Cetalkonium API Manufacturers

General Description:

Cetalkonium, identified by CAS number 10328-34-4, is a notable compound with significant therapeutic applications. Cetalkonium is a C16 alkyl benzalkonium chloride derivative with an amphipathic property which allows it to be used in different types of formulations. It is a quaternary ammonium salt that acts as an antiseptic against a variety of bacteria and fungi. Cetalkonium is approved by the FDA for its use in over-the-counter products as a skin protectant. By Health Canada, it is also approved for its use in over-the-counter products.

Indications:

This drug is primarily indicated for: Cetalkonium is used as a surfactant, germicide, fungicide, mildew preventive agents in silicone-based water repellents, emulsifier, disinfectant, topical anti-infective, and antiseptic antimicrobial for pharmaceuticals. For its chemical properties and its antiseptical characteristics, cetalkonium can be used in a wide variety of products as part of the formulations and it is also determined to be an active antiseptic ingredient in over-the-counter preparations. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Cetalkonium undergoes metabolic processing primarily in: As cetalkonium is not absorbed, this pharmacokinetic property is not relevant. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Cetalkonium are crucial for its therapeutic efficacy: Cetalkonium is used mainly topically and it is not absorbed. When administered orally and parenterally, cetalkonium absorption may happen but it is very insignificant. The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Cetalkonium is an important consideration for its dosing schedule: As cetalkonium is not absorbed, this pharmacokinetic property is not relevant. This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Cetalkonium exhibits a strong affinity for binding with plasma proteins: As cetalkonium is not absorbed, this pharmacokinetic property is not relevant. This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Cetalkonium from the body primarily occurs through: As cetalkonium is not absorbed, this pharmacokinetic property is not relevant. When administered orally, most of the administered dose is excreted unchanged in the feces as it is very poorly absorbed. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Cetalkonium is distributed throughout the body with a volume of distribution of: As cetalkonium is not absorbed, this pharmacokinetic property is not relevant. This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Cetalkonium is a critical factor in determining its safe and effective dosage: As cetalkonium is not absorbed, this pharmacokinetic property is not relevant. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Cetalkonium exerts its therapeutic effects through: Cetalkonium is an antimicrobial agent and it has shown to be effective against both gram-positive, gram-negative bacteria and fungi. From this property, it has been shown to present a better activity against the gram-negative organisms. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Cetalkonium functions by: The activity of cetalkonium is based on the creation of a positive charge which permits a bio-adhesive property to negative surfaces. This property allows cetalkonium to disrupt the cell membrane, inactivate enzymes and denature proteins. This type of mechanism allows this type of agents to present a broad spectrum. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Classification:

Cetalkonium belongs to the class of organic compounds known as phenylmethylamines. These are compounds containing a phenylmethtylamine moiety, which consists of a phenyl group substituted by an methanamine, classified under the direct parent group Phenylmethylamines. This compound is a part of the Organic compounds, falling under the Benzenoids superclass, and categorized within the Benzene and substituted derivatives class, specifically within the Phenylmethylamines subclass.

Categories:

Cetalkonium is categorized under the following therapeutic classes: Alcohols, Amines, Ammonium Compounds, Anti-Infective Agents, Anti-Infective Agents, Local, Compounds used in a research, industrial, or household setting, Lipids, Nitrogen Compounds, Onium Compounds, Surface-Active Agents. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.

Experimental Properties:

Further physical and chemical characteristics of Cetalkonium include:

• Water Solubility: 8.5 g/L
• Melting Point: 54-58 ºC
• logP: 2.5