Bezlotoxumab API Manufacturers

General Description:

Bezlotoxumab, identified by CAS number 1246264-45-8, is a notable compound with significant therapeutic applications. Bezlotoxumab is a human monoclonal antibody that binds to Clostridium difficile toxin B and neutralizes its effects. Used to reduce the recurrence of Clostridium difficle infection in adults receiving antibiotic therapy to treat C. difficile infection and high risk of recurrence.

Indications:

This drug is primarily indicated for: Prevents recurrence of Clostridium difficile infection in people 18 years or older who are either currently receiving treatment for C. difficile infection or have a high risk of recurrence. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Bezlotoxumab undergoes metabolic processing primarily in: Catabolism. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Bezlotoxumab are crucial for its therapeutic efficacy: Not absorbed since give IV. The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Bezlotoxumab is an important consideration for its dosing schedule: 19 Days. This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Bezlotoxumab exhibits a strong affinity for binding with plasma proteins: Binds to C.difficile virulence factor toxin B which prevents its action on host cells. This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Bezlotoxumab from the body primarily occurs through: Catabolism. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Bezlotoxumab is distributed throughout the body with a volume of distribution of: 7.33L. This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Bezlotoxumab is a critical factor in determining its safe and effective dosage: 0.317 L/day. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Bezlotoxumab exerts its therapeutic effects through: Bezlotoxumab binds to C.difficile toxin B, a virulence factor common to practically all C.difficile, which prevents the bacteria from infecting host cells. Bezlotoxumab binds two epitopes of toxin B, via two Fab regions, which partially blocks the carbohydrate binding pockets of the toxin resulting in the prevention of toxin B from binding to host cells. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Bezlotoxumab functions by: A single molecule of bezlotoxumab neutralizes Toxin B by binding its two Fab regions to two epitopes within the N-terminal half of the Toxin B CROP domain, partially blocking the carbohydrate binding pockets of the toxin and preventing toxin binding to host cells. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Classification:

Bezlotoxumab belongs to the None, classified under the direct parent group Peptides. This compound is a part of the Organic Compounds, falling under the Organic Acids superclass, and categorized within the Carboxylic Acids and Derivatives class, specifically within the Amino Acids, Peptides, and Analogues subclass.

Categories:

Bezlotoxumab is categorized under the following therapeutic classes: Amino Acids, Peptides, and Proteins, Antibacterial monoclonal antibodies, Antibodies, Antibodies, Monoclonal, Antibodies, Neutralizing, Antiinfectives for Systemic Use, Blood Proteins, Globulins, Immune Sera and Immunoglobulins, Immunoglobulins, Immunoproteins, Proteins, Serum Globulins, Specific Immunoglobulins. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.