Hemin Chloride API Manufacturers & Suppliers
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Hemin | CAS No: 16009-13-5 | GMP-certified suppliers
A medication that manages acute intermittent porphyria attacks by reducing toxic porphyrin accumulation to alleviate neurological and visceral symptoms in affected patients.
Therapeutic categories
Primary indications
- Used in the management of porphyria attacks, particularly in acute intermittent porphyria
Product Snapshot
- Hemin is available as lyophilized powder and concentrate solutions for intravenous and parenteral injection
- It is primarily indicated for the management of porphyria attacks, specifically acute intermittent porphyria
- The product is approved and marketed in the US and Canada, with both approved and investigational statuses noted
Clinical Overview
Clinically, hemin operates by replenishing heme pools, which downregulates the hepatic synthesis of 5-aminolevulinic acid synthase 1 (ALAS1)—the rate-limiting enzyme in heme biosynthesis. By mitigating the accumulation of toxic porphyrin precursors, it helps to alleviate neurological and visceral symptoms associated with acute porphyric crises. Although detailed pharmacodynamics and explicit mechanistic data are limited in the provided dataset, its role in heme biosynthesis regulation is a widely accepted therapeutic principle.
Absorption, distribution, metabolism, and excretion parameters for hemin are typically influenced by its intravenous administration route in clinical use, resulting in rapid systemic availability. Metabolically, hemin is incorporated into heme-containing proteins or catabolized by heme oxygenase pathways, though precise ADME profiles may vary depending on formulation and patient condition.
Safety considerations include potential adverse effects related to intravenous delivery, such as infusion site reactions, phlebitis, and hypersensitivity. Careful monitoring during use is recommended, especially in patients with hepatic impairment or iron overload disorders.
From a sourcing perspective, due to its complex biological origin and stringent quality requirements, procurement of hemin APIs demands adherence to Good Manufacturing Practices (GMP) and thorough characterization of chemical purity, iron content, and absence of endotoxins. Reliable suppliers should provide comprehensive certificates of analysis to ensure consistent quality for pharmaceutical formulation.
Identification & chemistry
| Generic name | Hemin |
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| Molecule type | Biotech |
| CAS | 16009-13-5 |
| UNII | 743LRP9S7N |
| DrugBank ID | DB03404 |
Formulation & handling
- Hemin is administered parenterally as lyophilized powder or concentrate for intravenous injection, requiring aseptic reconstitution before use.
- As a biotech product, Hemin may be sensitive to temperature and light, necessitating controlled storage conditions to maintain stability.
- Formulations are designed for intravenous delivery only, with no oral or peptide/biologic classification indicated.
Regulatory status
| Lifecycle | The active pharmaceutical ingredient's patent protection expired in the US and Canada, resulting in widespread generic availability and a mature market with established competition. Ongoing regulatory approvals support continued presence in these regions. |
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| Markets | US, Canada |
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Supply Chain
| Supply chain summary | Hemin is supplied primarily by originator companies with branded products established in the US and Canadian markets. The consistent branding under Panhematin indicates a focused presence in these regions. Patent expiry status is not provided, so the potential for generic competition cannot be determined from the available data. |
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Hemin Chloride is a type of Hemostatics
Hemostatics, a subcategory of pharmaceutical active pharmaceutical ingredients (APIs), play a crucial role in promoting hemostasis, the process of blood clotting, to control bleeding. These essential medical substances are widely used in surgical procedures, trauma cases, and various medical conditions where excessive bleeding is a concern.
Hemostatics function by either promoting the aggregation of platelets or enhancing the coagulation cascade, thus facilitating clot formation and preventing blood loss. Several types of hemostatic agents are available, including topical agents, injectable agents, and absorbable sponges.
Topical hemostatic agents are commonly used in minor surgeries and dental procedures. These agents, such as oxidized regenerated cellulose and gelatin-based products, are applied directly to the bleeding site to induce clot formation and achieve hemostasis.
Injectable hemostatics, on the other hand, are administered intravenously or intramuscularly and work systemically to promote blood clotting. Examples of injectable hemostatics include recombinant factor VIIa and fibrinogen concentrates, which are employed in cases of severe bleeding or hemophilia.
Absorbable sponges, often made of gelatin or collagen, are frequently used in surgical procedures to control bleeding. These sponges absorb blood, swell, and create a physical barrier that supports clot formation.
Hemostatics have revolutionized medical practices by reducing blood loss during surgeries, improving patient outcomes, and minimizing the need for blood transfusions. They have become indispensable tools in various medical specialties, including cardiovascular surgery, orthopedics, and trauma care.
In conclusion, hemostatics are vital pharmaceutical APIs that promote hemostasis and prevent excessive bleeding. Their application in medical procedures ensures efficient clot formation and enhances patient safety.
Hemin Chloride (Hemostatics), classified under Central Nervous System Agents
Central Nervous System (CNS) Agents are a crucial category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that specifically target the central nervous system. The CNS encompasses the brain and spinal cord, playing a vital role in regulating and controlling various bodily functions, including cognition, movement, emotions, and sensory perception. These agents are designed to interact with specific receptors, enzymes, or ion channels within the CNS to modulate neural activity and restore normal functioning.
CNS agents comprise a diverse range of pharmaceutical APIs, including analgesics, anesthetics, antipsychotics, sedatives, hypnotics, anti-epileptics, and antidepressants. Each subcategory addresses distinct neurological disorders and conditions. For instance, analgesics alleviate pain by targeting receptors in the brain and spinal cord, while antipsychotics are employed to manage psychosis symptoms in mental illnesses such as schizophrenia.
The development of CNS agents involves rigorous research, molecular modeling, and extensive clinical trials to ensure safety, efficacy, and specific target engagement. Pharmaceutical companies invest significant resources in identifying novel drug targets, synthesizing new compounds, and optimizing their pharmacological properties. These agents undergo rigorous regulatory evaluations and must adhere to stringent quality standards and guidelines.
Given the prevalence of CNS disorders globally, the market demand for effective CNS agents is substantial. The development of innovative CNS APIs not only improves patient outcomes but also provides valuable commercial opportunities for pharmaceutical companies. Continued advancements in CNS agent research and development hold the promise of groundbreaking therapies that can improve the quality of life for individuals affected by neurological conditions.
Hemin Chloride API manufacturers & distributors
Compare qualified Hemin Chloride API suppliers worldwide. We currently have 1 companies offering Hemin Chloride API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Kraeber & Co GmbH | Producer | Germany | Germany | CoA, GDP, ISO9001, MSDS | 12 products |
When sending a request, specify which Hemin Chloride API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Hemin Chloride API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
