungi. This targeted action minimizes damage to human cells, making these medications relatively safe for patients.

Commonly prescribed antimycotics include azoles, polyenes, allylamines, and echinocandins. Azoles inhibit the synthesis of ergosterol, a vital component of fungal cell membranes, while polyenes bind to ergosterol, resulting in the formation of pores that lead to cell death. Allylamines disrupt the synthesis of ergosterol and inhibit the activity of squalene epoxidase, an enzyme involved in ergosterol production. Echinocandins target the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall.

Antimycotics play a crucial role in the management of fungal infections, offering relief to patients and aiding in their recovery. As with any medication, it is important to follow healthcare professionals' guidance regarding dosage, duration of treatment, and potential side effects to ensure optimal therapeutic outcomes.


Selenium Sulfide (Antimycotics), classified under Antifungals


Antifungals are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) designed to combat fungal infections. These medications are developed to target and eliminate fungi, including yeasts and molds, which can cause a range of diseases in humans and animals.

Antifungals work by interfering with specific components or processes essential for fungal growth and reproduction. They may inhibit the synthesis of fungal cell walls or disrupt the production of ergosterol, a crucial component of fungal cell membranes. By targeting these key mechanisms, antifungal APIs effectively hinder the growth and spread of fungal infections.

The diversity within the antifungal category is reflected in the various classes of antifungal APIs available. Azoles, polyenes, echinocandins, and allylamines are common classes of antifungals. Each class exhibits unique mechanisms of action and targets specific types of fungi. This diversity enables healthcare professionals to tailor treatment plans to the specific fungal infection, optimizing therapeutic outcomes.

Antifungal APIs find application in various pharmaceutical formulations, including oral medications, topical creams, ointments, and intravenous solutions. They are crucial for the treatment of common fungal infections like athlete's foot, ringworm, vaginal yeast infections, and oral thrush. Additionally, antifungals play a crucial role in managing serious systemic fungal infections that can pose significant health risks, especially in immunocompromised individuals.

Overall, antifungal APIs are indispensable tools in the fight against fungal infections, offering effective treatment options and improving the quality of life for patients suffering from these conditions. With ongoing research and development, the antifungal category continues to evolve, providing innovative solutions to combat the ever-changing landscape of fungal pathogens.



Selenium Sulfide API manufacturers & distributors

Compare qualified Selenium Sulfide API suppliers worldwide. We currently have 2 companies offering Selenium Sulfide API, with manufacturing taking place in 2 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.

SupplierTypeCountryProduct originCertificationsPortfolio
Distributor
United States World BSE/TSE, CEP, CoA, GMP, MSDS, USDMF441 products
Producer
India India CoA, USDMF1 products

When sending a request, specify which Selenium Sulfide API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).

Use the list above to find high-quality Selenium Sulfide API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.

We show synonyms and CAS numbers for Selenium Sulfide API to help you connect with the right supplier. However, a synonym or CAS number does not always mean it is exactly the same specification. Always confirm the final specs directly with the supplier before placing an order.

Frequently asked questions about Selenium Sulfide API


Sourcing

What matters most when sourcing GMP-grade Selenium Sulfide?
When sourcing GMP-grade Selenium Sulfide, the key factors are compliance with U.S. and Canadian regulatory requirements and verification that the manufacturer operates under established GMP standards. It is also important to confirm that the supplier is part of the well‑established originator or generic manufacturing base and that packaging partners meet applicable North American quality expectations. Ensuring traceability across this supply chain supports consistent quality and regulatory alignment.
Which documents are typically required when sourcing Selenium Sulfide API?
Request the core API documentation set: CoA (3 companies), USDMF (2 companies), MSDS (2 companies), ISO9001 (1 company), CEP (1 company). Confirm versions and validity dates match the destination market to avoid delays in qualification.
Which manufacturers are known to produce Selenium Sulfide API?
Known or reported manufacturers for Selenium Sulfide: Xi'an Tian Guangyuan Biotech Co.,Ltd, LGM Pharma. Evaluate their GMP history, scale, and regional coverage before requesting dossiers or allocating demand.
How can I request quotes for Selenium Sulfide API from GMP suppliers?
Submit quote requests through the supplier listings with your specs and required documents (specifications, target volume, delivery timeline, and destination). Providing consistent details upfront speeds comparable offers and clarifies technical feasibility.
Is a GMP audit report available for Selenium Sulfide manufacturers?
Audit reports may be requested for Selenium Sulfide: 0 GMP audit reports available. Confirm the scope and recency of any audit before relying on it for qualification decisions.
How many suppliers offer Selenium Sulfide API on Pharmaoffer?
Reported supplier count for Selenium Sulfide: 3 verified suppliers. Filter listings by certifications, regions, and delivery options to match your qualification plan.
Which countries are known to manufacture Selenium Sulfide API?
Production countries reported for Selenium Sulfide: China (1 producer), India (1 producer). Knowing the manufacturing geography helps anticipate logistics lead times and import compliance needs.
Which certifications do suppliers of Selenium Sulfide usually hold?
Common certifications for Selenium Sulfide suppliers: CoA (3 companies), USDMF (2 companies), MSDS (2 companies), ISO9001 (1 company), CEP (1 company). Always verify issuing authorities and expiry dates when reviewing audit packages.

Technical

What is Selenium Sulfide (CAS 7488-56-4) used for?
Selenium Sulfide is used topically to manage dandruff, seborrheic dermatitis, tinea versicolor, and as an adjunct in tinea capitis. It provides antifungal and cytostatic effects that reduce Malassezia colonization and slow excessive epidermal turnover. Typical formulations include shampoos, suspensions, and lotions for scalp and skin application.
Which therapeutic class does Selenium Sulfide fall into?
Selenium Sulfide belongs to the following therapeutic categories: Antifungals for Dermatological Use, Antifungals for Topical Use, Dermatologicals, Selenium Compounds. This positioning helps teams compare alternative APIs, anticipate pharmacology expectations, and align early research priorities.
What conditions is Selenium Sulfide mainly prescribed for?
The primary indications for Selenium Sulfide: For treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp. These use cases frame the target patient populations and help prioritize formulation and safety evaluations.
How does Selenium Sulfide work?
Topical Selenium Sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that Selenium Sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to Selenium Sulfide in vitro: Malassezia furfur, Microsporum sp. including Microsporum audouinii and Microsporum canis, Pityrosporon sp., Trichophyton sp. including Trichophyton schoenleinii and Trichophyton tonsurans. Selenium Sulfide has been shown to be sporicidal to T. tonsurans, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% Selenium Sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione.
What should someone know about the safety or toxicity profile of Selenium Sulfide?
Selenium Sulfide is primarily associated with local irritation, including redness, stinging, or dryness of the skin or scalp, and it may discolor hair or cosmetic treatments. Systemic absorption from topical use is generally low, but prolonged or occlusive contact can increase irritation risk. It can irritate the eyes, skin, or respiratory tract if directly contacted or aerosolized. Large oral doses have caused systemic toxicity in animal studies, and ingestion of substantial amounts is considered hazardous.
What are important formulation and handling considerations for Selenium Sulfide as an API?
Selenium Sulfide is formulated only for topical use and is typically dispersed as a suspension because of its poor aqueous solubility, requiring surfactants and particle‑size control for uniformity. Suspension shampoos or lotions often include rheology modifiers to prevent settling and ensure consistent dosing. The material can discolor and may be sensitive to oxidation or pH shifts, so stabilizers and protective packaging are commonly used. Systemic absorption is minimal through intact skin, but higher absorption can occur over open lesions, which should be considered during product design and handling.
Is Selenium Sulfide a small molecule?
Selenium Sulfide is classified as a small molecule. That classification shapes process design, impurity profiling, and analytical control strategies.
Are there special stability concerns for oral Selenium Sulfide?
Selenium Sulfide is formulated as a topical‐only inorganic solid, so stability considerations apply to suspended topical products rather than oral preparations. It has poor aqueous solubility, tends to settle without rheology control, and can discolor or degrade with oxidation or pH shifts. Stabilizing excipients and protective packaging are typically used to maintain stability in these topical formulations.

Regulatory

Where is Selenium Sulfide approved or in use globally?
Selenium Sulfide is reported as approved in the following major regions: US, Canada. Understanding geographic coverage informs regulatory filings, supply planning, and risk assessments before escalating procurement.
What’s the regulatory and patent landscape for Selenium Sulfide right now?
Selenium Sulfide is regulated in the United States and Canada as an active ingredient in over‑the‑counter products for dandruff and related scalp conditions. Its use is defined by each country’s OTC monograph or equivalent regulatory framework governing such topical formulations.

Pharmaoffer

How does Pharmaoffer’s Smart Sourcing Service help with Selenium Sulfide procurement?
Pharmaoffer's Smart Sourcing Service coordinates compliant suppliers, documentation, and competitive quotes for Selenium Sulfide. It centralizes outreach, follow-ups, and document validation to shorten procurement timelines.
Is Selenium Sulfide included in the PRO Data Insights coverage?
PRO Data Insights coverage for Selenium Sulfide: 8 verified transactions across 7 suppliers and 7 buyers worldwide. Use the dataset to benchmark suppliers and monitor regulatory activity where available.
Where can I access the API market report for Selenium Sulfide?
Market report availability for Selenium Sulfide: Report Available. The report highlights demand trends, pricing drivers, and supplier landscape insights for procurement planning.