Central Nervous System Agents


Central Nervous System (CNS) Agents are a crucial category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that specifically target the central nervous system. The CNS encompasses the brain and spinal cord, playing a vital role in regulating and controlling various bodily functions, including cognition, movement, emotions, and sensory perception. These agents are designed to interact with specific receptors, enzymes, or ion channels within the CNS to modulate neural activity and restore normal functioning.

CNS agents comprise a diverse range of pharmaceutical APIs, including analgesics, anesthetics, antipsychotics, sedatives, hypnotics, anti-epileptics, and antidepressants. Each subcategory addresses distinct neurological disorders and conditions. For instance, analgesics alleviate pain by targeting receptors in the brain and spinal cord, while antipsychotics are employed to manage psychosis symptoms in mental illnesses such as schizophrenia.

The development of CNS agents involves rigorous research, molecular modeling, and extensive clinical trials to ensure safety, efficacy, and specific target engagement. Pharmaceutical companies invest significant resources in identifying novel drug targets, synthesizing new compounds, and optimizing their pharmacological properties. These agents undergo rigorous regulatory evaluations and must adhere to stringent quality standards and guidelines.

Given the prevalence of CNS disorders globally, the market demand for effective CNS agents is substantial. The development of innovative CNS APIs not only improves patient outcomes but also provides valuable commercial opportunities for pharmaceutical companies. Continued advancements in CNS agent research and development hold the promise of groundbreaking therapies that can improve the quality of life for individuals affected by neurological conditions.

NameCAS numberCategoryAmount of suppliers
(R)-1-phenylethanol1517-69-7Central Nervous System Agents1
1,1-Cyclohexanediacetic acid monoamide99189-60-3Central Nervous System Agents1
1,2,3,9-Tetrahydro-4(H)-Carbazol-4-One15128-52-6Central Nervous System Agents1
1-Methyl-3-Pyrrolidinol13220-33-2Central Nervous System Agents1
2-Butanol78-92-2Central Nervous System Agents1
2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one Hydrochloride151257-01-1Central Nervous System Agents1
2-Butyl-3-[[2'-cyano-[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4]non-1-en-4-one138401-24-8Central Nervous System Agents1
3,4-DimethoxyphenethylamineCentral Nervous System Agents1
3-Aminoquinuclidine DiHCl1691319Central Nervous System Agents2
3-Quinuclidinol1619-34-7Central Nervous System Agents2
3-Quinuclidinone HCl1193-65-3Central Nervous System Agents2
4-Diethylamino-2-Butyn-1-O110575-25-4Central Nervous System Agents1
4-Hydroxy-9H-Carbazole52602-39-8Central Nervous System Agents1
6-isoquinolinamine23687-26-5Central Nervous System Agents1
9,10-Dihydrolysergic acid5878-43-3Central Nervous System Agents1
9-Methyl-1,2,3,9-Tetrahydro-4H-Carbazol-4-One27387-31-1Central Nervous System Agents1
Acetylcholine51-84-3Cholinesterase inhibitors1
AcrivastineAntihistamines3
Adenosine triphosphate56-65-5Nervous System Agents6
Adrenaline tartrate51-42-3Adrenergic agents13
Alaproclate60719-82-6Central Nervous System Agents0
Alcaftadine147084-10-4Antihistamines8
Alcuronium23214-96-2Central Nervous System Agents0
Alizapride59338-93-1Dopamine antagonists1
Amantadine768-94-5Dopamine agonists10
Amfepramone HydrochloridePsychostimulants4
AmfetaminePsychostimulants1
Amibegron121524-08-1Central Nervous System Agents0
Amifampridine54-96-6Adrenergic agents3
Aminocaproic Acid60-32-2Hemostatics5
Amphetamine300-62-9Psychostimulants6
Antazoline91-75-8Antihistamines2
Apomorphine58-00-4Dopamine agonists7
Arformoterol67346-49-0Adrenergic agents5
Armodafinil112111-43-0Psychostimulants15
Atogepant1374248-81-3CGRP antagonists3
Atomoxetine83015-26-3Central Nervous System Agents23
Atracurium64228-79-1Central Nervous System Agents0
Bambuterol81732-65-2Adrenergic agents3
Bamifyline2016-63-9Adrenergic agents4
Bemegride64-65-3Central Nervous System Agents0
Benserazide14919-77-8Central Nervous System Agents6
Benzphetamine156-08-1Psychostimulants3
Bepotastine125602-71-3Antihistamines10
Bilastine202189-78-4Antihistamines13
Bornaprine20448-86-6Central Nervous System Agents0
Bremelanotide Acetate189691-06-3Other central nervous system agents1
Brofaromine63638-91-5Central Nervous System Agents0
Bromocriptine25614-03-3Dopamine agonists9
Bromopride4093-35-0Dopamine antagonists3
Brompheniramine86-22-6Antihistamines4
Buclizine82-95-1Antihistamines3
Budipine57982-78-2Central Nervous System Agents0
Bunazosin80755-51-7Central Nervous System Agents0
Butylamine109-73-9Adrenergic agents1
Butylphthalide6066-49-5Central Nervous System Agents0
Cabergoline81409-90-7Dopamine agonists18
Caffeine58-08-2Central Nervous System Agents21
Carbazochrome69-81-8Hemostatics5
Carbidopa28860-95-9Nervous System Agents20
Carbinoxamine486-16-8Antihistamines4
Casopitant414910-27-3Central Nervous System Agents0
Cerlapirdine925448-93-7Central Nervous System Agents0
Cetirizine83881-51-0Antihistamines42
Cetirizine HCl83881-52-1Antihistamines3
Chlorcyclizine82-93-9Antihistamines2
Chloropyramine59-32-5Antihistamines1
Chlorphenamine132-22-9Antihistamines19
Choline62-49-7Central Nervous System Agents14
Clemastine15686-51-8Antihistamines4
Clemastine fumarate610309-89-2Antihistamines1
Clobenzorex Hydrochloride5843-53-8Appetite suppressants 5
Conestat alfa80295-38-1Hemostatics1
Cutamesine165377-43-5Central Nervous System Agents0
Cyclizine82-92-8Antihistamines5
Cyclo(his-pro)53109-32-3Central Nervous System Agents0
Cyproheptadine129-03-3Antihistamines14
Daridorexant1505484-82-1Central Nervous System Agents0
Dasatinib302962-49-8Central Nervous System Agents27
Deanol108-01-0Central Nervous System Agents0
Denatonium47324-98-1Central Nervous System Agents0
Desloratadine100643-71-8Antihistamines37
Deutetrabenazine1392826-25-3Central Nervous System Agents0
Dexbrompheniramine132-21-8Antihistamines3
Dexchlorpheniramine maleateAntihistamines8
Dexmethylphenidate40431-64-9Central Nervous System Agents7
Dextroamphetamine51-64-9Central Nervous System Agents10
Dextrorphan125-73-5Central Nervous System Agents0
Diazoxide364-98-7Adrenergic agents5
Dihydroergocornine25447-65-8Central Nervous System Agents0
Dihydroergocristine17479-19-5Central Nervous System Agents0
Dimetindene maleate5636-83-9Antihistamines5
Diphenhydramine58-73-1Antihistamines27
Diphenylpyraline hydrochloride132-18-3Antihistamines1
Dipivefrin52365-63-6Adrenergic agents1
Diprenorphine14357-78-9Central Nervous System Agents0
Distigmine17299-00-2Central Nervous System Agents0
Domiphen13900-14-6Antihistamines1
Donepezil120014-06-4Cholinesterase inhibitors49
Dopamine51-61-6Adrenergic agents7
Dotarizine84625-59-2Central Nervous System Agents0
Doxylamine469-21-6Antihistamines9
Droxidopa23651-95-8Adrenergic agents10
Dynorphin80448-90-4Central Nervous System Agents0
Ebastine90729-43-4Antihistamines15
Echothiophate6736-03-4Cholinesterase inhibitors1
EdrophoniumCholinesterase inhibitors1
Eletriptan143322-58-1Selective 5HT1-agonists15
Eliprodil119431-25-3Central Nervous System Agents0
Eltoprazine98224-03-4Central Nervous System Agents0
Emedastine87233-61-2Antihistamines4
Enadoline124378-77-4Central Nervous System Agents0
Entacapone130929-57-6COMT inhibitors25
Ephedrine299-42-3Adrenergic agents11
Epinastine80012-43-7Antihistamines15
Epinephrine51-43-4Adrenergic agents14
Eplivanserin130579-75-8Central Nervous System Agents0
Esreboxetine98819-76-2Central Nervous System Agents0
Etamsylate2624-44-4Hemostatics5
Ethanolamine Oleate2272-11-9Sclerosing agents1
Etilefrine709-55-7Adrenergic agents3
Etybenzatropine524-83-4Central Nervous System Agents0
Fazadinium bromide49564-56-9Central Nervous System Agents0
Fenyramidol553-69-5Central Nervous System Agents0
Fexofenadine83799-24-0Antihistamines47
Flibanserin167933-07-5Psychopharmaceuticals5
Florbetaben F-18902143-01-5Central Nervous System Agents0
Florbetapir (18F)956103-76-7Central Nervous System Agents0
Fluoxetine54910-89-3Serotonin reuptake inhibitors23
Flutemetamol (18F)765922-62-1Central Nervous System Agents0
Fluvoxamine54739-18-3Serotonin reuptake inhibitors19
Formoterol73573-87-2Adrenergic agents23
Frovatriptan158747-02-5Selective 5HT1-agonists6
Gacyclidine68134-81-6Central Nervous System Agents0
Galantamine357-70-0Central Nervous System Agents12
Gallamine153-76-4Central Nervous System Agents0
Gamma-Aminobutyric acid56-12-2Central Nervous System Agents1
Gepirone83928-76-1Central Nervous System Agents1
Ginsenoside Rg122427-39-0Central Nervous System Agents0
Griffonia simplicifolia 30%5HT2 antagonists1
Guanidine113-00-8Adrenergic agents1
Harmine442-51-3Central Nervous System Agents0
Hemin Chloride16009-13-5Hemostatics1
Huperzine A102518-79-6Central Nervous System Agents7
Hydroxyamphetamine hydrobromideAdrenergic agents1
Hydroxyzine68-88-2Antihistamines7
Ibopamine66195-31-1Central Nervous System Agents0
Idalopirdine467459-31-0Central Nervous System Agents0
Idebenone58186-27-9Other central nervous system agents11
Ifenprodil23210-56-2NMDA antagonists2
Imepitoin188116-07-6Central Nervous System Agents1
Indacaterol Maleate312753-06-3Adrenergic agents4
Indiplon325715-02-4Central Nervous System Agents0
Inotersen1492984-65-2Central Nervous System Agents0
Ipidacrine62732-44-9Central Nervous System Agents0
Isocarboxazid59-63-2MAO inhibitors3
Isoprenaline7683-59-2Adrenergic agents17
Isopropyl Nortropine3423-25-4Adrenergic agents1
Isothipendyl482-15-5Antihistamines1
Isoxsuprine395-28-8Adrenergic agents6
Isoxsuprine HydrochlorideAdrenergic agents2
Ketanserin tartrate83846-83-75HT2 antagonists3
Ketotifen34580-13-7Antihistamines10
Ketotifen fumarate34580-14-8Antihistamines1
Kynurenic Acid492-27-3Central Nervous System Agents0
L-Glutamic Acid56-86-0Central Nervous System Agents12
Lafutidine118288-08-7Central Nervous System Agents1
Landiolol133242-30-5Central Nervous System Agents0
Lanicemine153322-05-5Central Nervous System Agents0
Lasmiditan439239-90-4Serotonin receptor agonists2
Levocabastine79516-68-0Antihistamines5
Levocetirizine130018-77-8Antihistamines19
Levocetirizine Dihydrochloride130018-87-0Antihistamines9
Levocetirizine HydrochlorideAntihistamines11
Levodopa59-92-7Dopamine agonists22
Levomefolic acid31690-09-2Central Nervous System Agents1
Levomethadone125-58-6Central Nervous System Agents0
Levonordefrin829-74-3Adrenergic agents1
Linopirdine105431-72-9Central Nervous System Agents0
Lisdexamfetamine608137-32-2Amphetamine6
Lisuride18016-80-3Dopamine agonists2
Lithium7439-93-2Lithium salts7
Lithium chloride7447-41-8Central Nervous System Agents0
Lomerizine101477-55-8Central Nervous System Agents0
Loratadine79794-75-5Antihistamines37
Mazaticol42024-98-6Central Nervous System Agents0
Mebhydrolin NapadisylateAntihistamines1
Mebhydroline Napadisylate6153-33-9Antihistamines2
Mecamylamine60-40-2Nicotinic acid derivatives1
Meclizine569-65-3Antihistamines16
Memantine19982-08-2Nervous System Agents34
Mepyramine91-84-9Antihistamines7
Mequitazine29216-28-2Antihistamines3
Metaraminol54-49-9Adrenergic agents3
Metenkefalin58569-55-4Central Nervous System Agents0
Methamphetamine537-46-2Psychostimulants1
Methsuximide77-41-8Adrenergic agents1
Methylphenidate113-45-1Psychostimulants23
Metoclopramide364-62-5Dopamine antagonists21
Metyrosine672-87-7Adrenergic agents3
Mexiletine31828-71-4Adrenergic agents7
Midodrine42794-76-3Adrenergic agents14
Mizolastine108612-45-9Antihistamines2
Modafinil68693-11-8Central Nervous System Agents23
Naftidrofuryl31329-57-4Central Nervous System Agents1
Naluzotan740873-06-7Central Nervous System Agents0
Namodenoson163042-96-4Central Nervous System Agents0
Naratriptan121679-13-8Selective 5HT1-agonists7
Naronapride860174-12-5Central Nervous System Agents0
Nelotanserin839713-36-9Central Nervous System Agents0
Neostigmine59-99-4Cholinesterase inhibitors16
Netupitant290297-26-6Neurokinin antagonists5
Nikethamide59-26-7Central Nervous System Agents0
Nizofenone54533-85-6Central Nervous System Agents0
Noradrenaline Tartrate108341-18-0Adrenergic agents8
Noradrenaline hydrochlorideAdrenergic agents1
Nordazepam1088-11-5Central Nervous System Agents0
Norepinephrine51-41-2Adrenergic agents9
Olodaterol868049-49-4Adrenergic agents1
Olopatadine113806-05-6Antihistamines23
Opicapone923287-50-7Dopamine agonists0
Orciprenaline586-06-1Adrenergic agents3
Oxatomide60607-34-3Antihistamines4
Oxitriptan4350-09-8Serotonin receptor agonists2
Patisiran1420706-45-1Central Nervous System Agents0
Pemoline2152-34-3Central Nervous System Agents1
Pentetrazol54-95-5Central Nervous System Agents0
Pergolide66104-22-1Dopamine agonists5
Phendimetrazine634-03-7Appetite suppressants 1
Phenelzine51-71-8MAO inhibitors3
Phenethylamine64-04-0Central Nervous System Agents0
Phenglutarimide1156-05-4Central Nervous System Agents0
Phenibut1078-21-3Central Nervous System Agents2
Pheniramine86-21-5Antihistamines9
Phenprobamate673-31-4Central Nervous System Agents0
Phentermine122-09-8Appetite suppressants 7
Phenylpropanolamine14838-15-4Adrenergic agents1
Phenyltoloxamine Citrate3717-88-2Antihistamines1
Piclozotan182415-09-4Central Nervous System Agents0
Piflufolastat F 181207181-29-0Central Nervous System Agents0
Pipequaline77472-98-1Central Nervous System Agents0
Pipradrol467-60-7Central Nervous System Agents0
Piribedil3605-01-4Other central nervous system agents1
Polidocanol9002-92-0Sclerosing agents3
Pramipexole104632-26-0Dopamine agonists32
Pramiracetam68497-62-1Other central nervous system agents2
Procaterol72332-33-3Adrenergic agents1
Prolintane493-92-5Central Nervous System Agents0
Promethazine60-87-7Antihistamines21
Propentofylline55242-55-2Central Nervous System Agents0
Protamine sulfate9009-65-8Hemostatics4
Pseudoephedrine90-82-4Adrenergic agents18
Psilocybin520-52-5Central Nervous System Agents1
Pyrazolam39243-02-2Central Nervous System Agents0
Pyritinol1098-97-1Central Nervous System Agents0
Pyroglutamate149-87-1Nervous System Agents2
Quisqualic acid52809-07-1Central Nervous System Agents0
R-(-)-3-Quinuclidinol25333-42-0Neurokinin antagonists3
Racepinephrine HCl329-63-5Adrenergic agents1
Rasagiline136236-51-6MAO inhibitors17
Repinotan144980-29-0Central Nervous System Agents0
Riluzole1744-22-5Central Nervous System Agents12
Rimegepant sulfate1374024-48-2CGRP antagonists4
Ritobegron255734-04-4Central Nervous System Agents0
Rivastigmine123441-03-2Cholinesterase inhibitors28
Rivastigmine hydrogen tartrateCholinesterase inhibitors16
Rizatriptan144034-80-0Serotonin receptor agonists22
Ropinirole91374-21-9Dopamine agonists14
Rotigotine99755-59-6Dopamine agonists13
RupatadineAntihistamines9
S-Ethylisothiourea2986-20-1Central Nervous System Agents0
Safinamide methanesulfonate946075-13-4Other central nervous system agents1
Salvinorin A83729-01-5Central Nervous System Agents0
Sapropterin62989-33-7Central Nervous System Agents2
Sarpogrelate125926-17-2Central Nervous System Agents0
Selegiline hydrochloride14611-51-9Dopamine agonists6
Seletracetam357336-74-4Central Nervous System Agents0
Sodium Tetradecyl Sulfate139-88-8Sclerosing agents2
Sodium ferric gluconate complexHemostatics1
Solriamfetol178429-62-4Central Nervous System Agents0
Strychnine57-24-9Central Nervous System Agents0
Styramate94-35-9Central Nervous System Agents0
Sucrosofate57680-56-5Hemostatics1
Sumatriptan Succinate103628-46-2Selective 5HT1-agonists29
Synephrine94-07-5Adrenergic agents7
Tandospirone87760-53-0Central Nervous System Agents0
Technetium Tc-99m exametazime99944-78-2Central Nervous System Agents0
Tenocyclidine21500-98-1Psychopharmaceuticals1
Terameprocol24150-24-1Central Nervous System Agents0
Terbutaline23031-25-6Adrenergic agents9
Tetrabenazine58-46-8Other central nervous system agents12
ThrombinHemostatics3
Tolcapone134308-13-7COMT inhibitors5
Tolperisone728-88-1Central Nervous System Agents1
Tranylcypromine155-09-9MAO inhibitors3
Trihexyphenidyl144-11-6Nervous System Agents6
Triprolidine486-12-4Antihistamines13
Tritoqualine14504-73-5Central Nervous System Agents0
Tropatepine27574-24-9Central Nervous System Agents0
Tyramine51-67-2Adrenergic agents2
Ubrogepant1374248-77-7CGRP antagonists3
Valbenazine1025504-45-3Central Nervous System Agents0
Vilanterol503068-34-6Adrenergic agents0
Vinpocetine42971-09-5Central Nervous System Agents5
Volinanserin139290-65-6Central Nervous System Agents0
Xaliproden135354-02-8Central Nervous System Agents0
Xanomeline131986-45-3Central Nervous System Agents0
Xylometazoline526-36-3Adrenergic agents11
Ziconotide107452-89-1Central Nervous System Agents2
Zolazepam31352-82-6Central Nervous System Agents0
Zolmitriptan139264-17-8Selective 5HT1-agonists23
Zuranolone1632051-40-1Central Nervous System Agents1
gabapentin enacarbil478296-72-9Central Nervous System Agents2