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Cortisone
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Looking for Cortisone API 53-06-5?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Cortisone. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Cortisone
- Synonyms:
- 11-dehydro-17-hydroxycorticosterone , 17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione , 17α,21-dihydroxy-4-pregnene-3,11,20-trione , 4-pregnene-17α,21-diol-3,11,20-trione , Cortisona , Cortisonum , Kendall's compound E , Kortison , pregn-4-en-17α,21-diol-3,11,20-trione , Reichstein's substance Fa , Wintersteiner's compound F
- Cas Number:
- 53-06-5
- DrugBank number:
- DB14681
- Unique Ingredient Identifier:
- V27W9254FZ
General Description:
Cortisone, identified by CAS number 53-06-5, is a notable compound with significant therapeutic applications. A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite hydrocortisone. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
Categories:
Cortisone is categorized under the following therapeutic classes: 17-Hydroxycorticosteroids, Adrenal Cortex Hormones, Anti-Inflammatory Agents, Corticosteroid Hormone Receptor Agonists, Corticosteroids, Corticosteroids for Systemic Use, Corticosteroids for Systemic Use, Plain, Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 Inducers, Cytochrome P-450 CYP3A4 Inducers (strength unknown), Cytochrome P-450 CYP3A5 Inducers, Cytochrome P-450 CYP3A5 Inducers (strength unknown), Cytochrome P-450 Enzyme Inducers, Fused-Ring Compounds, Glucocorticoids, Hormones, Hormones, Hormone Substitutes, and Hormone Antagonists, Hydroxycorticosteroids, Ophthalmologicals, Pregnanes, Pregnenes, Sensory Organs, Steroids, Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Cortisone is a type of Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
