Levomenol API Manufacturers
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Looking for Levomenol API 23089-26-1?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Levomenol. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Levomenol
- Synonyms:
- (-)-alpha-Bisabolol , alpha-(-)-bisabolol , alpha-bisabolol , Bisabolol , Kamillosan , α-(−)-bisabolol
- Cas Number:
- 23089-26-1
- DrugBank number:
- DB13153
- Unique Ingredient Identifier:
- 24WE03BX2T
General Description:
Levomenol, identified by CAS number 23089-26-1, is a notable compound with significant therapeutic applications. Bisabolol, or more formally α-(−)-bisabolol or also known as levomenol, (-)-alpha-Bisabolol is found in fats and oils. (-)-alpha-Bisabolol is isolated from essential oil of Matricaria chamomilla (German chamomile) (-)-alpha-Bisabolol belongs to the family of Sesquiterpenes. These are terpenes with three consecutive isoprene units.
Indications:
This drug is primarily indicated for: Levomenol has been known to elicit a number of potentially beneficial pharmacological effects, including anti-irritant, anti-inflammatory, and anti-microbial actions. Bisabolol is also demonstrated to enhance the percutaneous absorption of certain molecules. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Absorption:
The absorption characteristics of Levomenol are crucial for its therapeutic efficacy: The purpose of the present investigations was to study the cutaneous absorption of sesquiterpenic alcohol, the major active principle of chamomile. For these investigations 14C-labelled levomenol ((-)-6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; (-)-alpha-bisabolol) was prepared by biochemical incorporation of -acetate into the molecule. 5 h after topical application of the radiolabelled substance onto nude mice half of the radioactivity was found in the skin. The other part was measured in tissue and organes. 90% of this radioactivity was analysed as intact levomenol. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Volume of Distribution:
Levomenol is distributed throughout the body with a volume of distribution of: To demonstrate the distribution of the substance in the skin a part of this tissue was cutted into horizontal slices by a cryotome. From the slices autoradiograms were produced. The densitometric measuration showed that there was a fast penetration of levomenol into the skin. 5 h after the topical application the substance was displaced from outermost to innermost areas. From these results a fast cutaneous absorption and a long therapeutical effect of the antiphlogistic and spasmolytic levomenol in the skin can be expected. This metric indicates how extensively the drug permeates into body tissues.
Pharmacodynamics:
Levomenol exerts its therapeutic effects through: Levomenol is an anti-inflammatory and natural moisturizing agent that has been found to diminish the signs of photodamage, reduce pruritus, and ameliorate skin texture and elasticity. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Classification:
Levomenol belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units, classified under the direct parent group Sesquiterpenoids. This compound is a part of the Organic compounds, falling under the Lipids and lipid-like molecules superclass, and categorized within the Prenol lipids class, specifically within the Sesquiterpenoids subclass.
Categories:
Levomenol is categorized under the following therapeutic classes: Biological Products, Complex Mixtures, Lipids, OATP1B1/SLCO1B1 Substrates, OATP1B3 substrates, Oils, Pharmaceutical Preparations, Plant Preparations, Sesquiterpenes, Terpenes. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Levomenol is a type of Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
