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Caprylic acid | CAS No: 124-07-2 | GMP-certified suppliers
A medication that serves as an investigational medium-chain fatty acid with potential benefits in renal drug transport modulation and metabolic support in lipid-related conditions.
Therapeutic categories
Product Snapshot
- Caprylic acid is an oral small molecule formulation
- It is primarily used as an investigational agent in metabolic and neurological disorders
- The compound currently holds an investigational status without formal approval from major regulatory agencies such as FDA or EMA
Clinical Overview
This compound is categorized within organic chemistry as a medium-chain fatty acid, characterized by carbon chains ranging from four to twelve atoms. Although caprylic acid itself does not have a specified clinical indication or approved therapeutic use, it is recognized for its investigational status. It is classified pharmacologically as an inhibitor of the organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8), which are involved in renal drug transport processes.
Detailed pharmacodynamic and mechanism of action profiles for caprylic acid remain to be fully elucidated in clinical contexts. Its role as an organic acid with lipid characteristics implies potential interactions at cellular membranes and possible metabolic involvement in fatty acid oxidation pathways. ADME (Absorption, Distribution, Metabolism, Excretion) data specific to caprylic acid are limited; however, medium-chain fatty acids typically demonstrate rapid absorption and hepatic metabolism via beta-oxidation, with minimal accumulation due to efficient clearance.
Safety and toxicity data on caprylic acid are sparse; as a naturally occurring dietary fatty acid, it exhibits a relatively favorable safety profile in standard exposure scenarios. Nonetheless, investigational use and pharmaceutical-grade preparations require stringent evaluation for impurities and consistent physicochemical properties, especially given its oily nature and odor.
No notable pharmaceutical brands currently market caprylic acid as an active pharmaceutical ingredient. It is primarily utilized in research settings and as an excipient or intermediate in other chemical syntheses.
For API sourcing, quality control should focus on purity, absence of residual solvents, and compliance with relevant pharmacopeial standards. Stability under storage conditions and container compatibility are also important given caprylic acid’s physicochemical properties. Reliable supply chains with documentation ensuring traceability and consistent batch quality are essential for formulation and regulatory requirements.
Identification & chemistry
| Generic name | Caprylic acid |
|---|---|
| Molecule type | Small molecule |
| CAS | 124-07-2 |
| UNII | OBL58JN025 |
| DrugBank ID | DB04519 |
Pharmacology
Targets
| Target | Organism | Actions |
|---|---|---|
| Peroxisome proliferator-activated receptor alpha | Humans | |
| 3-oxoacyl-[acyl-carrier-protein] synthase 1 | Escherichia coli (strain K12) | |
| Acyl-CoA thioesterase I | Escherichia coli (strain K12) |
Formulation & handling
- Caprylic acid is a small molecule medium-chain fatty acid primarily suited for oral formulations due to its lipophilic nature and moderate water solubility.
- Given its liquid state and lipophilicity (logP 2.7), formulation strategies should address solubility enhancement for consistent bioavailability.
- Stability considerations include protection from oxidation and photodegradation during storage and handling to maintain compound integrity.
Regulatory status
Safety
| Toxicity | Oral rat LD<sub>50</sub>: 10080 mg/kg. Intravenous mouse LD<sub>50</sub>: 600 mg/kg. Skin rabbit LD<sub>50</sub>: over 5000 mg/kg. |
|---|
- Moderate acute toxicity observed via intravenous route in murine models (LD₅₀: 600 mg/kg)
- High oral and dermal LD₅₀ values indicate lower systemic toxicity in these exposure routes (oral rat LD₅₀: 10,080 mg/kg
- Dermal rabbit LD₅₀: ›5,000 mg/kg)
Caprylic acid is a type of Lipid-lowering agents
Lipid-lowering agents are a category of pharmaceutical active ingredients (APIs) that are widely used in the treatment of hyperlipidemia, a condition characterized by elevated levels of lipids (such as cholesterol and triglycerides) in the blood. These agents play a crucial role in managing lipid abnormalities and reducing the risk of cardiovascular diseases.
One of the most commonly prescribed lipid-lowering agents is statins. Statins work by inhibiting an enzyme called HMG-CoA reductase, which is responsible for the production of cholesterol in the liver. By blocking this enzyme, statins effectively lower cholesterol levels in the bloodstream.
Another class of lipid-lowering agents is fibric acid derivatives, which primarily target triglyceride levels. These agents activate a nuclear receptor known as PPAR-alpha, which regulates lipid metabolism. By activating PPAR-alpha, fibric acid derivatives enhance the breakdown of triglycerides and increase the elimination of fatty acids from the bloodstream.
Additionally, bile acid sequestrants are often used as lipid-lowering agents. These agents bind to bile acids in the intestine, preventing their reabsorption. As a result, the liver utilizes more cholesterol to produce new bile acids, leading to a decrease in circulating cholesterol levels.
Lipid-lowering agents are available in various formulations, including tablets, capsules, and suspensions, allowing for convenient administration. They are usually prescribed alongside lifestyle modifications, such as dietary changes and regular exercise, to optimize the management of hyperlipidemia.
It is important to note that the use of lipid-lowering agents should be under the supervision of a healthcare professional, as they may have potential side effects and interactions with other medications. Proper monitoring of lipid levels and regular follow-up visits are essential for ensuring the effectiveness and safety of these pharmaceutical agents.
Caprylic acid API manufacturers & distributors
Compare qualified Caprylic acid API suppliers worldwide. We currently have 1 companies offering Caprylic acid API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Pharm Rx Chemical Corp | Distributor | United States | China | BSE/TSE, CoA, GMP, MSDS | 166 products |
When sending a request, specify which Caprylic acid API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Caprylic acid API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
