Diethylamino hydroxybenzoyl hexyl benzoate API Manufacturers

General Description:

Diethylamino hydroxybenzoyl hexyl benzoate, identified by CAS number 302776-68-7, is a notable compound with significant therapeutic applications. Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions . Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe in 2005, and is also marketed in the U.S, South America, Mexico, Japan and Taiwan. It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability . It is used in concentrations up to 10% in sunscreen products, either alone or in combination with other UV absorbers .

Indications:

This drug is primarily indicated for: Indicated for use as a sunscreen agent. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Diethylamino hydroxybenzoyl hexyl benzoate undergoes metabolic processing primarily in: In steady-state and transient photolysis experiments _in vitro_, diethylamino hydroxybenzoyl hexyl benzoate may be oxidized by H2O2/UV to form degradation products . Like other UV filters, diethylamino hydroxybenzoyl hexyl benzoate may be subject to photodegradation upon absorption of UV radiation, which results in the compound passing from a ground state to either a singlet or triplet excited state . This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Diethylamino hydroxybenzoyl hexyl benzoate are crucial for its therapeutic efficacy: Based on the findings of a rat study assessing dermal or percutaneous absorption, only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most of the compounds will remain in the upper layers of the stratum corneum . In rat and porcine skin, the percutaneous absorption was 0.10 ± 0.12 μg/cm^2 or 0.04 ± 0.05% . The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Diethylamino hydroxybenzoyl hexyl benzoate is an important consideration for its dosing schedule: No pharmacokinetic data. This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Diethylamino hydroxybenzoyl hexyl benzoate exhibits a strong affinity for binding with plasma proteins: No pharmacokinetic data. This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Diethylamino hydroxybenzoyl hexyl benzoate from the body primarily occurs through: No pharmacokinetic data. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Diethylamino hydroxybenzoyl hexyl benzoate is distributed throughout the body with a volume of distribution of: No pharmacokinetic data. This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Diethylamino hydroxybenzoyl hexyl benzoate is a critical factor in determining its safe and effective dosage: No pharmacokinetic data. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Diethylamino hydroxybenzoyl hexyl benzoate exerts its therapeutic effects through: Diethylamino hydroxybenzoyl hexyl benzoate is an organic UV filter that attenuates the exposure of UV radiation on human skin . _In vitro_, topical application of diethylamino hydroxybenzoyl hexyl benzoate exerted an anti-inflammatory effect on inflammation-evoked mouse ears by inhibiting oedema formation . The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Diethylamino hydroxybenzoyl hexyl benzoate functions by: Diethylamino hydroxybenzoyl hexyl benzoate absorbs in the UV-A range with the peak at 354 nm . This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Classification:

Diethylamino hydroxybenzoyl hexyl benzoate belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups, classified under the direct parent group Benzophenones. This compound is a part of the Organic compounds, falling under the Benzenoids superclass, and categorized within the Benzene and substituted derivatives class, specifically within the Benzophenones subclass.

Categories:

Diethylamino hydroxybenzoyl hexyl benzoate is categorized under the following therapeutic classes: Amines, Aniline Compounds, Benzene Derivatives, Ketones, Phenols, Sunscreen Agents. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.

Experimental Properties:

Further physical and chemical characteristics of Diethylamino hydroxybenzoyl hexyl benzoate include:

• Water Solubility:< 0.01 mg/L
• Melting Point: 54, Decomposes at 314
• logP: 6.2