Alclofenac API Manufacturers
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Looking for Alclofenac API 22131-79-9?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Alclofenac. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Alclofenac
- Synonyms:
- (4-Allyloxy-3-chlorphenyl)essigsäure , [4-(allyloxy)-3-chlorophenyl]acetic acid , 3-Chloro-4-(2-propenyloxy)benzeneacetic acid , Alclofénac , Alclofenaco , Alclofenacum , Alclophenac
- Cas Number:
- 22131-79-9
- DrugBank number:
- DB13167
- Unique Ingredient Identifier:
- M9CP5H21N8
General Description:
Alclofenac, identified by CAS number 22131-79-9, is a notable compound with significant therapeutic applications. Alclofenac is a non-steroidal anti-inflammatory drug. It was withdrawn from the market in the United Kingdom in 1979.
Indications:
This drug is primarily indicated for: Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Alclofenac undergoes metabolic processing primarily in: the main metabolic product is alclofenac itself and alclofenac glucuronide. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Alclofenac are crucial for its therapeutic efficacy: The absorption of alclofenac from the gastrointestinal tract is irregular. After oral or rectal administration maximum plasma concentrations are reached within 1-4 hours. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Alclofenac is an important consideration for its dosing schedule: The plasma half-life varies between 1.5 and 5.5 hours. This determines the duration of action and helps in formulating effective dosing regimens.
Protein Binding:
Alclofenac exhibits a strong affinity for binding with plasma proteins: The binding to plasma proteins is 90-99%. This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Route of Elimination:
The elimination of Alclofenac from the body primarily occurs through: Alclofenac is excreted in the urine mainly as glucuronide and as unchanged active substance. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Alclofenac is distributed throughout the body with a volume of distribution of: The volume of distribution is 0.1 L / kg. This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Alclofenac is a critical factor in determining its safe and effective dosage: For oral dose of 500mg: Renal clearance constant (av) 35ml/min Overall clearance constant (av) 37-69ml/min. It reflects the efficiency with which the drug is removed from the systemic circulation.
Mechanism of Action:
Alclofenac functions by: Alclofenac is an inhibitor of prostaglandin H2 synthase. The inhibition of the enzyme occurs through the reversible block of cyclooxygenase enzyme. Therefore, it prevents the production of inflammatory mediators (and pain) as prostacyclins and prostaglandins. Aclofenac has the ability to inhibit the biosynthesis of prostaglandins which may be an important factor in the action of these drugs, but in addition, the effect of these agents in displacing endogenous anti-inflammatory substances from plasma protein binding sites is thought to be an equally important effect in their mechanism of action. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Classification:
Alclofenac belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring, classified under the direct parent group Phenol ethers. This compound is a part of the Organic compounds, falling under the Benzenoids superclass, and categorized within the Phenol ethers class, specifically within the None subclass.
Categories:
Alclofenac is categorized under the following therapeutic classes: Acetic Acid Derivatives and Related Substances, Acids, Carbocyclic, Agents causing hyperkalemia, Agents that produce hypertension, Analgesics, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Anti-Inflammatory Agents, Non-Steroidal, Antiinflammatory and Antirheumatic Products, Antiinflammatory and Antirheumatic Products, Non-Steroids, Antirheumatic Agents, Drugs that are Mainly Renally Excreted, Musculo-Skeletal System, Nephrotoxic agents, Non COX-2 selective NSAIDS, Peripheral Nervous System Agents, Sensory System Agents. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Alclofenac is a type of Analgesics
Analgesics are a category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that are commonly used to relieve pain. They are designed to alleviate discomfort by targeting the body's pain receptors or by reducing inflammation. Analgesics are widely utilized in the medical field to manage various types of pain, ranging from mild to severe.
One of the primary classes of analgesics is nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by inhibiting the production of prostaglandins, substances that contribute to pain and inflammation. This class includes well-known drugs like ibuprofen and naproxen. Another class of analgesics is opioids, which are derived from opium or synthetic compounds that mimic the effects of opium. Opioids act on the central nervous system to reduce pain perception and provide potent pain relief. Examples of opioids include morphine, codeine, and oxycodone.
Analgesics are available in various forms, such as tablets, capsules, creams, and injections, allowing for different routes of administration based on the patient's needs. They are commonly used to manage pain associated with conditions like arthritis, headaches, dental procedures, and post-operative recovery.
It is important to note that analgesics should be used under medical supervision, as improper use or overuse can lead to adverse effects, including gastrointestinal complications, addiction, and respiratory depression in the case of opioids. Therefore, it is crucial for healthcare professionals to assess each patient's individual needs and prescribe the appropriate analgesic and dosage.
In summary, analgesics are a vital category of pharmaceutical APIs used to alleviate pain by targeting pain receptors or reducing inflammation. With various classes and forms available, they provide valuable options for pain management when used responsibly and under medical guidance.
