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Dehydroascorbic acid
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Looking for Dehydroascorbic acid API 490-83-5?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Dehydroascorbic acid. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Dehydroascorbic acid
- Synonyms:
- dehydro-L-ascorbic acid , DHAA , L-dehydroascorbate , L-dehydroascorbic acid , L-threo-2,3-hexodiulosonic acid, γ-lactone , L-threo-hexo-2,3-diulosono-1,4-lactone , Oxidized ascorbic acid , Oxidized vitamin C
- Cas Number:
- 490-83-5
- DrugBank number:
- DB08830
- Unique Ingredient Identifier:
- Y2Z3ZTP9UM
General Description:
Dehydroascorbic acid, identified by CAS number 490-83-5, is a notable compound with significant therapeutic applications. Dehydroascorbic acid is made from the oxidation of ascorbic acid. This reaction is reversible, but dehydroascorbic acid can instead undergo irreversible hydrolysis to 2,3-diketogulonic acid. Dehydroascorbic acid as well as ascorbic acid are both termed Vitamin C, but the latter is the main form found in humans. In the body, both dehydroascorbic acid and ascorbic acid have similar biological activity as antivirals but dehydroascorbic acid also has neuroprotective effects. Currently dehydroascorbic acid is an experimental drug with no known approved indications.
Indications:
This drug is primarily indicated for: There is no approved indication for dehydroascorbic acid, but it has potential therapeutic use in patients with certain viruses and ischemic stroke. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Pharmacodynamics:
Dehydroascorbic acid exerts its therapeutic effects through: Dehydroascorbic acid has similar biological activity as ascorbic acid. Both compounds have been shown to have antiviral effects against herpes simplex virus type 1, influenza virus type A and poliovirus type 1 with dehydroascorbic acid having the stronger effect. In addition, unlike ascorbic acid, dehydroascorbic acid can cross the blood brain barrier and is then converted to ascorbic acid to enable retention in the brain. This is important because one study has found that after an ischemic stroke, dehydroascorbic acid has neuroprotective effects by reducing infarct volume, neurological deficits, and mortality. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Dehydroascorbic acid functions by: Even though dehydroascorbic acid and ascorbic acid have similar effects, their mechanism of action seems to be different. The exact mechanism of action is still being investigated, but some have been elucidated. Concerning dehydroascorbic acid's antiviral effect against herpes simplex virus type 1, it is suggested that dehydroascorbic acid acts after replication of viral DNA and prevents the assembly of progeny virus particles. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Dehydroascorbic acid belongs to the class of organic compounds known as gamma butyrolactones. These are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom, classified under the direct parent group Gamma butyrolactones. This compound is a part of the Organic compounds, falling under the Organoheterocyclic compounds superclass, and categorized within the Lactones class, specifically within the Gamma butyrolactones subclass.
Categories:
Dehydroascorbic acid is categorized under the following therapeutic classes: Acids, Acyclic, Carbohydrates, Diet, Food, and Nutrition, Food, Hydroxy Acids, Lactones, Micronutrients, Physiological Phenomena, Sugar Acids, Urinary Acidifying Agents, Vitamin C and analogues, Vitamins. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Dehydroascorbic acid include:
- Water Solubility: Soluble in water at 60°C
- Melting Point: Decomposes at 225°C (437°F)
- pKa: 3.90
Dehydroascorbic acid is a type of Anti-infective Agents
Anti-infective agents are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used in the treatment of various infectious diseases. These agents play a crucial role in combating bacterial, viral, fungal, and parasitic infections. The demand for effective anti-infective APIs has grown significantly due to the increasing prevalence of drug-resistant microorganisms.
Anti-infective APIs encompass a wide range of substances, including antibiotics, antivirals, antifungals, and antiparasitics. Antibiotics are particularly important in fighting bacterial infections and are further categorized into different classes based on their mode of action and target bacteria. Antivirals are designed to inhibit viral replication and are essential in the treatment of viral infections such as influenza and HIV. Antifungals combat fungal infections, while antiparasitics are used to eliminate parasites that cause diseases like malaria and helminthiasis.
The development and production of high-quality anti-infective APIs require stringent manufacturing processes and adherence to regulatory standards. Pharmaceutical companies invest heavily in research and development to discover new and more effective anti-infective agents. Additionally, ensuring the safety, efficacy, and stability of these APIs is of utmost importance.
The global market for anti-infective APIs is driven by factors such as the rising incidence of infectious diseases, the emergence of new and drug-resistant pathogens, and the growing demand for improved healthcare infrastructure. Continuous advancements in pharmaceutical technology and the development of innovative drug delivery systems further contribute to the expansion of this market.
In conclusion, anti-infective agents are a critical category of pharmaceutical APIs that play a pivotal role in treating infectious diseases. Their effectiveness in combating various types of infections makes them essential components in the arsenal of modern medicine.
