Enzyme Replacements/modifiers

Enzyme replacements/modifiers are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various enzyme-related disorders. Enzymes play a vital role in the normal functioning of the body by catalyzing specific biochemical reactions. However, in certain medical conditions, the body may lack or produce dysfunctional enzymes, leading to serious health complications.

Enzyme replacement therapy (ERT) involves administering exogenous enzymes to compensate for the enzyme deficiency in patients. These enzymes are typically derived from natural sources or produced using recombinant DNA technology. By introducing these enzymes into the body, they can effectively substitute the missing or defective enzymes, thereby restoring normal metabolic processes.

On the other hand, enzyme modifiers are API substances that regulate the activity of specific enzymes within the body. These modifiers can either enhance or inhibit the enzyme's function, depending on the therapeutic objective. By modulating enzyme activity, these APIs can restore the balance of enzymatic reactions, leading to improved physiological outcomes.

Enzyme replacements/modifiers have shown remarkable success in treating various genetic disorders, such as Gaucher disease, Fabry disease, and lysosomal storage disorders. Additionally, they have demonstrated potential in managing enzyme deficiencies associated with rare diseases and certain types of cancer.

The development and production of enzyme replacements/modifiers involve rigorous research, formulation optimization, and adherence to stringent quality control measures. Pharmaceutical companies invest substantial resources in developing these APIs to ensure their safety, efficacy, and compliance with regulatory standards.

Overall, enzyme replacements/modifiers represent a vital therapeutic category in modern medicine, offering hope and improved quality of life for patients with enzyme-related disorders.

Name	CAS number	Category	Amount of suppliers
Abexinostat	783355-60-2	Enzyme Replacements/modifiers	0
Abivertinib	1557267-42-1	Enzyme Replacements/modifiers	0
Acifluorfen	50594-66-6	Enzyme Replacements/modifiers	0
Acotiamide	185106-16-5	Enzyme Replacements/modifiers	0
Acridine Carboxamide	89459-25-6	Enzyme Replacements/modifiers	0
Acrizanib	1229453-99-9	Enzyme Replacements/modifiers	0
Acumapimod	836683-15-9	Enzyme Replacements/modifiers	0
Alflutinib	1869057-83-9	Enzyme Replacements/modifiers	0
Alpelisib	1217486-61-7	Enzyme Replacements/modifiers	0
Aminooxyacetic acid	645-88-5	Enzyme Replacements/modifiers	0
Anagliptin	739366-20-2	Enzyme Replacements/modifiers	0
Arachidonyltrifluoromethane	149301-79-1	Enzyme Replacements/modifiers	0
Ataciguat	254877-67-3	Enzyme Replacements/modifiers	0
Atreleuton	154355-76-7	Enzyme Replacements/modifiers	0
Avacopan	1346623-17-3	Enzyme Replacements/modifiers	1
Avagacestat	1146699-66-2	Enzyme Replacements/modifiers	0
Avapritinib	1703793-34-3	Enzyme Replacements/modifiers	0
Avasimibe	166518-60-1	Enzyme Replacements/modifiers	0
Avidin	110539-97-4	Enzyme Replacements/modifiers	0
Bafetinib	859212-16-1	Enzyme Replacements/modifiers	0
Basifungin	127785-64-2	Enzyme Replacements/modifiers	0
Begacestat	769169-27-9	Enzyme Replacements/modifiers	0
Belotecan	256411-32-2	Enzyme Replacements/modifiers	0
Benazeprilat	86541-78-8	Enzyme Replacements/modifiers	0
Bisindolylmaleimide I	133052-90-1	Enzyme Replacements/modifiers	0
Bisindolylmaleimide VIII	125313-65-7	Enzyme Replacements/modifiers	0
Branebrutinib	1912445-55-6	Enzyme Replacements/modifiers	0
Bromopyruvate	1113-59-3	Enzyme Replacements/modifiers	0
Buthionine sulfoximine	5072-26-4	Enzyme Replacements/modifiers	0
Butyrylcholinesterase	9001-08-5	Enzyme Replacements/modifiers	0
CP-320626	186430-23-9	Enzyme Replacements/modifiers	0
Camostat	59721-28-7	Enzyme Replacements/modifiers	1
Candoxatrilat	123122-54-3	Enzyme Replacements/modifiers	0
Capmatinib	1029712-80-8	Enzyme Replacements/modifiers	0
Carbaryl	63-25-2	Enzyme Replacements/modifiers	0
Cediranib	288383-20-0	Enzyme Replacements/modifiers	0
Cepeginterferon alfa-2B	1192706-52-7	Enzyme Replacements/modifiers	0
Chymostatin	9076-44-2	Enzyme Replacements/modifiers	0
Cilazaprilat	90139-06-3	Enzyme Replacements/modifiers	0
Ciluprevir	300832-84-2	Enzyme Replacements/modifiers	0
Coenzyme A	85-61-0	Enzyme Replacements/modifiers	0
Collagenase clostridium histolyticum	9001-12-1	Enzyme Replacements/modifiers	1
Coltuximab ravtansine	1269764-99-9	Enzyme Replacements/modifiers	0
D-4-hydroxyphenylglycine	22818-40-2	Enzyme Replacements/modifiers	0
Daglutril	182821-27-8	Enzyme Replacements/modifiers	0
Danoprevir	850876-88-9	Enzyme Replacements/modifiers	0
Darapladib	356057-34-6	Enzyme Replacements/modifiers	0
Darexaban	365462-23-3	Enzyme Replacements/modifiers	0
Delanzomib	847499-27-8	Enzyme Replacements/modifiers	0
Delapril	83435-66-9	Enzyme Replacements/modifiers	0
Deslorelin	57773-65-6	Enzyme Replacements/modifiers	0
Dichlororibofuranosylbenzimidazole	53-85-0	Enzyme Replacements/modifiers	0
Difloxacin	98106-17-3	Enzyme Replacements/modifiers	0
Diphenyleneiodonium	244-54-2	Enzyme Replacements/modifiers	0
Dipicolinic acid	499-83-2	Enzyme Replacements/modifiers	0
Dornase alfa	143831-71-4	Other enzyme replacements/modifiers	4
Dorsomorphin	866405-64-3	Enzyme Replacements/modifiers	0
Edetate calcium disodium anhydrous	62-33-9	Enzyme Replacements/modifiers	0
Edetate disodium anhydrous	139-33-3	Enzyme Replacements/modifiers	0
Elapegademase	1709806-75-6	Enzyme Replacements/modifiers	0
Eliglustat	491833-29-5	Other enzyme replacements/modifiers	8
Emodin	518-82-1	Enzyme Replacements/modifiers	0
Ensartinib	1370651-20-9	Enzyme Replacements/modifiers	0
Entinostat	209783-80-2	Enzyme Replacements/modifiers	0
Epicaptopril	63250-36-2	Enzyme Replacements/modifiers	0
Farudodstat	1035688-66-4	Enzyme Replacements/modifiers	0
Fedratinib	936091-26-8	Enzyme Replacements/modifiers	0
Fenthion	55-38-9	Enzyme Replacements/modifiers	0
Firsocostat	1434635-54-7	Enzyme Replacements/modifiers	0
Flavin adenine dinucleotide	146-14-5	Enzyme Replacements/modifiers	0
Flumatinib	895519-90-1	Enzyme Replacements/modifiers	0
Flumecinol	56430-99-0	Enzyme Replacements/modifiers	0
Folitixorin	3432-99-3	Enzyme Replacements/modifiers	0
Fosinoprilat	95399-71-6	Enzyme Replacements/modifiers	0
Fulacimstat	1488354-15-9	Enzyme Replacements/modifiers	0
Gedatolisib	1197160-78-3	Enzyme Replacements/modifiers	0
Hemicellulase	9025-56-3	Enzyme Replacements/modifiers	0
Huperzine B	103548-82-9	Enzyme Replacements/modifiers	0
Hyaluronidase	488712-31-8	Enzyme Replacements/modifiers	4
Ibrexafungerp	1207753-03-4	Enzyme Replacements/modifiers	0
Ilomastat	142880-36-2	Enzyme Replacements/modifiers	0
Imetelstat	868169-64-6	Enzyme Replacements/modifiers	0
Imidapril	89371-37-9	Enzyme Replacements/modifiers	0
Imidazole	288-32-4	Enzyme Replacements/modifiers	0
Ipatasertib	1001264-89-6	Enzyme Replacements/modifiers	0
Isoliquiritigenin	961-29-5	Enzyme Replacements/modifiers	0
Itanapraced	749269-83-8	Enzyme Replacements/modifiers	0
Ivacaftor	873054-44-5	CFTR regulator	5
Ivosidenib	1448347-49-6	Enzyme Replacements/modifiers	0
Lanopepden	1152107-25-9	Enzyme Replacements/modifiers	0
Lavendustin A	125697-92-9	Enzyme Replacements/modifiers	0
Lazertinib	1903008-80-9	Enzyme Replacements/modifiers	0
Leupeptin	55123-66-5	Enzyme Replacements/modifiers	0
Levoketoconazole	142128-57-2	Enzyme Replacements/modifiers	1
Linrodostat	1923833-60-6	Enzyme Replacements/modifiers	0
Lometrexol	106400-81-1	Enzyme Replacements/modifiers	0
Lorlatinib	1454846-35-5	Enzyme Replacements/modifiers	0
Lorvotuzumab mertansine	1008106-64-6	Enzyme Replacements/modifiers	0
Lumacaftor	936727-05-8	CFTR regulator	1
Lumichrome	1086-80-2	Enzyme Replacements/modifiers	0
Lumiflavin	1088-56-8	Enzyme Replacements/modifiers	0
Manitimus	202057-76-9	Enzyme Replacements/modifiers	0
Melagatran	159776-70-2	Enzyme Replacements/modifiers	0
Methanesulfonyl Fluoride	558-25-8	Enzyme Replacements/modifiers	0
Mirodenafil	862189-95-5	Enzyme Replacements/modifiers	0
Mitemcinal	154738-42-8	Enzyme Replacements/modifiers	0
Mocetinostat	726169-73-9	Enzyme Replacements/modifiers	0
Moexiprilat	103775-14-0	Enzyme Replacements/modifiers	0
Molybdenum	7439-98-7	Enzyme Replacements/modifiers	0
Molybdenum cofactor	872689-63-9	Enzyme Replacements/modifiers	0
Momelotinib	1056634-68-4	Enzyme Replacements/modifiers	0
Motesanib	453562-69-1	Enzyme Replacements/modifiers	0
Mucopolysaccharidase		Enzyme Replacements/modifiers	1
N(G)-Iminoethylornithine	36889-13-1	Enzyme Replacements/modifiers	0
N-omega-nitro-L-arginine methyl ester	50903-99-6	Enzyme Replacements/modifiers	0
NADPH	53-57-6	Enzyme Replacements/modifiers	0
Nadide	53-84-9	Enzyme Replacements/modifiers	0
Naquotinib	1448232-80-1	Enzyme Replacements/modifiers	0
Nattokinase	133876-92-3	Enzyme Replacements/modifiers	0
Nedisertib	1637542-33-6	Enzyme Replacements/modifiers	0
Nedosiran	2266591-83-5	Enzyme Replacements/modifiers	0
Nemiralisib	1254036-71-9	Enzyme Replacements/modifiers	0
Nemonoxacin	378746-64-6	Enzyme Replacements/modifiers	0
Neopterin	2009-64-5	Enzyme Replacements/modifiers	0
Nicotinamide adenine dinucleotide phosphate	53-59-8	Enzyme Replacements/modifiers	0
Nikkomycin Z	59456-70-1	Enzyme Replacements/modifiers	0
Nirogacestat	1290543-63-3	Enzyme Replacements/modifiers	0
Obatoclax	803712-67-6	Enzyme Replacements/modifiers	0
Onvansertib	1034616-18-6	Enzyme Replacements/modifiers	0
Otamixaban	193153-04-7	Enzyme Replacements/modifiers	0
Oxetacaine	126-27-2	Enzyme Replacements/modifiers	0
Ozagrel	82571-53-7	Enzyme Replacements/modifiers	0
PD-169316	152121-53-4	Enzyme Replacements/modifiers	0
Pacritinib	937272-79-2	Enzyme Replacements/modifiers	0
Pancrelipase	53608-75-6	Pancreatic enzymes	1
Paxalisib	1382979-44-3	Enzyme Replacements/modifiers	0
Peficitinib	944118-01-8	Enzyme Replacements/modifiers	0
Pegvorhyaluronidase alfa	1620390-06-8	Enzyme Replacements/modifiers	0
Perindoprilat	95153-31-4	Enzyme Replacements/modifiers	0
Petesicatib	1252637-35-6	Enzyme Replacements/modifiers	0
Pevonedistat	905579-51-3	Enzyme Replacements/modifiers	0
Pexidartinib	1029044-16-3	Enzyme Replacements/modifiers	0
Picric acid	88-89-1	Enzyme Replacements/modifiers	0
Pipemidic acid	51940-44-4	Enzyme Replacements/modifiers	0
Piperine	94-62-2	Enzyme Replacements/modifiers	1
Posiphen	116839-68-0	Enzyme Replacements/modifiers	0
Pralsetinib	2097132-94-8	Enzyme Replacements/modifiers	0
Prexasertib	1234015-52-1	Enzyme Replacements/modifiers	0
Prulifloxacin	123447-62-1	Enzyme Replacements/modifiers	0
Queuine	72496-59-4	Enzyme Replacements/modifiers	0
Quinaprilat	82768-85-2	Enzyme Replacements/modifiers	0
Quinonoid 7,8-Tetrahydrobiopterin	79647-29-3	Enzyme Replacements/modifiers	0
Racemetyrosine	658-48-0	Enzyme Replacements/modifiers	0
Ramiprilat	87269-97-4	Enzyme Replacements/modifiers	0
Ravoxertinib	1453848-26-4	Enzyme Replacements/modifiers	0
Relebactam	1174018-99-5	Enzyme Replacements/modifiers	0
Riboflavin tetrabutyrate	752-56-7	Enzyme Replacements/modifiers	0
Ridaforolimus	572924-54-0	Enzyme Replacements/modifiers	0
Rigosertib	592542-59-1	Enzyme Replacements/modifiers	0
Rimacalib	215174-50-8	Enzyme Replacements/modifiers	0
Rivoceranib	811803-05-1	Enzyme Replacements/modifiers	0
Ronopterin	185243-78-1	Enzyme Replacements/modifiers	0
Ropeginterferon alfa-2b	1335098-50-4	Enzyme Replacements/modifiers	0
Ruboxistaurin	169939-94-0	Enzyme Replacements/modifiers	0
Rucaparib	283173-50-2	Enzyme Replacements/modifiers	1
S-Hexylglutathione	24425-56-7	Enzyme Replacements/modifiers	0
Safinamide	133865-89-1	Enzyme Replacements/modifiers	0
Safingol	15639-50-6	Enzyme Replacements/modifiers	0
Sarilumab	1189541-98-7	Enzyme Replacements/modifiers	0
Selonsertib	1448428-04-3	Enzyme Replacements/modifiers	0
Selpercatinib	2152628-33-4	Enzyme Replacements/modifiers	0
Semagacestat	425386-60-3	Enzyme Replacements/modifiers	0
Serabelisib	1268454-23-4	Enzyme Replacements/modifiers	0
Sivelestat	127373-66-4	Enzyme Replacements/modifiers	0
Somapacitan	1338578-34-9	Enzyme Replacements/modifiers	0
Spebrutinib	1202757-89-8	Enzyme Replacements/modifiers	0
Stem bromelain	37189-34-7	Enzyme Replacements/modifiers	0
Subasumstat	1858276-04-6	Enzyme Replacements/modifiers	0
Tacedinaline	112522-64-2	Enzyme Replacements/modifiers	0
Talarozole	201410-53-9	Enzyme Replacements/modifiers	0
Telotristat ethyl	1033805-22-9	Enzyme Replacements/modifiers	0
Tenalisib	1639417-53-0	Enzyme Replacements/modifiers	0
Thioctamide	940-69-2	Enzyme Replacements/modifiers	0
Tilarginine	17035-90-4	Enzyme Replacements/modifiers	0
Tolrestat	82964-04-3	Enzyme Replacements/modifiers	0
Tosedostat	238750-77-1	Enzyme Replacements/modifiers	0
Trandolaprilat	87679-71-8	Enzyme Replacements/modifiers	0
Trehalose-6-Phosphate	4484-88-2	Enzyme Replacements/modifiers	0
Ubiquinone Q1	727-81-1	Enzyme Replacements/modifiers	0
Vactosertib	1352608-82-2	Enzyme Replacements/modifiers	0
Vatiquinone	1213269-98-7	Enzyme Replacements/modifiers	0
Vernakalant	794466-70-9	Enzyme Replacements/modifiers	0
Vesnarinone	81840-15-5	Enzyme Replacements/modifiers	0
Volixibat	1025216-57-2	Enzyme Replacements/modifiers	0
Vorolanib	1013920-15-4	Enzyme Replacements/modifiers	0
Vutrisiran	1867157-35-4	Enzyme Replacements/modifiers	0
Zanubrutinib	1691249-45-2	Enzyme Replacements/modifiers	0
Zatolmilast	1606974-33-7	Enzyme Replacements/modifiers	0
Zenarestat	112733-06-9	Enzyme Replacements/modifiers	0
Zopolrestat	110703-94-1	Enzyme Replacements/modifiers	0
p-Hydroxymercuribenzoic acid	1126-48-3	Enzyme Replacements/modifiers	0