Ethyl pyruvate API Manufacturers
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Looking for Ethyl pyruvate API 617-35-6?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Ethyl pyruvate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Ethyl pyruvate
- Synonyms:
- 2-oxopropanoic acid ethyl ester , 2-oxopropionic acid ethyl ester , Ethyl 2-oxopropanoate , Ethyl 2-oxopropionate , Ethyl methylglyoxylate , Pyruvic acid ethyl ester , Pyruvic acid, ethyl ester
- Cas Number:
- 617-35-6
- DrugBank number:
- DB05869
- Unique Ingredient Identifier:
- 03O98E01OB
General Description:
Ethyl pyruvate, identified by CAS number 617-35-6, is a notable compound with significant therapeutic applications. CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory conditions. CTI-01 shows a potent anti-inflammatory and tissue protection activity in multiple animal models of disease including pancreatitis, ischemia-reperfusion injury, sepsis, renal injury and endotoxemia.
Indications:
This drug is primarily indicated for: Investigated for use/treatment in burns and burn infections, cardiac surgery, inflammatory disorders (unspecified), ischemic reperfusion injury, and sepsis and septicemia. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Mechanism of Action:
Ethyl pyruvate functions by: CTI-01 inhibits the systemic release of cytokines, such as TNF-alpha and HMGB1, which promote the body's inflammatory response. The over-expression of these cytokines has been linked to diseases that occur in critical care settings, such as severe organ damage following cardiopulmonary bypass (CPB) and post-operative ileus following abdominal surgery. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Ethyl pyruvate belongs to the class of organic compounds known as alpha-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon, classified under the direct parent group Alpha-keto acids and derivatives. This compound is a part of the Organic compounds, falling under the Organic acids and derivatives superclass, and categorized within the Keto acids and derivatives class, specifically within the Alpha-keto acids and derivatives subclass.
Categories:
Ethyl pyruvate is categorized under the following therapeutic classes: Keto Acids. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Ethyl pyruvate is a type of Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
