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Pectin
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Looking for Pectin API 9000-69-5?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Pectin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Pectin
- Synonyms:
- Cas Number:
- 9000-69-5
- DrugBank number:
- DB11158
- Unique Ingredient Identifier:
- 89NA02M4RX
General Description:
Pectin, identified by CAS number 9000-69-5, is a notable compound with significant therapeutic applications. Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts or as acid amides. Under the FDA regulation, pectin qualifies as a GRAS (generally recognized as safe) food substance. This status allows pectin to be used with no limitations.
Indications:
This drug is primarily indicated for: Pectin is used in food as a gelling agent and stabilizer. As a medical drug, it has obtained a great interest in its potential use as a source of dietary fiber, lipid, cholesterol, serum glucose and insulin level lowering effect, gastric emptying delay. Some recent studies have researched the possibility of using pectin for the formation of nanoparticles as a delivery vehicle of drugs. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Pectin undergoes metabolic processing primarily in: Pectin is depolymerized and de-esterified to a very small extent. It passes to the small intestine as a macromolecule and the majority of the pectin is eliminated unchanged. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Pectin are crucial for its therapeutic efficacy: Pectin is not absorbed and it is not distributed in the body. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Pectin is an important consideration for its dosing schedule: Pharmacokinetic studies have not been performed as pectin is not absorbed. This determines the duration of action and helps in formulating effective dosing regimens.
Protein Binding:
Pectin exhibits a strong affinity for binding with plasma proteins: Pharmacokinetic studies have not been performed as pectin is not absorbed. This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Route of Elimination:
The elimination of Pectin from the body primarily occurs through: Pectin is completely excreted in the feces, including a small amount of trigalacturonic acid that can be found in the colon. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Pectin is distributed throughout the body with a volume of distribution of: Pharmacokinetic studies have not been performed as pectin is not absorbed. This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Pectin is a critical factor in determining its safe and effective dosage: Pharmacokinetic studies have not been performed as pectin is not absorbed. It reflects the efficiency with which the drug is removed from the systemic circulation.
Pharmacodynamics:
Pectin exerts its therapeutic effects through: Pectin increases viscosity and volume of stools which helps it to be used for constipation and diarrhea. It is reported as well to present lowering effects of different body components. This effect depends on the type of pectin which indicated that this effect is related to the composition of the correspondent pectin. Nonetheless, this data is still unclear and more studies need to be performed to conclude this effect of pectin. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Pectin functions by: Pectin is an adsorbent that binds to bacteria, toxins and other irritants in the intestinal mucosa. Pectin is able to decrease the pH in the intestinal lumen and provides a soothing effect on the irritated mucosa. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Categories:
Pectin is categorized under the following therapeutic classes: Alimentary Tract and Metabolism, Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents, Biological Products, Biopolymers, Carbohydrates, Complex Mixtures, Compounds used in a research, industrial, or household setting, Diet, Food, and Nutrition, Food, Food Additives, Food Ingredients, Intestinal Adsorbents, Macromolecular Substances, Physiological Phenomena, Plant Extracts, Plant Preparations, Polymers, Polysaccharides. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Pectin include:
- Water Solubility: Partially soluble in cold water
- Melting Point: 6.1ºC
- Boiling Point: 415.5ºC at 760 mmHg
Pectin is a type of Antidiarrheals
Antidiarrheals are a category of pharmaceutical active pharmaceutical ingredients (APIs) that are commonly used to treat diarrhea. Diarrhea is a common gastrointestinal disorder characterized by frequent loose or watery stools. It can be caused by various factors, including viral or bacterial infections, food poisoning, medication side effects, or digestive disorders.
Antidiarrheals work by targeting the underlying causes of diarrhea to alleviate symptoms and restore normal bowel function. These APIs can be classified into several subcategories, including opioids, antimotility agents, and adsorbents.
Opioid-based antidiarrheals, such as loperamide, function by slowing down intestinal motility and reducing excessive bowel contractions. By doing so, they help to decrease the frequency and urgency of bowel movements.
Antimotility agents, such as diphenoxylate with atropine, act on the intestinal muscles to inhibit peristalsis, the wave-like movements that propel stool through the intestines. This helps to slow down the passage of stools and allows for more efficient absorption of fluids and electrolytes.
Adsorbent antidiarrheals, like activated charcoal, function by binding to toxins and bacteria in the digestive tract, preventing their absorption and facilitating their elimination from the body.
Overall, antidiarrheals are valuable pharmaceutical APIs that provide relief from diarrhea by addressing its underlying causes. It is important to note that these medications should be used under the guidance of healthcare professionals, as the appropriate choice of antidiarrheal and dosage may vary depending on the specific condition and patient characteristics.
