Geraniol API Manufacturers
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Looking for Geraniol API 106-24-1?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Geraniol. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Geraniol
- Synonyms:
- (2E)-3,7-dimethylocta-2,6-dien-1-ol , (E)-3,7-Dimethyl-2,6-octadien-1-ol , (E)-(E)-Nerol , 2-trans-3,7-Dimethyl-2,6-octadien-1-ol , 2,6-Octadien-1-ol, 3,7-dimethyl-, (E)- , 2,6-Octadien-1-ol, 3,7-dimethyl-, trans- , 3,7-Dimethyl-2,6-octadien-1-ol, (E)- , 3,7-Dimethyl-trans-2,6-octadien-1-ol , geranyl alcohol , Lemonol , t-geraniol
- Cas Number:
- 106-24-1
- DrugBank number:
- DB14183
- Unique Ingredient Identifier:
- L837108USY
General Description:
Geraniol, identified by CAS number 106-24-1, is a notable compound with significant therapeutic applications. Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from the flowers of many species of plant and is commonly used by the food, fragrance, and cosmetic industry. Geraniol has demonstrated a wide spectrum of pharmacological activities including antimicrobial, anti-inflammatory, antioxidant, anti-cancer, and neuroprotective to name a few . Interestingly, geraniol has also been shown to sensitize tumour cells to commonly used chemotherapies including and and represents a promising cancer chemopreventive agent . Due to its anticancer effects, geraniol has been found to be effective against a broad range of cancers including breast, lung, colon, prostate, pancreatic, skin, liver, kidney and oral cancers . These pharmacologic effects are clinically important as geraniol is classified as generally-recognized-as-safe (GRAS) by the Flavor and Extract Manufacturers Association (FEMA) and the Food and Drug Administration (FDA) of the United States. Sensitivity to geraniol may be identified with a clinical patch test.
Indications:
This drug is primarily indicated for: Geraniol is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Absorption:
The absorption characteristics of Geraniol are crucial for its therapeutic efficacy: The profile of the geraniol concentrations in rat blood following oral administration of the emulsified formulation was characterized by a peak concentration at 30 min of about 270 μg/mL and an area under concentration (AUC) similar to that obtained by the intravenous administration of the same geraniol dose, indicating an absolute bioavailability of 92% . Geraniol appears able to permeate directly from the bloodstream to the central nervous system following its oral administration to rats, reaching detectable amounts in the CSF; peak concentration in the CSF was found to be about 2.5 μg/mL and was observed 30 min after oral administration . The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Geraniol is an important consideration for its dosing schedule: In vitro measurements indicated that geraniol is highly stable in human and rat whole blood, whereas following intravenous administration geraniol is eliminated from the bloodstream with a relatively short half-life (about 12 min), starting from a concentration of about 300 μg/mL . This determines the duration of action and helps in formulating effective dosing regimens.
Categories:
Geraniol is categorized under the following therapeutic classes: Cell-mediated Immunity, Increased Histamine Release, Monoterpenes, Standardized Chemical Allergen, Terpenes. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Geraniol is a type of Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
