Andrographolide API Manufacturers
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Looking for Andrographolide API 5508-58-7?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Andrographolide. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Andrographolide
- Synonyms:
- 3α,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid γ-Lactone
- Cas Number:
- 5508-58-7
- DrugBank number:
- DB05767
- Unique Ingredient Identifier:
- 410105JHGR
General Description:
Andrographolide, identified by CAS number 5508-58-7, is a notable compound with significant therapeutic applications. Andrographolide (HMPL-004) is a botanical product extracted from a herb that occurs naturally in China. The herb has an extensive history of use in TCM for the treatment of upper respiratory tract infections and other inflammatory and infectious diseases.
Indications:
This drug is primarily indicated for: Investigated for use/treatment in ulcerative colitis. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Mechanism of Action:
Andrographolide functions by: HMPL-004 acts on multiple cellular targets in the inflammatory signal transduction pathways resulting in suppressed inflammation cytokine expression including TNF-α, IL-1β and IL-6. HMPL-004 was demonstrated to inhibit TNF-α and IL-1β production in cell-based assays. HMPL-004 is also able to inhibit NF-kB activation. NF-kB is a family of transcriptional factors that regulate a wide spectrum of genes critically involved in host defence and inflammation. The mechanism of action of HMPL-004 was further supported in laboratory IBD animal models. Treatment of IBD rats with HMPL-004 caused a significant drop in plasma cytokine concentrations, including TNF-α and IL-1β. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Andrographolide belongs to the class of organic compounds known as gamma butyrolactones. These are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom, classified under the direct parent group Gamma butyrolactones. This compound is a part of the Organic compounds, falling under the Organoheterocyclic compounds superclass, and categorized within the Lactones class, specifically within the Gamma butyrolactones subclass.
Categories:
Andrographolide is categorized under the following therapeutic classes: Analgesics, Analgesics, Non-Narcotic, Anti-Infective Agents, Anti-Inflammatory Agents, Antiparasitic Agents, Antiplatelet agents, Antiprotozoals, Antirheumatic Agents, Biological Products, Colitis, Ulcerative, drug therapy, Hematologic Agents, Peripheral Nervous System Agents, Plant Preparations, Sensory System Agents, Stereoisomerism, Terpenes. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Andrographolide is a type of Analgesics
Analgesics are a category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that are commonly used to relieve pain. They are designed to alleviate discomfort by targeting the body's pain receptors or by reducing inflammation. Analgesics are widely utilized in the medical field to manage various types of pain, ranging from mild to severe.
One of the primary classes of analgesics is nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by inhibiting the production of prostaglandins, substances that contribute to pain and inflammation. This class includes well-known drugs like ibuprofen and naproxen. Another class of analgesics is opioids, which are derived from opium or synthetic compounds that mimic the effects of opium. Opioids act on the central nervous system to reduce pain perception and provide potent pain relief. Examples of opioids include morphine, codeine, and oxycodone.
Analgesics are available in various forms, such as tablets, capsules, creams, and injections, allowing for different routes of administration based on the patient's needs. They are commonly used to manage pain associated with conditions like arthritis, headaches, dental procedures, and post-operative recovery.
It is important to note that analgesics should be used under medical supervision, as improper use or overuse can lead to adverse effects, including gastrointestinal complications, addiction, and respiratory depression in the case of opioids. Therefore, it is crucial for healthcare professionals to assess each patient's individual needs and prescribe the appropriate analgesic and dosage.
In summary, analgesics are a vital category of pharmaceutical APIs used to alleviate pain by targeting pain receptors or reducing inflammation. With various classes and forms available, they provide valuable options for pain management when used responsibly and under medical guidance.
