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Acotiamide API Manufacturers & Suppliers
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Acotiamide | CAS No: 185106-16-5 | GMP-certified suppliers
A medication that improves gastric motility and alleviates symptoms in functional dyspepsia and other functional gastrointestinal disorders.
Therapeutic categories
Product Snapshot
- Acotiamide is an oral small molecule formulation available as a tablet
- The compound is primarily investigated for gastrointestinal motility disorders
- It currently holds investigational status and is not yet approved by key regulatory agencies
Clinical Overview
Clinically, acotiamide has been investigated predominantly for its role in treating dyspepsia and functional dyspepsia. These conditions are characterized by upper gastrointestinal symptoms without identifiable organic causes. Although the specific clinical indication for acotiamide has not been globally established, investigative studies have focused on its potential to improve gastric motility and symptom relief in functional gastrointestinal disorders.
Pharmacodynamically, acotiamide acts as a cholinesterase inhibitor, thereby enhancing cholinergic neurotransmission in the gastrointestinal tract. By inhibiting acetylcholinesterase enzymes, it increases acetylcholine levels, which may contribute to gastroprokinetic effects and improved gastric emptying, though detailed mechanistic insights remain under clinical evaluation.
Absorption, distribution, metabolism, and excretion (ADME) parameters for acotiamide are not comprehensively described in available data. However, as an orally administered compound under investigation, its bioavailability and metabolic pathways require careful consideration in formulation development and pharmacokinetic assessments.
Safety and toxicity profiles for acotiamide have not been fully characterized in large-scale clinical studies. As an investigational agent, its tolerability and adverse effect spectrum necessitate ongoing evaluation to establish a thorough risk-benefit framework.
Currently, acotiamide remains in the investigational category without widespread regulatory approval. Notable product development involves its use as a prokinetic agent targeting functional gastrointestinal symptoms.
From an API procurement perspective, the sourcing of acotiamide requires adherence to stringent quality standards given its investigational nature. Suppliers should provide comprehensive documentation including Certificates of Analysis, impurity profiles, and compliance with relevant pharmacopeial specifications. Stability data and batch-to-batch consistency are critical parameters to ensure reproducible performance in clinical or formulation research settings.
Identification & chemistry
| Generic name | Acotiamide |
|---|---|
| Molecule type | Small molecule |
| CAS | 185106-16-5 |
| UNII | D42OWK5383 |
| DrugBank ID | DB12482 |
Formulation & handling
- Acotiamide is a small molecule compound formulated for oral administration as a tablet.
- It exhibits low water solubility, which may affect dissolution and bioavailability in formulation.
- No peptide or biologic properties are present; standard handling precautions for small molecules apply.
Regulatory status
Acotiamide is a type of Enzyme Replacements/modifiers
Enzyme replacements/modifiers are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various enzyme-related disorders. Enzymes play a vital role in the normal functioning of the body by catalyzing specific biochemical reactions. However, in certain medical conditions, the body may lack or produce dysfunctional enzymes, leading to serious health complications.
Enzyme replacement therapy (ERT) involves administering exogenous enzymes to compensate for the enzyme deficiency in patients. These enzymes are typically derived from natural sources or produced using recombinant DNA technology. By introducing these enzymes into the body, they can effectively substitute the missing or defective enzymes, thereby restoring normal metabolic processes.
On the other hand, enzyme modifiers are API substances that regulate the activity of specific enzymes within the body. These modifiers can either enhance or inhibit the enzyme's function, depending on the therapeutic objective. By modulating enzyme activity, these APIs can restore the balance of enzymatic reactions, leading to improved physiological outcomes.
Enzyme replacements/modifiers have shown remarkable success in treating various genetic disorders, such as Gaucher disease, Fabry disease, and lysosomal storage disorders. Additionally, they have demonstrated potential in managing enzyme deficiencies associated with rare diseases and certain types of cancer.
The development and production of enzyme replacements/modifiers involve rigorous research, formulation optimization, and adherence to stringent quality control measures. Pharmaceutical companies invest substantial resources in developing these APIs to ensure their safety, efficacy, and compliance with regulatory standards.
Overall, enzyme replacements/modifiers represent a vital therapeutic category in modern medicine, offering hope and improved quality of life for patients with enzyme-related disorders.
Acotiamide API manufacturers & distributors
Compare qualified Acotiamide API suppliers worldwide. We currently have 1 companies offering Acotiamide API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Global Pharma Tek | Distributor | India | India | BSE/TSE, CoA, FDA, GMP, ISO9001, MSDS | 484 products |
When sending a request, specify which Acotiamide API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Acotiamide API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
