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Pazufloxacin | CAS No: 127045-41-4 | GMP-certified suppliers
A medication that provides antibacterial activity for systemic infections and tuberculosis treatment, with potential benefits in managing mycobacterial diseases and moderate CYP1A2 inhibition.
Therapeutic categories
Product Snapshot
- Pazufloxacin is an oral small molecule antibiotic formulation
- It is primarily used for treating bacterial infections
- The compound is currently in an investigational regulatory status without full market approval
Clinical Overview
Although a specific clinical indication for pazufloxacin has not been established, the molecule is currently under clinical investigation, as indicated by its inclusion in trial NCT02592096, which evaluates pazufloxacin mesilate formulated as ear drops. Its categorization as an anti-bacterial for systemic use and as a drug for tuberculosis treatment highlights its potential utility against bacterial infections, including mycobacterial pathogens.
From a pharmacological perspective, pazufloxacin acts as a topoisomerase II inhibitor, interfering with bacterial DNA replication and transcription. This mechanism of action is common among fluoroquinolones, which target bacterial DNA gyrase and topoisomerase IV, enzymes essential for maintaining DNA topology and integrity. Additionally, pazufloxacin exhibits moderate inhibitory effects on cytochrome P450 CYP1A2, which may have clinical relevance in drug-drug interaction profiles.
Key ADME parameters, including absorption, distribution, metabolism, and excretion properties of pazufloxacin, have not been extensively detailed in public literature. However, as a member of the fluoroquinolone class, it may share characteristics such as oral bioavailability, renal excretion, and potential for tissue penetration, pending confirmation from pharmacokinetic studies.
Safety considerations include its classification as a potential QTc-prolonging agent, which necessitates caution in patients with risk factors for arrhythmia. No comprehensive toxicity data are publicly available at this stage of development.
For pharmaceutical manufacturing and sourcing, pazufloxacin requires procurement from suppliers capable of providing high-purity API conforming to stringent regulatory standards. Given its investigational status, quality attributes such as polymorphic form, residual solvents, and impurity profiles should be thoroughly characterized to support formulation and regulatory submissions.
Identification & chemistry
| Generic name | Pazufloxacin |
|---|---|
| Molecule type | Small molecule |
| CAS | 127045-41-4 |
| UNII | 4CZ1R38NDI |
| DrugBank ID | DB11774 |
Formulation & handling
- Pazufloxacin is a small molecule quinoline carboxylic acid with favorable water solubility suitable for oral formulation.
- Its low LogP value (-1) indicates a hydrophilic nature, potentially influencing absorption and distribution profiles.
- Stability considerations should include protection from moisture given its investigational status and solubility characteristics.
Regulatory status
Pazufloxacin is a type of Quinolones
Quinolones belong to a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs). They are a group of synthetic antibiotics that possess a broad-spectrum activity against various bacterial infections. This technical description will shed light on the key characteristics and applications of quinolones.
Quinolones exhibit potent bactericidal activity by targeting DNA gyrase and topoisomerase IV, which are essential enzymes for bacterial DNA replication and repair. This mechanism of action distinguishes quinolones from other classes of antibiotics, making them effective against both Gram-positive and Gram-negative bacteria.
The versatility of quinolones enables their application in the treatment of a wide range of infections, including respiratory tract infections, urinary tract infections, gastrointestinal infections, skin and soft tissue infections, and sexually transmitted diseases. Furthermore, they have proven efficacy against bacteria resistant to other antibiotics, making them indispensable in clinical practice.
Pharmaceutical companies utilize advanced manufacturing processes to synthesize quinolones with high purity and quality. Stringent quality control measures ensure the safety and efficacy of these APIs, complying with regulatory standards.
Quinolones have revolutionized the field of antibacterial therapy, providing healthcare professionals with potent tools to combat bacterial infections. However, it is crucial to utilize them judiciously to prevent the emergence of antibiotic resistance.
In conclusion, quinolones, as a subcategory of pharmaceutical APIs, possess remarkable antibacterial properties, making them invaluable in the treatment of various infections. Their broad-spectrum activity, mechanism of action, and effectiveness against resistant bacteria make quinolones a crucial component of modern healthcare.
Pazufloxacin (Quinolones), classified under Anti-infective Agents
Anti-infective agents are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used in the treatment of various infectious diseases. These agents play a crucial role in combating bacterial, viral, fungal, and parasitic infections. The demand for effective anti-infective APIs has grown significantly due to the increasing prevalence of drug-resistant microorganisms.
Anti-infective APIs encompass a wide range of substances, including antibiotics, antivirals, antifungals, and antiparasitics. Antibiotics are particularly important in fighting bacterial infections and are further categorized into different classes based on their mode of action and target bacteria. Antivirals are designed to inhibit viral replication and are essential in the treatment of viral infections such as influenza and HIV. Antifungals combat fungal infections, while antiparasitics are used to eliminate parasites that cause diseases like malaria and helminthiasis.
The development and production of high-quality anti-infective APIs require stringent manufacturing processes and adherence to regulatory standards. Pharmaceutical companies invest heavily in research and development to discover new and more effective anti-infective agents. Additionally, ensuring the safety, efficacy, and stability of these APIs is of utmost importance.
The global market for anti-infective APIs is driven by factors such as the rising incidence of infectious diseases, the emergence of new and drug-resistant pathogens, and the growing demand for improved healthcare infrastructure. Continuous advancements in pharmaceutical technology and the development of innovative drug delivery systems further contribute to the expansion of this market.
In conclusion, anti-infective agents are a critical category of pharmaceutical APIs that play a pivotal role in treating infectious diseases. Their effectiveness in combating various types of infections makes them essential components in the arsenal of modern medicine.
Pazufloxacin API manufacturers & distributors
Compare qualified Pazufloxacin API suppliers worldwide. We currently have 2 companies offering Pazufloxacin API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Xellia (Taizhou) | Producer | China | China | CoA, WC | 8 products |
| Zhejiang Haisen Pharma | Producer | China | China | CoA, WC | 7 products |
When sending a request, specify which Pazufloxacin API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Pazufloxacin API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
