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Diethylamino hydroxybenzoyl hexyl benzoate
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Looking for Diethylamino hydroxybenzoyl hexyl benzoate API 302776-68-7?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Diethylamino hydroxybenzoyl hexyl benzoate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Diethylamino hydroxybenzoyl hexyl benzoate
- Synonyms:
- Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate
- Cas Number:
- 302776-68-7
- DrugBank number:
- DB11269
- Unique Ingredient Identifier:
- ANQ870JD20
General Description:
Diethylamino hydroxybenzoyl hexyl benzoate, identified by CAS number 302776-68-7, is a notable compound with significant therapeutic applications. Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions . Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe in 2005, and is also marketed in the U.S, South America, Mexico, Japan and Taiwan. It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability . It is used in concentrations up to 10% in sunscreen products, either alone or in combination with other UV absorbers .
Indications:
This drug is primarily indicated for: Indicated for use as a sunscreen agent. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Diethylamino hydroxybenzoyl hexyl benzoate undergoes metabolic processing primarily in: In steady-state and transient photolysis experiments _in vitro_, diethylamino hydroxybenzoyl hexyl benzoate may be oxidized by H2O2/UV to form degradation products . Like other UV filters, diethylamino hydroxybenzoyl hexyl benzoate may be subject to photodegradation upon absorption of UV radiation, which results in the compound passing from a ground state to either a singlet or triplet excited state . This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Diethylamino hydroxybenzoyl hexyl benzoate are crucial for its therapeutic efficacy: Based on the findings of a rat study assessing dermal or percutaneous absorption, only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most of the compounds will remain in the upper layers of the stratum corneum . In rat and porcine skin, the percutaneous absorption was 0.10 ± 0.12 μg/cm^2 or 0.04 ± 0.05% . The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Diethylamino hydroxybenzoyl hexyl benzoate is an important consideration for its dosing schedule: No pharmacokinetic data. This determines the duration of action and helps in formulating effective dosing regimens.
Protein Binding:
Diethylamino hydroxybenzoyl hexyl benzoate exhibits a strong affinity for binding with plasma proteins: No pharmacokinetic data. This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Route of Elimination:
The elimination of Diethylamino hydroxybenzoyl hexyl benzoate from the body primarily occurs through: No pharmacokinetic data. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Diethylamino hydroxybenzoyl hexyl benzoate is distributed throughout the body with a volume of distribution of: No pharmacokinetic data. This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Diethylamino hydroxybenzoyl hexyl benzoate is a critical factor in determining its safe and effective dosage: No pharmacokinetic data. It reflects the efficiency with which the drug is removed from the systemic circulation.
Pharmacodynamics:
Diethylamino hydroxybenzoyl hexyl benzoate exerts its therapeutic effects through: Diethylamino hydroxybenzoyl hexyl benzoate is an organic UV filter that attenuates the exposure of UV radiation on human skin . _In vitro_, topical application of diethylamino hydroxybenzoyl hexyl benzoate exerted an anti-inflammatory effect on inflammation-evoked mouse ears by inhibiting oedema formation . The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Diethylamino hydroxybenzoyl hexyl benzoate functions by: Diethylamino hydroxybenzoyl hexyl benzoate absorbs in the UV-A range with the peak at 354 nm . This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Classification:
Diethylamino hydroxybenzoyl hexyl benzoate belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups, classified under the direct parent group Benzophenones. This compound is a part of the Organic compounds, falling under the Benzenoids superclass, and categorized within the Benzene and substituted derivatives class, specifically within the Benzophenones subclass.
Categories:
Diethylamino hydroxybenzoyl hexyl benzoate is categorized under the following therapeutic classes: Amines, Aniline Compounds, Benzene Derivatives, Ketones, Phenols, Sunscreen Agents. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Diethylamino hydroxybenzoyl hexyl benzoate include:
- Water Solubility:< 0.01 mg/L
- Melting Point: 54, Decomposes at 314
- logP: 6.2
Diethylamino hydroxybenzoyl hexyl benzoate is a type of Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
