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Ferric sulfate API Manufacturers & Suppliers

General Description:

Ferric sulfate, identified by CAS number 10028-22-5, is a notable compound with significant therapeutic applications. Ferric sulfate has the molecular formula of Fe2SO4, and it is a dark brown or yellow chemical agent with acidic properties. It is produced by the reaction of sulfuric acid and an oxidizing agent. It is used in different fields such as dermatology, dentistry and it is thought to present hemostatic properties by interacting chemically with blood proteins. By the FDA, ferric sulfate is a direct food substance affirmed in the GRAS category (Generally Recognized As Safe).

Indications:

This drug is primarily indicated for: Ferric sulfate was first used in dermatology as part of the Monsel's solution. This solution is an antihemorrhagic agent used in skin and mucosal biopsies. The use of ferric sulfate in dermatology is under review as ferric sulfate is corrosive and injurious and it can cause degenerative changes that are not observed with other alternatives like collagen. Ferric sulfate is also used as a coagulative and hemostatic agent. It is a mechanic hemostatic agent used directly on the damaged tissue. In dentistry, ferric sulfate is used as a pulpotomy medicament to control pulpal bleeding, as an antibacterial agent and as a hemostatic reagent for restorative dentistry, for postextraction hemorrhage and for periradicular and endodontic surgery. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Ferric sulfate undergoes metabolic processing primarily in: Pharmacokinetic studies related to the metabolism of ferric sulfate have not been performed. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Ferric sulfate are crucial for its therapeutic efficacy: Pharmacokinetic studies related to the absorption of ferric sulfate have not been performed. The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Ferric sulfate is an important consideration for its dosing schedule: Pharmacokinetic studies related to the half-life of ferric sulfate have not been performed. This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Ferric sulfate exhibits a strong affinity for binding with plasma proteins: Ferric sulfate presents very high protein binding properties, this property is thought to be due to its acidic profile. This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Ferric sulfate from the body primarily occurs through: Pharmacokinetic studies related to the elimination of ferric sulfate have not been performed. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Ferric sulfate is distributed throughout the body with a volume of distribution of: Pharmacokinetic studies related to the volume of distribution of ferric sulfate have not been performed. This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Ferric sulfate is a critical factor in determining its safe and effective dosage: Pharmacokinetic studies related to the clearance of ferric sulfate have not been performed. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Ferric sulfate exerts its therapeutic effects through: The administration of ferric sulfate as a dermatologic agent has showed delayed reepithelialization and dyspigmentation. Some studies have reported the generation of inflammation in the sites of administration of ferric sulfate. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Ferric sulfate functions by: The main function of ferric sulfate is as a hemostatic agent in different medical practices. This hemostatic function is achieved when ferric sulfate is applied directly in the damaged tissue. Once applied, ferric sulfate forms ferric ion-protein complex which helps the sealing of the damaged vessels mechanically. The formation of agglutinated protein complexes produces the generation of occlusion in the capillary orifices. The formation of the ferric protein complex is thought to be due to a chemical reaction between the acidic form of ferric sulfate and the blood proteins. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Classification:

Ferric sulfate belongs to the class of inorganic compounds known as transition metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is a transition metal, classified under the direct parent group Transition metal sulfates. This compound is a part of the Inorganic compounds, falling under the Mixed metal/non-metal compounds superclass, and categorized within the Transition metal oxoanionic compounds class, specifically within the Transition metal sulfates subclass.

Categories:

Ferric sulfate is categorized under the following therapeutic classes: Hematinics, Iron Compounds. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.

Experimental Properties:

Further physical and chemical characteristics of Ferric sulfate include:

• Water Solubility: Soluble at room temperature
• Melting Point: The Anhydrous form decomposes (480ºC)
• Boiling Point: The Anhydrous form decomposes (480ºC)