Lipid-lowering agents


Lipid-lowering agents are a category of pharmaceutical active ingredients (APIs) that are widely used in the treatment of hyperlipidemia, a condition characterized by elevated levels of lipids (such as cholesterol and triglycerides) in the blood. These agents play a crucial role in managing lipid abnormalities and reducing the risk of cardiovascular diseases.

One of the most commonly prescribed lipid-lowering agents is statins. Statins work by inhibiting an enzyme called HMG-CoA reductase, which is responsible for the production of cholesterol in the liver. By blocking this enzyme, statins effectively lower cholesterol levels in the bloodstream.

Another class of lipid-lowering agents is fibric acid derivatives, which primarily target triglyceride levels. These agents activate a nuclear receptor known as PPAR-alpha, which regulates lipid metabolism. By activating PPAR-alpha, fibric acid derivatives enhance the breakdown of triglycerides and increase the elimination of fatty acids from the bloodstream.

Additionally, bile acid sequestrants are often used as lipid-lowering agents. These agents bind to bile acids in the intestine, preventing their reabsorption. As a result, the liver utilizes more cholesterol to produce new bile acids, leading to a decrease in circulating cholesterol levels.

Lipid-lowering agents are available in various formulations, including tablets, capsules, and suspensions, allowing for convenient administration. They are usually prescribed alongside lifestyle modifications, such as dietary changes and regular exercise, to optimize the management of hyperlipidemia.

It is important to note that the use of lipid-lowering agents should be under the supervision of a healthcare professional, as they may have potential side effects and interactions with other medications. Proper monitoring of lipid levels and regular follow-up visits are essential for ensuring the effectiveness and safety of these pharmaceutical agents.

NameCAS numberCategoryAmount of suppliersAPI market price
Acipimox51037-30-0Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Alirocumab1245916-14-6PCSK9-inhibitorsView 2 Suppliers Average price per kg: $
Aloxistatin88321-09-9Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Atorvastatin134523-00-5Lipid-lowering agentsView 78 Suppliers Average price per kg: $
Bempedoic Acid738606-46-7Lipid-lowering agentsView 9 Suppliers Average price per kg: $
Bezafibrate41859-67-0FibratesView 7 Suppliers Average price per kg: $
Capric triglyceride123465-33-8Lipid-lowering agentsView 2 Suppliers Average price per kg: $
Caprylic acid124-07-2Lipid-lowering agentsView 2 Suppliers Average price per kg: $
Cholesterol57-88-5Lipid-lowering agentsView 12 Suppliers Average price per kg: $
Choline Fenofibrate856676-23-8Lipid-lowering agentsView 4 Suppliers Average price per kg: $
Ciclonicate53449-58-4Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Ciprofibrate52214-84-3FibratesView 8 Suppliers Average price per kg: $
Clofibrate637-07-0FibratesView 1 Suppliers Average price per kg: $
Clofibride26717-47-5Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Evolocumab1256937-27-5Lipid-lowering agentsView 1 Suppliers Average price per kg: $
Ezetimibe163222-33-1Lipid-lowering agentsView 44 Suppliers Average price per kg: $
Fenofibrate49562-28-9Lipid-lowering agentsView 36 Suppliers Average price per kg: $
Fenofibric acid42017-89-0Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Fluvastatin93957-54-1StatinsView 16 Suppliers Average price per kg: $
Icosapent10417-94-4Lipid-lowering agentsView 1 Suppliers Average price per kg: $
Icosapent ethyl86227-47-6Lipid-lowering agentsView 6 Suppliers Average price per kg: $
Inclisiran1639324-58-5Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Inositol nicotinate6556-11-2Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Lomitapide182431-12-5Lipid-lowering agentsView 3 Suppliers Average price per kg: $
Lovastatin75330-75-5StatinsView 20 Suppliers Average price per kg: $
Mevastatin73573-88-3StatinsView 5 Suppliers Average price per kg: $
Niceritrol5868-05-3Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Nicofuranose15351-13-0Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Omega-3-acid ethyl estersLipid-lowering agentsView 6 Suppliers Average price per kg: $
Omega-3-acid ethyl esters 60Lipid-lowering agentsView 1 Suppliers Average price per kg: $
Omega-3-acid ethyl esters 90Lipid-lowering agentsView 7 Suppliers Average price per kg: $
Omega-3-acid triglyceridesLipid-lowering agentsView 3 Suppliers Average price per kg: $
Omega-3-carboxylic acidsLipid-lowering agentsView 2 Suppliers Average price per kg: $
Orlistat96829-58-2Lipid-lowering agentsView 24 Suppliers Average price per kg: $
Pitavastatin147511-69-1StatinsView 26 Suppliers Average price per kg: $
Pravastatin81093-37-0StatinsView 10 Suppliers Average price per kg: $
Probucol23288-49-5Lipid-lowering agentsView 2 Suppliers Average price per kg: $
Ronifibrate42597-57-9Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Rosuvastatin287714-41-4StatinsView 86 Suppliers Average price per kg: $
Simfibrate14929-11-4Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Simvastatin79902-63-9Lipid-lowering agentsView 36 Suppliers Average price per kg: $
Sodium Cholesteryl sulfate2864-50-8Lipid-lowering agentsView 2 Suppliers Average price per kg: $
Sodium apolate25053-27-4Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Tiadenol6964-20-1Lipid-lowering agentsView 0 Suppliers Average price per kg: $
Trepibutone41826-92-0Lipid-lowering agentsView 1 Suppliers Average price per kg: $
TriglyceridesLipid-lowering agentsView 1 Suppliers Average price per kg: $
Volanesorsen915430-78-3Lipid-lowering agentsView 0 Suppliers Average price per kg: $