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Corticosterone
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Looking for Corticosterone API 50-22-6?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Corticosterone. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Corticosterone
- Synonyms:
- (11β)-11,21-dihydroxypregn-4-ene-3,20-dione , 11beta,21-Dihydroxy-4-pregnene-3,20-dione , 11β,21-dihydroxyprogesterone , 17-deoxycortisol , Kendall's compound B , Reichstein's substance H
- Cas Number:
- 50-22-6
- DrugBank number:
- DB04652
- Unique Ingredient Identifier:
- W980KJ009P
General Description:
Corticosterone, identified by CAS number 50-22-6, is a notable compound with significant therapeutic applications. An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
Classification:
Corticosterone belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone, classified under the direct parent group 21-hydroxysteroids. This compound is a part of the Organic compounds, falling under the Lipids and lipid-like molecules superclass, and categorized within the Steroids and steroid derivatives class, specifically within the Hydroxysteroids subclass.
Categories:
Corticosterone is categorized under the following therapeutic classes: 11-Hydroxycorticosteroids, Adrenal Cortex Hormones, Anti-Inflammatory Agents, Cytochrome P-450 CYP3A Substrates, Cytochrome P-450 CYP3A4 Substrates, Cytochrome P-450 Substrates, Fused-Ring Compounds, Hormones, Hormones, Hormone Substitutes, and Hormone Antagonists, Hydroxycorticosteroids, Pregnanes, Pregnenediones, Pregnenes, Steroids. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Corticosterone is a type of Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
